Molecular biomarkers in the context of focal therapy for prostate cancer: Recommendations of a delphi consensus from the focal therapy society

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dc.authorid0000-0003-0906-4417
dc.authorid0000-0002-6308-1763
dc.contributor.authorMarra, Giancarlo
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorWalz, Jochen
dc.contributor.authorPavlovich, Christian P.
dc.contributor.authorBianco, Fernando
dc.contributor.authorGregg, Justin
dc.contributor.authorLebastchi, Amir H.
dc.contributor.authorLepor, Herbert
dc.contributor.authorMacek, Petr
dc.contributor.authorRais-Bahrami, Soroush
dc.contributor.authorRobertson, Cary
dc.contributor.authorRukstalis, Daniel
dc.contributor.authorSalomon, Georg
dc.contributor.authorUkimura, Osamu
dc.contributor.authorAbreu, Andre L.
dc.contributor.authorBarbe, Yann
dc.contributor.authorCathelineau, Xavier
dc.contributor.authorGandaglia, Giorgio
dc.contributor.authorGeorge, Arvin K.
dc.contributor.authorGomez Rivas, Juan
dc.contributor.authorGupta, Rajan T.
dc.contributor.authorLawrentschuk, Nathan
dc.contributor.authorKasivisvanathan, Veeru
dc.contributor.authorLomas, Derek
dc.contributor.authorMalavaud, Bernard
dc.contributor.authorMargolis, Daniel
dc.contributor.authorMatsuoka, Yoh
dc.contributor.authorMehralivand, Sherif
dc.contributor.authorMoschini, Marco
dc.contributor.authorOderda, Marco
dc.contributor.authorOrabi, Hazem
dc.contributor.authorRastinehad, Ardeshir R.
dc.contributor.authorRemzi, Mesut
dc.contributor.authorSchulman, Ariel
dc.contributor.authorShin, Toshitaka
dc.contributor.authorShiraishi, Takumi
dc.contributor.authorSidana, Abhinav
dc.contributor.authorShoji, Sunao
dc.contributor.authorStabile, Armando
dc.contributor.authorValerio, Massimo
dc.contributor.authorTammisetti, Varaha S.
dc.contributor.authorPhin Tan, Wei
dc.contributor.authorvan Den Bos, Willemien
dc.contributor.authorVillers, Arnaud
dc.contributor.authorWillemse, Peter-Paul
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorPolascik, Thomas
dc.contributor.authorSanchez-Salas, Rafael
dc.date.accessioned2022-10-07T08:49:42Z
dc.date.available2022-10-07T08:49:42Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractBACKGROUND: Focal therapy (FT) for prostate cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men undergoing FT, though there is limited evidence in this field to guide practice. We aimed to conduct a consensus meeting, endorsed by the Focal Therapy Society, amongst a large group of experts, to understand the potential utility of MB in FT for localized PCa. METHODS: A 38-item questionnaire was built following a literature search. The authors then performed three rounds of a Delphi Consensus using DelphiManager, using the GRADE grid scoring system, followed by a face-to-face expert meeting. Three areas of interest were identified and covered concerning MB for FT, 1) the current/present role; 2) the potential/future role; 3) the recommended features for future studies. Consensus was defined using a 70% agreement threshold. RESULTS: Of 95 invited experts, 42 (44.2%) completed the three Delphi rounds. Twenty-four items reached a consensus and they were then approved at the meeting involving (N.=15) experts. Fourteen items reached a consensus on uncertainty, or they did not reach a consensus. They were re-discussed, resulting in a consensus (N.=3), a consensus on a partial agreement (N.=1), and a consensus on uncertainty (N.=10). A final list of statements were derived from the approved and discussed items, with the addition of three generated statements, to provide guidance regarding MB in the context of FT for localized PCa. Research efforts in this field should be considered a priority. CONCLUSIONS: The present study detailed an initial consensus on the use of MB in FT for PCa. This is until evidence becomes available on the subject.
dc.identifier.citationMarra, G., del Pilar Laguna Pes, M., Walz, J., Pavlovich, C. P., Bianco, F., Gregg, J. ... Sanchez-Salas, R. (2022). Molecular biomarkers in the context of focal therapy for prostate cancer: Recommendations of a delphi consensus from the focal therapy society. Minerva Urology and Nephrology, 74(5), 581-589. https://doi.org/10.23736/S2724-6051.20.04160-0
dc.identifier.doi10.23736/S2724-6051.20.04160-0
dc.identifier.endpage589
dc.identifier.issn2724-6051
dc.identifier.issn2724-6442
dc.identifier.issue5
dc.identifier.pmid33439577
dc.identifier.scopus2-s2.0-85138458374
dc.identifier.scopusqualityQ1
dc.identifier.startpage581
dc.identifier.urihttps://doi.org/10.23736/S2724-6051.20.04160-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9808
dc.identifier.volume74
dc.identifier.wos000878092300011en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofMinerva Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarkers
dc.subjectTumor
dc.subjectDelphi Technique
dc.subjectProstatic Neoplasms Cancer
dc.titleMolecular biomarkers in the context of focal therapy for prostate cancer: Recommendations of a delphi consensus from the focal therapy society
dc.typeArticle

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