Comparing postoperative pain relief: ketorolac and nasocalcin spray versus lidocaine and nasocalcin spray in abdominal surgery patients

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dc.contributor.authorFakhr, Masoud Saadat
dc.contributor.authorQasemi, Mahdiya
dc.contributor.authorRezvanfar, Kiana
dc.contributor.authorHosseini, Reza Shah
dc.contributor.authorAmini, Zahra
dc.contributor.authorAmiri, Koosha
dc.contributor.authorZamanabadi, Mahnaz Narimani
dc.date.accessioned2025-09-30T06:51:08Z
dc.date.available2025-09-30T06:51:08Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractObjectives: Postoperative pain management is critical for patient recovery after abdominal surgery. This study compared intravenous lidocaine and ketorolac for reducing postoperative pain and opioid use, along with Nasocalcin nasal spray. Methods: In this randomized controlled trial, 58 abdominal surgery patients were allocated to receive either intravenous lidocaine plus Nasocalcin spray (n=29) or intravenous ketorolac plus Nasocalcin spray (n=29) before surgery. Pain intensity (visual analog scale) and postoperative opioid consumption were assessed at 1, 6, 12, and 24 h after surgery. Results: Patients receiving ketorolac plus Nasocalcin spray reported significantly lower pain scores at all time points compared to lidocaine plus Nasocalcin (P<0.001). Average 24-h pain scores were 4.5 with ketorolac versus 5.1 with lidocaine. Mean opioid consumption was also lower in the ketorolac group (31.9 mg) versus the lidocaine group (43.9 mg, P<0.001). Conclusion: Preoperative ketorolac plus Nasocalcin nasal spray resulted in superior pain relief and less opioid use compared to lidocaine plus Nasocalcin after abdominal surgery. Ketorolac may be a more effective analgesic option, while Nasocalcin spray is a safe adjunct. These findings can inform clinical practice for optimizing postoperative analgesia.
dc.identifier.citationFakhr, M. S., Qasemi, M., Rezvanfar, K., Hosseini, R. S., Amini, Z., Amiri, K. ... Zamanabadi, M. N. (2024). Comparing postoperative pain relief: ketorolac and nasocalcin spray versus lidocaine and nasocalcin spray in abdominal surgery patients. Annals of Medicine and Surgery, 86(10), 5823-5829. http://dx.doi.org/10.1097/MS9.0000000000002285
dc.identifier.doi10.1097/MS9.0000000000002285
dc.identifier.endpage5829
dc.identifier.issn2049-0801
dc.identifier.issue10
dc.identifier.pmid39359836
dc.identifier.startpage5823
dc.identifier.urihttp://dx.doi.org/10.1097/MS9.0000000000002285
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13052
dc.identifier.volume86
dc.identifier.wosWOS:001326658800015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorHosseini, Reza Shah
dc.language.isoen
dc.relation.ispartofAnnals of Medicine and Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAbdominal Surgery
dc.subjectKetorolac
dc.subjectLidocaine
dc.subjectNasocalcin Spray
dc.subjectPain Management
dc.titleComparing postoperative pain relief: ketorolac and nasocalcin spray versus lidocaine and nasocalcin spray in abdominal surgery patients
dc.typeArticle

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