Association of the naples prognostic score with long-term adverse events in chronic limb-threatening ischemia after below-the-knee endovascular revascularization

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dc.contributor.authorDerviş, Emir
dc.contributor.authorHakgör, Aykun
dc.contributor.authorGöksu, Muhammed Mert
dc.contributor.authorYakut, İdris
dc.contributor.authorKönte, Hasan Can
dc.contributor.authorPanç, Cafer
dc.contributor.authorErtürk, Mehmet
dc.date.accessioned2025-12-09T11:33:24Z
dc.date.available2025-12-09T11:33:24Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractObjectives: Chronic limb-threatening ischemia (CLTI) is the most severe manifestation of peripheral artery disease (PAD) and is associated with high morbidity and mortality. The Naples prognostic score (NPS), a composite marker incorporating serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), has shown prognostic value in various cardiovascular conditions. This study aimed to evaluate the prognostic significance of the NPS in predicting all-cause mortality and any kind of amputation in patients with CLTI undergoing endovascular treatment (EVT) for below-the-knee (BTK) lesions. Methods: In this retrospective analysis, 191 patients diagnosed with CLTI and treated with EVT for BTK lesions between 2017 and 2023 were stratified into three groups based on the NPS: low (0–1), intermediate (2), and high (3–4). The primary endpoint was all-cause mortality, while the secondary endpoint was any kind of amputation. Results: A higher NPS was significantly associated with increased all-cause mortality (hazard ratio: 3.66; 95% confidence interval: 1.72–7.78; p < 0.001), while no significant association was observed between the NPS and major amputation. Independent predictors of mortality included a high NPS, reduced left ventricular ejection fraction, and impaired renal function. Conclusions: The NPS is an independent predictor of long-term mortality in CLTI patients undergoing EVT for BTK lesions.
dc.identifier.citationDerviş, E., Hakgör, A., Göksu, M. M., Yakut, İ., Konte, H. C., Panç, C. ... Ertürk, M. (2024). Association of the naples prognostic score with long-term adverse events in chronic limb-threatening ischemia after below-the-knee endovascular revascularization. Diagnostics, 14(23). http://dx.doi.org/10.3390/diagnostics14232627
dc.identifier.doi10.3390/diagnostics14232627
dc.identifier.issn2075-4418
dc.identifier.issue23
dc.identifier.pmid39682536
dc.identifier.scopus2-s2.0-85212214025
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.3390/diagnostics14232627
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13312
dc.identifier.volume14
dc.identifier.wosWOS:001377328400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDerviş, Emir
dc.institutionauthorHakgör, Aykun
dc.institutionauthorKönte, Hasan Can
dc.institutionauthorErtürk, Mehmet
dc.institutionauthorid0000-0003-3221-2166
dc.institutionauthorid0000-0001-8252-0373
dc.institutionauthorid0000-0001-9321-5673
dc.language.isoen
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdverse Events
dc.subjectChronic Limb-Threatening Ischemia
dc.subjectMortality
dc.subjectNaples Prognostic Score
dc.subjectPeripheral Arterial Disease
dc.titleAssociation of the naples prognostic score with long-term adverse events in chronic limb-threatening ischemia after below-the-knee endovascular revascularization
dc.typeArticle

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