Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?

Günal, Mehmet Yalçın; Şahinler Ayla, Sibel; Çaglayan, Berrak; Beker, Mustafa Çağlar; Bedri, Nejda; Aslan, İpek Bilge; Özdemir, Ekrem Musa; Kılıç, Ertuğrul; Yeşilada, Elif

Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?

dc.authorid	0000-0001-7702-2441
dc.authorid	0000-0002-1332-1968
dc.authorid	0000-0002-5072-132X
dc.authorid	0000-0002-9476-8488
dc.authorid	0000-0002-6029-1626
dc.authorid	0000-0001-9416-7757
dc.authorid	0000-0001-6494-8923
dc.contributor.author	Günal, Mehmet Yalçın
dc.contributor.author	Şahinler Ayla, Sibel
dc.contributor.author	Çaglayan, Berrak
dc.contributor.author	Beker, Mustafa Çağlar
dc.contributor.author	Bedri, Nejda
dc.contributor.author	Aslan, İpek Bilge
dc.contributor.author	Özdemir, Ekrem Musa
dc.contributor.author	Kılıç, Ertuğrul
dc.contributor.author	Yeşilada, Elif
dc.date.accessioned	2021-12-30T12:00:09Z
dc.date.available	2021-12-30T12:00:09Z
dc.date.issued	2021
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstract	OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, the damaged tissue undergoes a process of regenerating itself, which is called wound healing. METHODS: Centella asiatica extract (CAE) was used as the reference molecule in the study. The wound healing process was tested by using the excisional and incisional wound model. On the 12th day of the study, maximum stress, stress, % of elongation values were evaluated in the incisional wound. Also; histological parameters and macroscopic photographic analyses were evaluated in the excisional wound. RESULTS: In the photo evaluations, the improvement was more prominent in both CAE and CEPE groups than in the control group. Histological evaluation showed that CEPE group had signifi cant wound healing activity compared to the control and CAE groups. Axial tensile-elongation experiments in incisional wound tissue show that there was no signifi cant difference between CAE and CEPE groups. CONCLUSION: Liposomal formulations of C.edulis extract were found to have positive effects on the healing process, both on excisional and incisional wound tissues (Tab. 2, Fig. 3, Ref. 30).
dc.identifier.citation	Günal, M. Y., Şahinler Ayla, S., Çağlayan, B., Beker, M. Ç., Bedri, N., Aslan, İ. B. ... Yeşilada, E. (2021). Can Carpobrotus edulis, heal incisional and excisional wounds on the skin? Bratislava Medical Journal-Bratislavske Lekarske Listy, 122(12), 912-917. https://doi.org/10.4149/BLL_2021_147
dc.identifier.doi	10.4149/BLL_2021_147
dc.identifier.endpage	917
dc.identifier.issn	0006-9248
dc.identifier.issn	1336-0345
dc.identifier.issue	12
dc.identifier.scopusquality	Q3
dc.identifier.startpage	912
dc.identifier.uri	https://doi.org/10.4149/BLL_2021_147
dc.identifier.uri	https://hdl.handle.net/20.500.12511/8739
dc.identifier.volume	122
dc.identifier.wosquality	Q3
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Comenius University
dc.relation.ispartof	Bratislava Medical Journal-Bratislavske Lekarske Listy	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Carpobrotus Edulis
dc.subject	Liposome
dc.subject	Incisional Wound
dc.subject	Excisional Wound
dc.subject	Axial Tensile-Elongation Tests
dc.title	Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?
dc.type	Article