The effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury

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dc.authorid0000-0002-6984-3079
dc.contributor.authorAktaş, Abit
dc.contributor.authorYiğit, Funda
dc.contributor.authorDelibaş, Burcu
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorHamour, Hala Mahgoub
dc.contributor.authorMarangoz, Abdullah Hilmi
dc.contributor.authorKaya, Ayşenur
dc.contributor.authorAltun, Gamze
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2024-02-29T05:44:39Z
dc.date.available2024-02-29T05:44:39Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: To test the protective effects of Garcinia kola and curcumin on the ganglion tissues of diabetic rats following the use of autologous vein graft in peripheral nerve transection injury. Methods: The sciatic nerve on the right side was transected, and anastomosis was performed between the proximal and distal ends using an autologous vein graft. Curcumin and Garcinia kola seed extract were administered daily by oral gavage. The ganglion tissues were harvested after a 90-day waiting period. Sensory neurons in the dorsal root ganglion at the L4 and L5 levels were used for stereological evaluations. Mean sensory neuron numbers were analyzed using a stereological technique. The size of the light and dark neurons was also estimated, and ultrastructural and immunohistochemical evaluations were performed. Results: A statistically significant difference in sensory neuron numbers was observed between the groups with and without Garcinia kola and curcumin applications. The immunohistochemical results showed that the s-100 protein is expressed selectively between cell types. Conclusion: The results of this study show that curcumin and Garicinia kola prevented sensory neuron loss in diabetic rats following transection injury to the sciatic nerve.
dc.identifier.citationAktaş, A., Yiğit, F., Delibaş, B., Kaplan, A. A., Hamour, H. M., Marangoz, A. H. ... Kaplan, S. (2024). The effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury. Journal of Chemical Neuroanatomy, 136. https://dx.doi.org/10.1016/j.jchemneu.2024.102395
dc.identifier.doi10.1016/j.jchemneu.2024.102395
dc.identifier.issn1873-6300
dc.identifier.issn0891-0618
dc.identifier.pmid38320670
dc.identifier.scopus2-s2.0-85184612559
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://dx.doi.org/10.1016/j.jchemneu.2024.102395
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12320
dc.identifier.volume136
dc.identifier.wos001184048100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Arife Ahsen
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDiabetic Neuropathy
dc.subjectDorsal Root Ganglion
dc.subjectPhysical Disector
dc.subjectSciatic Nerve Transection Injury
dc.subjectStereology
dc.titleThe effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury
dc.typeArticle

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