A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma
| dc.authorid | 0000-0002-7885-0537 | |
| dc.authorid | 0000-0001-5057-0405 | |
| dc.authorid | 0000-0002-7022-913X | |
| dc.contributor.author | Do?a Üstüner, Pelin | |
| dc.contributor.author | Balevi, Ali | |
| dc.contributor.author | Özdemir, Mustafa | |
| dc.date.accessioned | 2020-07-20T06:41:34Z | |
| dc.date.available | 2020-07-20T06:41:34Z | |
| dc.date.issued | 2017 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı | |
| dc.description.abstract | Background: High recurrence has previously been reported in the treatment of melasma with low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QS-Nd:YAG) laser. On the other hand, the efficacy and safety of the QS-Nd:YAG laser plus microneedling with vitamin C have not been evaluated in patients with mixed-type melasma. Material and methods: Sixteen patients with recalcitrant dermal- or mixed-type melasma were included in the study. One side of patients’ face was treated with QS-Nd:YAG laser plus microneedling with vitamin C (Group A) and the other side with QS-Nd:YAG laser alone (Group B) for four sessions at four-week intervals. Melasma Area Severity Index (MASI) scores and clinician’s evaluation of clinical response were assessed monthly. Results: Group A had a significantly lower mean MASI score and better treatment response than Group B according to clinician’s evaluation. According to MASI scores, in Group B, two patients had a good response while 12 were unresponsive to treatment. Good or very good improvement was reported by 10 patients in Group A and three patients in Group B. Adverse effects and recurrence rates were similar in Groups A and B (31.3 and 43.8%, respectively). Discussion: QS-Nd:YAG increases the blood circulation in the dermis, thereby enhancing the mechanical effect of microneedling to promote the penetration of vitamin C. Conclusion: Vitamin C application with microneedling immediately after treatment with QS-Nd:YAG laser is a promising adjunctive method for the treatment of recalcitrant melasma. | |
| dc.identifier.citation | Do?a Üstüner, P., Balevi, A. ve Özdemir, M. (2017). A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma. Journal of Cosmetic and Laser Therapy, 19(7), 383-390. https://dx.doi.org/10.1080/14764172.2017.1342036 | |
| dc.identifier.doi | 10.1080/14764172.2017.1342036 | |
| dc.identifier.endpage | 390 | |
| dc.identifier.issn | 1476-4172 | |
| dc.identifier.issn | 1476-4180 | |
| dc.identifier.issue | 7 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 383 | |
| dc.identifier.uri | https://dx.doi.org/10.1080/14764172.2017.1342036 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5566 | |
| dc.identifier.volume | 19 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.relation.ispartof | Journal of Cosmetic and Laser Therapy | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Melasma | |
| dc.subject | Microneedling | |
| dc.subject | Q-Switched Lasers | |
| dc.subject | Vitamin C | |
| dc.title | A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma | |
| dc.type | Article |
