Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial

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dc.authorid0000-0002-5286-4981
dc.authorid0000-0002-2306-5937
dc.authorid0000-0001-5118-4776
dc.authorid0000-0001-7566-1063
dc.authorid0000-0003-4292-5717
dc.contributor.authorHajebrahimi, Farzin
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2022-06-16T06:53:21Z
dc.date.available2022-06-16T06:53:21Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoterapi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractThere are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients with Parkinson's Disease (PD). The purpose of this study was to investigate the synergistic therapeutic effects of Virtual Reality based EG on motor and cognitive symptoms in PD and its possible effects on neuroplasticity. Eligible patients with the diagnosis of PD were randomly assigned to one of the two study groups: (1) an experimental EG group, (2) an active control Exercise Therapy (ET) group. All patients participated in a 4-week exercise program consisting of 12 treatment sessions. Every session lasted 60 min. Participants underwent a motor evaluation, extensive neuropsychological assessment battery and rs-fMRI before and after the interventions. Thirty patients fulfilled the inclusion criteria and were randomly assigned to the EG and ET groups. After the dropouts, 23 patients completed the assessments and interventions (11 in EG, 13 in ET). Within group analysis showed significant improvements in both groups. Between group comparisons considering the interaction of group x time effect, showed superiority of EG in terms of general cognition, delayed visual recall memory and Boston Naming Test. These results were consistent in the within-group and between-group analysis. Finally, rs-fMRI analysis showed increased activity in the precuneus region in the time x group interaction in the favor of EG group. EG can be an effective alternative in terms of motor and cognitive outcomes in patients with PD. Compared to ET, EG may affect brain functional connectivity and can have beneficial effects on patients' cognitive functions and motor symptoms. Whenever possible, using EG and ET in combination, may have the better effects on patients daily living and patients can benefit from the advantages of both interventions.
dc.identifier.citationHajebrahimi, F., Velioğlu, H. A., Bayraktaroğlu, Z., Helvacı Yılmaz, N. ve Hanoğlu, L. (2022). Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-12061-3
dc.identifier.doi10.1038/s41598-022-12061-3
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid35577874
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-022-12061-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9522
dc.identifier.volume12
dc.identifier.wos000796701700002en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHajebrahimi, Farzin
dc.institutionauthorVelioglu, Halil Aziz
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.institutionauthorHelvacı Yılmaz, Nesrin
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectfMRI Analysis
dc.subjectParkinson's Disease
dc.subjectControlled Trial
dc.titleClinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial
dc.typeArticle

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