A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl

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dc.authorid0000-0002-4479-2586
dc.authorid0000-0003-0352-1947
dc.authorid0000-0002-7059-1884
dc.contributor.authorDemircan, Turan
dc.contributor.authorİlhan, Ayşe Elif
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorYıldırım, Berna
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorKeskin, İlknur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:27Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:27Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractAxolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to metamorphosis with thyroid hormones (THs) treatment advances the utilization of Axolotl in various studies. It has been reported that amphibians undergo anatomical and histological remodeling during metamorphosis and this transformation is crucial for adaptation to terrestrial conditions. However, there is no comprehensive histological investigation regarding the morphological alterations of Axolotl organs and tissues throughout the metamorphosis. Here, we reveal the histological differences or resemblances between the neotenic and metamorphic axolotl tissues. In order to examine structural features and cellular organization of Axolotl organs, we performed Hematoxylin & Eosin, Luxol-Fast blue, Masson's trichrome, Alcian blue, Orcein and Weigart's staining. Stained samples from brain, gallbladder, heart, intestine, liver, lung, muscle, skin, spleen, stomach, tail, tongue and vessel were analyzed under the light microscope. Our findings contribute to the validation of the link between newly acquired functions and structural changes of tissues and organs as observed in tail, skin, gallbladder and spleen. We believe that this descriptive work provides new insights for a better histological understanding of both neotenic and metamorphic Axolotl tissues.
dc.identifier.citationDemircan, T., İlhan, A. E., Aytürk, N., Yıldırım, B., Öztürk, G. ve Keskin, İ. (2016). A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl. Acta Histochemica, 118(7), 746-759. https://dx.doi.org/10.1016/j.acthis.2016.07.006
dc.identifier.doi10.1016/j.acthis.2016.07.006
dc.identifier.endpage759
dc.identifier.issn0065-1281
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage746
dc.identifier.urihttps://hdl.handle.net/20.500.12511/788
dc.identifier.urihttps://dx.doi.org/10.1016/j.acthis.2016.07.006
dc.identifier.volume118
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier GmbH
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAxolotl
dc.subjectHistological Map
dc.subjectMetamorphosis
dc.subjectNeoteny
dc.subjectThyroid Hormones
dc.titleA histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
dc.typeArticle

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