Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy

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dc.authorid0000-0003-2312-2521
dc.contributor.authorDikkaya, Funda
dc.contributor.authorSarıcı, Ahmet Murat
dc.contributor.authorErbek, Firuze
dc.contributor.authorCelkan, Tiraje
dc.contributor.authorMangan, Mehmet Serhat
dc.contributor.authorAydın, Övgü
dc.contributor.authorDemirkesen, Cüyan
dc.contributor.authorPazarlı, Halit
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:55Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000428760800023
dc.descriptionPubMed ID: 28058667
dc.description.abstractPurpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucleated for retinoblastoma and to analyze the association between growth pattern, rosetta formation, tumor thickness, presence of necrosis, calcification, neovascularization, rate of mitosis, and high-risk histopathologic factors. Methods Pathology reports of 59 eyes who had received enucleation for retinoblastoma were reviewed retrospectively. The histopathologic data included presence of choroidal invasion, optic nerve invasion, scleral extension, tumor thickness, presence of necrosis, calcification, neovascularization, rosetta formation and lymphocyte infiltration, rate of mitosis, and growth pattern. Results This study included 59 eyes from 30 (50.8%) male and 29 (49.2%) female patients. The mean age was 22.87 +/- 18.99 months. There were 30 (50.8%) eyes with choroidal invasion, 30 (50.8%) eyes with optic nerve invasion, and 5 (8.5%) eyes with scleral invasion. Endophytic growth pattern was seen in 27 (45.8%) eyes, exophytic growth pattern was seen in 2 (3.4%) eyes, and combined growth pattern was seen in 30 (50.8%) eyes. Exophytic growth pattern was found statistically related to choroidal invasion (p = 0.00). Although tumor with greater thickness tended to have more choroidal invasion (p = 0.02), there was no relation between tumor thickness and optic nerve invasion (p = 0.09). Conclusions Incidences of choroidal and optic nerve invasion showed similarity with other developing countries. Because of higher incidence of high-risk factors, intra-arterial chemotherapy with its targeted effect should be preferred carefully.
dc.identifier.citationDikkaya, F., Sarıcı, A., Erbek, F., Celkan, T., Mangan, M., Aydın, Ö. ... Pazarlı, H. (2018). Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy. International Ophthalmology, 38(1), 151-156. https://dx.doi.org/10.1007/s10792-016-0436-8
dc.identifier.doi10.1007/s10792-016-0436-8
dc.identifier.endpage156
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage151
dc.identifier.urihttps://dx.doi.org/10.1007/s10792-016-0436-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2103
dc.identifier.volume38
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectRetinoblastoma
dc.subjectHigh-Risk Histopathologic Factors
dc.subjectChoroidal Invasion
dc.subjectOptic Nerve Invasion
dc.titleEvaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy
dc.typeArticle

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