Wnt signaling pathway in early- and late-onset preeclampsia: Evaluation with Dickkopf-1 and R-Spondin-3 glycoproteins

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dc.authorid0000-0003-1257-8742
dc.contributor.authorTayyar, Ahter Tanay
dc.contributor.authorKarakuş, Resul
dc.contributor.authorEraslan Şahin, Mefkure
dc.contributor.authorTopbaş, Nura Fitnat
dc.contributor.authorŞahin, Erdem
dc.contributor.authorKarakuş, Seren
dc.contributor.authorYalçın, Emel Tuğçe
dc.contributor.authorTayyar, Ahmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:33Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000468754900006
dc.descriptionPubMed ID: 30905002
dc.description.abstractObjective Wnt signaling has been identified as an essential pathway that can direct cell proliferation, migration, and tissue homeostasis. This study aimed to evaluate the role of Wnt signaling pathway in early-onset and late-onset preeclampsia (PE) using serum Dickkopf-1 and R-Spondin-3 glycoproteins. Study design A total of 80 pregnant women were included in this study. The patients were divided into three groups: (1) control (2) early-onset PE, and (3) late-onset PE. The serum levels of Dickkopf-1 and R-Spondin-3 were measured using an enzyme-linked immunosorbent assay. Results Of the 80 pregnant women enrolled in the study, 27 were control, 27 had early-onset PE, and 26 had late-onset PE. No differences were found in the maternal age, gravida, parity, and body mass index among the groups (P = 0.536, 0.230, 0.202, and 0.642, respectively). The serum level of Dickkopf-1 was significantly higher in the early-onset PE group compared with the control group (P = 0.006). The serum level of Dickkopf-1 was statistically similar in control group compared to lateonset PE group (P = 0.064). However, no significant difference was found in the serum levels of Dickkopf-1 and R-Spondin-3 between the early-and late-onset PE groups (P> 0.05). Additionally, the Spearman's correlation analysis revealed a significant negative correlation between maternal serum level of Dickkopf-1 and maternal age (r =- 0.522, P = 0.005). Conclusion The increased serum level of Dickkopf-1 might be associated with the process of pathogenesis of early-onset PE. Further studies would elucidate their exact roles in the pathogenesis of PE.
dc.identifier.citationTayyar, A. T., Karakuş, R., Eraslan Şahin, M., Topbaş, N. F., Şahin, E., Karakuş, S. ... Tayyar, A. (2019). Wnt signaling pathway in early- and late-onset preeclampsia: Evaluation with Dickkopf-1 and R-Spondin-3 glycoproteins. Archives of Gynecology and Obstetrics, 299(6), 1551-1556. https://dx.doi.org/10.1007/s00404-019-05126-8
dc.identifier.doi10.1007/s00404-019-05126-8
dc.identifier.endpage1556
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage1551
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-019-05126-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1640
dc.identifier.volume299
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDickkopf-1
dc.subjectEarly-Onset Preeclampsia
dc.subjectLate-Onset Preeclampsia
dc.subjectR-Spondin-3
dc.subjectWnt Signaling Pathway
dc.titleWnt signaling pathway in early- and late-onset preeclampsia: Evaluation with Dickkopf-1 and R-Spondin-3 glycoproteins
dc.typeArticle

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