Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats

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dc.authorid0000-0001-6494-8923
dc.contributor.authorAkkaya, Hatice
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorEyüboğlu Dinç, Siğnem
dc.contributor.authorYılmaz, Bayram
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:25Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000340532800004
dc.descriptionPubMed ID: 24863683
dc.description.abstractApart from its effect on the regulation of reproductive function, recent studies indicate that kisspeptin may play roles in the antioxidant defense system. The antioxidant defense system and oxidative stress contribute to the etiology and pathogenesis of neuronal cell death after brain injury. We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine. DNA fragmentation, malondialdehyde (MDA), reduced glutathione levels, and superoxide dismutase (SOD) activities were analyzed. Our results showed that methionine treatment increases apoptotic cell death. Kisspeptin alone showed no side effect on apoptotic cell death. However, kisspeptin treatment reversed the proapoptotic effect of methionine associated with reduced MDA and increased glutathione levels. Furthermore, SOD activity was completely depleted in methionine-treated animals. In conclusion, our results revealed that delayed kisspeptin-10 treatment reduces neuronal cell death by activation of SOD activity.
dc.description.sponsorshipTurkish Academy of Sciences (TUBA/GEBIP/EK)en_US
dc.description.sponsorshipContract Grant Sponsor: Turkish Academy of Sciences (TUBA/GEBIP/EK).en_US
dc.identifier.citationAkkaya, H., Kılıç, E., Eyüboğlu Dinç, S. ve Yılmaz, B. (2014). Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats. Journal of Biochemical and Molecular Toxicology, 28(8), 373-377. https://dx.doi.org/10.1002/jbt.21573
dc.identifier.doi10.1002/jbt.21573
dc.identifier.endpage377
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8
dc.identifier.scopusqualityQ2
dc.identifier.startpage373
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.21573
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2973
dc.identifier.volume28
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHyperhomocysteinemia
dc.subjectMethionine
dc.subjectKisspeptin
dc.subjectApoptosis
dc.subjectOxidative Stress
dc.titlePostacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats
dc.typeArticle

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