The effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistribution

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dc.authorid0000-0002-8662-5284
dc.authorid0000-0001-8759-745X
dc.contributor.authorÖzçiçek, İlyas
dc.contributor.authorAyşit, Neşe
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorUlaş Aytürk, Nilüfer
dc.contributor.authorAydeğer, Asel
dc.contributor.authorErim, Ümit Can
dc.date.accessioned2022-02-02T07:51:17Z
dc.date.available2022-02-02T07:51:17Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractWith the development of gold nanorods (AuNRs) for a number of biomedical applications, understanding their various biological effects has become important. Surface functionalization of AuNRs is attracting increasing attention with regard to toxicity, cellular uptake, localization, therapeutic potential, and biodistribution. The aim of the study is to synthesis of stable AuNRs functionalized with polyethylenimine (PEI) and polyethylene glycol (PEG), multiparametric investigation of their cellular effects on the dorsal root ganglion (DRG) primary sensory neurones, evaluation of the in vitro/in vivo biodistribution, and toxicity. PEI and PEG surface coatings increased both biocompatibility and biodistribution of the AuNRs. With the near-infrared laser of the two-photon microscope, very strong radiations are taken from the nucleolus parts of the neurones particularly and these localizations of the AuNRs-PEI are confirmed by the transmission electron microscope images. Inductively coupled plasma mass spectrometry analysis shows the presence of AuNRs in liver, spleen, kidney, heart, blood, and brain within a 30 day period. It is observed that the surface coatings of the AuNRs significantly increase the biodistribution and biocompatibility. The surface functionalization, stability, and biocompatibility of the AuNRs are very important parameters for the potential nanotheranostic applications of AuNRs in the next studies.
dc.identifier.citationÖzçiçek, İ., Ayşit, N., Çakıcı, Ç., Ulaş Aytürk, N., Aydeğer, A. ve Erim, Ü. C. (2022). The effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistribution. Advanced Materials Interfaces, 9(3). https://dx.doi.org/10.1002/admi.202101369
dc.identifier.doi10.1002/admi.202101369
dc.identifier.issn2196-7350
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1002/admi.202101369
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8949
dc.identifier.volume9
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAdvanced Materials Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/217S135
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBiodistribution
dc.subjectCellular Localization
dc.subjectDorsal Root Ganglion Sensory Neurones
dc.subjectGold Nanorods
dc.subjectNanotoxicity
dc.subjectPolyethylenimine
dc.subjectPolyethylene Glycol
dc.subjectSurface Functionalization
dc.titleThe effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistribution
dc.typeArticle

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