Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

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dc.authorid0000-0002-0022-0439
dc.contributor.authorKömür, Baran Heval
dc.contributor.authorBayrak, Ferda
dc.contributor.authorEkren, Nazmi
dc.contributor.authorEroğlu, Mehmet Sayıp
dc.contributor.authorOktar, Faik Nüzhet
dc.contributor.authorAydın Sinirlioğlu, Zeynep
dc.contributor.authorYücel, Sevil
dc.contributor.authorGüler, Olcay
dc.contributor.authorGündüz, Oğuzhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:41Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:41Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.description.abstractBackground: In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application. Results: The effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability. Conclusions: Composite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail.
dc.identifier.citationKömür, B. H., Bayrak, F., Ekren, N., Eroğlu, M. S., Oktar, F. N., Aydın Sinirlioğlu, Z. ... Gündüz, O. (2017). Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications. BioMedical Engineering Online, 16. https://dx.doi.org/10.1186/s12938-017-0334-y
dc.identifier.doi10.1186/s12938-017-0334-y
dc.identifier.issn1475-925X
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1453
dc.identifier.urihttps://dx.doi.org/10.1186/s12938-017-0334-y
dc.identifier.volume16
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.relation.ispartofBioMedical Engineering Onlineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsCC0 1.0 Universal (CC0 1.0) Public Domain Dedication*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectNanofiber
dc.subjectElectrospinning
dc.subjectStarch
dc.subjectPCL
dc.subjectWound Dressing
dc.titleStarch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications
dc.typeArticle

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