Evaluation of prognostic factors associated with intensive care unit mortality in patients with hematopoietic stem cell transplantation

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dc.authorid0000-0002-0383-7792
dc.authorid0000-0002-6315-9620
dc.contributor.authorTunay, Burcu
dc.contributor.authorSadri, Sevil
dc.date.accessioned2022-10-20T08:40:44Z
dc.date.available2022-10-20T08:40:44Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground & objective: Although the outcome of patients admitted to ICUs have considerably improved in recent years, hematopoietic stem cell transplantation (HSCT) continues to be significantly associated with mortality.We studied the prognostic factors associated with ICU mortality after HSCT. The Acute Physiological and Chronic Health Evaluation II (APACHE II) was used as a prognostic scoring system.Methods: Within the scope of the research, the clinical and laboratory data of 52 patients who were admitted to the ICU after undergoing HSCT between 2013 and 2019 were analyzed retrospectively.Results: Mortality risk was found to be 4.22 times higher in patients who received mechanical ventilation (MV) within the first 24 h (P = 0.047), 18.37 times higher in patients who received total parenteral nutrition (TPN) support (P = 0.007), and 158.17 times higher in recipients of vasopressor drug support compared to those who did not (P < 0.001). It was found that a one unit increase in GCS score decreased mortality risk by 0.58 fold (P = 0.015). Additionally, a one unit increase in heart rate was found to increase mortality risk by 1.03 fold (P = 0.010). Whereas, one unit increases in systolic blood pressure or diastolic blood pressure decreased the mortality risk by 0.91 and 0.92 fold, respectively (P = 0.001 and P = 0.002). Mortality was not associated with APACHE II or graft-versus-host disease. Conclusion: Receiving MV, TPN or vasopressor treatment, and having lower GCS, higher heart rate, lower systolic and diastolic blood pressure were associated with an increase in the risk of ICU mortality in HSCT recipients admitted to the ICU.
dc.identifier.citationTunay, B. ve Sadri, S. (2022). Evaluation of prognostic factors associated with intensive care unit mortality in patients with hematopoietic stem cell transplantation. Anaesthesia, Pain and Intensive Care, 26(4), 480-487. https://doi.org/10.35975/apic.v26i4.1951
dc.identifier.doi10.35975/apic.v26i4.1951
dc.identifier.endpage487
dc.identifier.issn1607-8322
dc.identifier.issn2220-5799
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85139181235
dc.identifier.scopusqualityQ4
dc.identifier.startpage480
dc.identifier.urihttps://doi.org/10.35975/apic.v26i4.1951
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9856
dc.identifier.volume26
dc.identifier.wos000861049300010en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTunay, Burcu
dc.institutionauthorSadri, Sevil
dc.language.isoen
dc.publisherAnaesthesia, Pain and Intensive Care
dc.relation.ispartofAnaesthesia, Pain and Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectIntensive Care
dc.subjectMortality
dc.subjectMV-mechanical ventilation
dc.titleEvaluation of prognostic factors associated with intensive care unit mortality in patients with hematopoietic stem cell transplantation
dc.typeArticle

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