HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA

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dc.authorid0000-0001-8945-2385
dc.contributor.authorSili, Uluhan
dc.contributor.authorKaya, Abdurrahman
dc.contributor.authorAydın, Selda
dc.contributor.authorHondur, Nur
dc.contributor.authorMert, Ali
dc.contributor.authorTabak, Fehmi
dc.contributor.authorÖzaras, Reşat
dc.contributor.authorÖztürk, Recep
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:45Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000354124400016
dc.descriptionPubMed ID: 25959163
dc.description.abstractBackground: Hepatitis C virus (HCV) status cannot be reliably predicted in anti-HCV positive/HCV-RNA negative individuals who may either have recovered spontaneously or have a false-positive test due to antibody cross-reaction. Investigating T lymphocyte responses in individuals with different HCV status may help understand the cellular immune mechanisms underlying spontaneous recovery, treatment response, and chronicity. Objective: We aimed to determine whether anti-HCV positive, HCV-RNA negative individuals are truly spontaneous recoverers from acute HCV infection. Study design: We used enzyme-linked immunosorbent spot (ELISPOT) assay to compare HCV-specific lymphocyte response among anti-HCV positive/HCV-RNA negative individuals, patients with sustained virological response to interferon-gamma/ribavirin treatment, and patients with chronic HCV infection. Results: We found that 83% of anti-HCV positive/HCV-RNA negative individuals without a past medical history of acute icteric hepatitis had an HCV-specific T lymphocyte response in peripheral blood. Lymphocyte responses in these individuals were similar in magnitude to treatment responders unlike patients with chronic HCV whose virus-directed immunity was significantly suppressed. Conclusions: Detection of HCV-specific T lymphocyte responses using ELISPOT is a feasible method to ascertain past asymptomatic acute HCV infection.
dc.description.sponsorshipOffice of Scientific Research Projects, Istanbul University [BYPS-1-26/31012007]en_US
dc.description.sponsorshipThis study is funded in part by the Office of Scientific Research Projects, Istanbul University (no: BYPS-1-26/31012007).en_US
dc.identifier.citationSili, U., Kaya, A., Aydın, S., Hondur, N., Mert, A., Tabak, F. ... Öztürk, R. (2015). HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA. Journal of Clinical Virology, 67, 73-77. https://dx.doi.org/10.1016/j.jcv.2015.04.014
dc.identifier.doi10.1016/j.jcv.2015.04.014
dc.identifier.endpage77
dc.identifier.issn1386-6532
dc.identifier.issn1873-5967
dc.identifier.scopusqualityQ1
dc.identifier.startpage73
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcv.2015.04.014
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3042
dc.identifier.volume67
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science
dc.relation.ispartofJournal of Clinical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHCV
dc.subjectT-lymphocyte
dc.subjectSpontaneous Recovery
dc.subjectElispot
dc.subjectFalse-Positive Serology
dc.titleHCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA
dc.typeArticle

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