Impact of pre-operative ureteroscopy on bladder recurrence following nephroureterectomy for utuc

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dc.authorid0000-0003-0906-4417
dc.authorid0000-0002-6308-1763
dc.contributor.authorWong, Chris Ho Ming
dc.contributor.authorKo, Ivan Ching Ho
dc.contributor.authorLeung, David Ka Wai
dc.contributor.authorLiu, Kang
dc.contributor.authorZhao, Hongda
dc.contributor.authorAlvarez Maestro, Mario
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorTeoh, Jeremy Yuen Chun
dc.date.accessioned2024-09-23T08:34:19Z
dc.date.available2024-09-23T08:34:19Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstract(1) Introduction: Diagnostic ureteroscopy (URS) is an important component in the workup of upper tract urothelial carcinoma (UTUC). Whether URS was associated with increased recurrence in the bladder was not fully concluded. The current study aimed to evaluate the implication of URS on the incidences of intravesical recurrence following radical nephroureterectomy (RNU) in non-metastatic UTUC patients without prior history of bladder cancer via multi-institutional data. (2) Patients and Methods: Data were obtained from the Clinical Research Office of the Endourology Society Urothelial Carcinomas of the Upper Tract (CROES-UTUC) registry, a prospective, multicentre database. Patients with non-metastatic UTUC treated with RNU were divided into two groups: those undergoing upfront RNU and those having diagnostic URS prior to RNU. Intravesical recurrence-free survival (IVRS) was the primary endpoint, evaluated through Kaplan–Meier analysis and multivariate Cox regression. Cases with adequate follow-up data were included. (3) Results: The analysis included 269 patients. Of these, 137 (50.9%) received upfront RNU and 132 (49.1%) received pre-RNU URS. The URS group exhibited an inferior 24-month IVRS compared to the upfront RNU group (HR = 1.705, 95% CI = 1.082–2.688; p = 0.020). Multivariate analysis confirmed URS as the only significant predictor of IVR (p = 0.019). Ureteric access sheath usage, flexible ureteroscopy, ureteric biopsy, retrograde contrast studies, and the duration of URS did not significantly affect IVRS. (4) Conclusions: Diagnostic URS prior to RNU was found to be associated with an increased risk of IVR in patients with UTUC. The risk was not significantly influenced by auxiliary procedures during URS. Physicians were advised to meticulously evaluate the necessity of diagnostic URS.
dc.description.sponsorshipSTORZ; General Research Fund/Early Career Scheme of the Research Grants Council, Hong Kongen_US
dc.identifier.citationWong, C. H. M., Ko, I. C. H., Leung, D. K. W., Liu, K., Zhao, H., Alvarez Maestro, M. ... Teoh, J. Y. C. (2024). Impact of pre-operative ureteroscopy on bladder recurrence following nephroureterectomy for utuc. Cancers, 16(15). http://dx.doi.org/10.3390/cancers16152683
dc.identifier.doi10.3390/cancers16152683
dc.identifier.issn2072-6694
dc.identifier.issue15
dc.identifier.pmid39123411
dc.identifier.scopus2-s2.0-85200742643
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.3390/cancers16152683
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12824
dc.identifier.volume16
dc.identifier.wos001287079000001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/14117421
dc.relation.ispartofCancersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBladder Recurrence
dc.subjectNephroureterectomy
dc.subjectSurvival Outcomes
dc.subjectUpper Tract Urothelial Carcinoma
dc.subjectUreteroscopy
dc.titleImpact of pre-operative ureteroscopy on bladder recurrence following nephroureterectomy for utuc
dc.typeArticle

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