Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): An immunohistochemical study correlation with novel marker INSL-3

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dc.authorid0000-0002-4899-9146
dc.contributor.authorÇetin, Çağlar
dc.contributor.authorÖkten, Sabri Berkem
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorÖzcan, Pınar
dc.contributor.authorGökmen Karasu, Ayşe Filiz
dc.contributor.authorTanoğlu, Fatma Başak
dc.contributor.authorTaha, Havva Sevde
dc.contributor.authorAteş, Seda
dc.date.accessioned2024-01-23T10:29:43Z
dc.date.available2024-01-23T10:29:43Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy).Materials and Methods: Forty-two Sprague-Dawley rats were randomly allocated into seven distinct groups as; Group 1(control): NaCl intraperitoneal (IP) injection was administered on days D1, D7, and D14. Group 2(Cy):Cy IP injection on D1 + NaCl IP injection on D7 and D14 were administered. Group 3(PRP): PRP IP injection on D1,D7 and D14 were administered. Group 4(Cy + PRP):Cy IP injection on D1 and PRP IP injection on D1, D7 and D14 were administered. Group 5(G-CSF): G-CSF IP injection on D1, D7 and D14 were administered. Group 6(Cy + G-CSF):Cy IP injection on D1+ G-CSF IP injection on D1, D7 and D14 were administered. Group 7(Cy + PRP + G-CSF):Cy IP injection on D1+ PRP IP injection on D1,D7 and D14+ G-CSF IP injection on D1,D7 and D14 were administered. Follicular number, histological scores of AMH and INSL3 stained follicles at different stages of follicular development, and serum Anti-Mullerian hormone(AMH) were evaluated.Results: The primary, secondary, and antral follicle intensity scores for AMH-positive staining were most prominent in Groups 3 and 5. There was no significant difference between groups 4, 6 and 7 compared to group 1 in terms of follicule counts and AMH staining. The intensity scores of AMH-positive staining follicles were notably reduced in group 2 compared to groups 4, 6, and 7, with a significant difference (p < .01). Among the groups, group 2 exhibited the least intense antral follicle staining for INSL3, displaying a significant difference(p < .01) compared to the remaining groups.Conclusions: Autologous PRP and G-CSF might protect ovarian function in the face of ovarian damage caused by Cy-induced effects.
dc.description.sponsorshipBezmialem Scientific Research Committeeen_US
dc.identifier.citationÇetin, Ç., Ökten, S. B., Tok, O. E., Özcan, P., Gökmen Karasu, A. F., Tanoğlu, F. B. ... Ateş, S. (2024). Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): An immunohistochemical study correlation with novel marker INSL-3. Gynecological Endocrinology, 40(1). https://dx.doi.org/10.1080/09513590.2023.2301551
dc.identifier.doi10.1080/09513590.2023.2301551
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue1
dc.identifier.pmid38195404
dc.identifier.scopus2-s2.0-85181897266
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2023.2301551
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12188
dc.identifier.volume40
dc.identifier.wos001141560000001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTok, Olgu Enis
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectFollicle
dc.subjectG-csf
dc.subjectOvarian Failure
dc.subjectInSl3 Ovary
dc.subjectPlatelet-Rich Plasma
dc.titleTreatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): An immunohistochemical study correlation with novel marker INSL-3
dc.typeArticle

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