Important roles of interleukin-36, interleukin-37, and interleukin-38 cytokines in the pathogenesis of rosacea

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dc.authorid0000-0003-3560-849X
dc.contributor.authorEkinci, Alper
dc.contributor.authorOğuz Kılıç, Sevilay
dc.contributor.authorDemir, Nesrin
dc.contributor.authorSıddıkoğlu, Duygu
dc.date.accessioned2024-07-19T06:25:07Z
dc.date.available2024-07-19T06:25:07Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractBackground: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases. Aims and Objectives: The present study aims to evaluate the relationship of these cytokines with rosacea. Materials and Methods: A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants. Results: The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 ± 24.07 pg/ml, 18.46 ± 8.18 pg/ml, and 25.74 ± 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 ± 19.90 pg/ml, 44.61 ± 22.27 pg/ml, and 45.61 ± 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant (P < 0.001). Conclusion: Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea.
dc.identifier.citationEkinci, A., Oğuz Kılıç, S., Demir, N. ve Sıddıkoğlu, D. (2024). Important roles of interleukin-36, interleukin-37, and interleukin-38 cytokines in the pathogenesis of rosacea. Indian Journal of Dermatology, 69(3), 232-237. http://dx.doi.org/10.4103/ijd.ijd_470_23
dc.identifier.doi10.4103/ijd.ijd_470_23
dc.identifier.endpage237
dc.identifier.issn0019-5154
dc.identifier.issue3
dc.identifier.pmid39119329
dc.identifier.scopus2-s2.0-85197577500
dc.identifier.scopusqualityQ3
dc.identifier.startpage232
dc.identifier.urihttp://dx.doi.org/10.4103/ijd.ijd_470_23
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12732
dc.identifier.volume69
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOğuz Kılıç, Sevilay
dc.language.isoen
dc.relation.ispartofIndian Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInflammation
dc.subjectInterleukin-36
dc.subjectInterleukin-37
dc.subjectInterleukin-38
dc.subjectRosacea
dc.titleImportant roles of interleukin-36, interleukin-37, and interleukin-38 cytokines in the pathogenesis of rosacea
dc.typeArticle

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