The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy

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dc.contributor.authorBaşaranoğlu, Serdar
dc.contributor.authorAğaçayak, Elif
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorYaman Tunç, Senem
dc.contributor.authorDeregözü, Ayşegül
dc.contributor.authorAkkurt, Zeynep Meltem
dc.contributor.authorPeker, Nurullah
dc.contributor.authorAcet, Mustafa
dc.contributor.authorYüksel, Hatice
dc.contributor.authorGül, Talip
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:27Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:27Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000402366100010
dc.descriptionPubMed ID: 27049609
dc.description.abstractAim: The present study aimed to determine the levels of total cholesterol, triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and vitamins B1 and B2 in intrahepatic cholestasis of pregnancy (ICP) patients, and to evaluate if these were involved in the pathophysiology of the disease. Methods: The prospective randomized study included 35 pregnant patients who were admitted to the Gynecology and Obstetrics Polyclinic, Faculty of Medicine at Dicle University and who were diagnosed with ICP (Group 1), and 40 healthy pregnant women who were admitted in the same period and who had no systemic diseases that might complicate the pregnancy during the pregnancy follow-up (Group 2). Serum lipid levels and vitamins B1 and B2 were determined and compared, and statistical comparisons of the groups were made. Results: There was no difference between the TG levels of the two groups (P=0.631). Total cholesterol, LDL, HDL, and vitamin B1 and B2 levels were higher in Group 1 than in Group 2 (P=0.001, P=0.001, P=0.001, P=0.001, and P=0.032, respectively). Conclusions: Increased levels of vitamins B1 and B2 may indicate a need for increased energy metabolism at the fetus. So we believe that new studies are required, which will be supported by the placental analyses of the pyruvate and lactate levels in maternal blood at delivery and fetal cord blood in order to develop a better understanding on the fetal effects of energy metabolism.
dc.identifier.citationBaşaranoğlu, S., Ağaçayak, E., Uçmak, F., Yaman Tunç, S., Deregözü, A., Akkurt, Z. M. ... Gül,T. (2017). The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy. Journal of Perinatal Medicine, 45(4), 461-465. https://dx.doi.org/10.1515/jpm-2015-0337
dc.identifier.doi10.1515/jpm-2015-0337
dc.identifier.endpage465
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage461
dc.identifier.urihttps://dx.doi.org/10.1515/jpm-2015-0337
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3278
dc.identifier.volume45
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter de Gruyter Gmbh
dc.relation.ispartofJournal of Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCholestasis
dc.subjectLipids
dc.subjectPregnancy
dc.subjectVitamin B1
dc.subjectVitamin B2
dc.titleThe role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy
dc.typeArticle

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