Essential oil composition of isatis floribunda boiss. ex. bornm. and acetylcholinesterase inhibitory activity of its extract

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dc.authorid0000-0002-2737-0568
dc.contributor.authorGüzel, Elif
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorAlkan, Mustafa
dc.contributor.authorPolatoğlu, Kaan
dc.date.accessioned2024-08-27T10:48:51Z
dc.date.available2024-08-27T10:48:51Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractThis study aims to investigate the essential oil composition of aerial parts of Isatis floribunda, and the acetylcholinesterase inhibitory activity of its extracts. Essential oil of the aerial parts of the plant material was obtained and the GC-MS analysis was performed. Then, extracts of the plant material were obtained, and in vitro acetylcholinesterase inhibitory assay was performed. GC-MS analysis demonstrated that the composition of Isatis floribunda is rich in fatty acid compounds, with the major compounds including dodecanoic acid, nanocosane, hexadecenoic acid, tetradecanoic acid, methyl octadecenoate, decanoic acid, and hexahydrofarnesyl acetone. Methanolic extract of the plant species has demonstrated strong acetylcholinesterase inhibitory activity with the IC50 value of 0.16 mg/mL. Essential oil composition of Isatis floribunda has been determined to be rich in fatty acid components, these compounds could demonstrate potent acetylcholinesterase inhibition. Therefore, a novel medication from Isatis floribunda extracts could be discovered against Alzheimer’s disease.
dc.identifier.citationGüzel, E., Yücel, Y. Y., Alkan, M. ve Polatoğlu, K. (2024). Essential oil composition of isatis floribunda boiss. ex. bornm. and acetylcholinesterase inhibitory activity of its extract. Acta Pharmaceutica Sciencia, 62(3), 581-592. http://dx.doi.org/10.23893/1307-2080.APS6237
dc.identifier.doi10.23893/1307-2080.APS6237
dc.identifier.endpage592
dc.identifier.issn1307-2080
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85199385693
dc.identifier.scopusqualityQ3
dc.identifier.startpage581
dc.identifier.urihttp://dx.doi.org/10.23893/1307-2080.APS6237
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12779
dc.identifier.volume62
dc.indekslendigikaynakScopus
dc.institutionauthorGüzel, Elif
dc.language.isoen
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcetylcholinesterase Inhibition
dc.subjectBrassicaceae
dc.subjectGC-MS
dc.subjectIsatis Floribunda
dc.titleEssential oil composition of isatis floribunda boiss. ex. bornm. and acetylcholinesterase inhibitory activity of its extract
dc.typeArticle

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