Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer

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dc.authorid0000-0003-2715-4002
dc.authorid0000-0002-0443-6966
dc.authorid0000-0002-5823-1704
dc.authorid0000-0002-9815-1848
dc.authorid0000-0001-7934-7039
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorÇakan, Burçin
dc.contributor.authorDemir, Tarık
dc.contributor.authorBilici, Ahmet
dc.contributor.authorÖven, Bala Başak
dc.contributor.authorHamdard, Jamshid
dc.contributor.authorOlmuşçelik, Oktay
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorŞeker, Mesut
dc.contributor.authorYıldız, Özcan
dc.date.accessioned2021-12-16T07:26:19Z
dc.date.available2021-12-16T07:26:19Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization. A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found. The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (<= 196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P P = .023 respectively). Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization.
dc.identifier.citationAçıkgöz, Ö., Çakan, B., Demir, T., Bilici, A., Öven, B. B., Hamdard, J. ... Yıldız, Ö. (2021). Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer. Medicine, 100(44). https://dx.doi.org/10.1097/MD.0000000000027712
dc.identifier.doi10.1097/MD.0000000000027712
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue44
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1097/MD.0000000000027712
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8680
dc.identifier.volume100
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectMetastatic Colorectal Cancer
dc.subjectPlatelet-to-Lymphocyte Ratio
dc.subjectPrognostic Factor
dc.subjectSurvival
dc.subjectTreatment Response
dc.titlePlatelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer
dc.typeArticle

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