Neuroprotective effect of intrastriatal caffeic acid phenethyl ester treatment in 6-oh dopamine model of parkinson's disease in rats

Basit Öğe Kaydı
dc.authorid0000-0003-2143-5268
dc.contributor.authorSoner, Burak Cem
dc.contributor.authorAçıkgöz, Eda
dc.contributor.authorİnan, Salim Yalçın
dc.contributor.authorAyla, Şule
dc.contributor.authorŞahin, Ayşe Saide
dc.contributor.authorÖktem, Gülperi
dc.date.accessioned2021-09-23T07:56:34Z
dc.date.available2021-09-23T07:56:34Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractParkinson's disease (PD) is the second most common neurodegenerative disorder, and the main cause of PD is still not known. Until now, no cure for Parkinson's disease is yet in sight. Caffeic acid phenethyl ester (CAPE) is a polyphenolic component of the propolis, which can be derived from honeybee hive propolis. We aimed to determine the effect of intrastriatal CAPE administration as a neuroprotective agent on 6-hydroxydopamine (6-OHDA)-induced PD model. Adult male Wistar rats weighing 280-320 g were used. The PD model was induced with unilateral intrastriatal 6-OHDA injection. Treatment groups received 20 mu mol/5 mu L/4 day and 80 mu mol/5 mu L/4 day CAPE 24 h after 6-OHDA injection. Eight days after 6-OHDA application, behavioral studies (adhesive tape removal test, open-field test, cylinder test, and apomorphine-induced asymmetric rotational behavior) were performed once more to compare the effects of CAPE on behavior tests. Striatal histological verifications, immunohistochemistry, and stereological quantitation were performed. Our results for the first time showed that, besides improving the motor performance, CAPE treatment also prevents 6-OHDA-induced loss of TH-positive neurons. From our results, CAPE may be a promising clinical agent in the treatment of PD.
dc.description.sponsorshipScientific Research Projects Coordination Unit of the University of NEen_US
dc.identifier.citationSoner, B. C., Açıkgöz, E., İnan, S. Y., Ayla, Ş., Şahin, A. S. ve Öktem, G. (2021). Neuroprotective effect of intrastriatal caffeic acid phenethyl ester treatment in 6-oh dopamine model of parkinson's disease in rats. Parkinson's Disease, 2021. https://dx.doi.org/10.1155/2021/5553480
dc.identifier.doi10.1155/2021/5553480
dc.identifier.issn2090-8083
dc.identifier.issn2042-0080
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1155/2021/5553480
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8282
dc.identifier.volume2021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofParkinson's Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject6-OH Dopamine Model
dc.subjectParkinson's Disease in Rats
dc.subjectIntrastriatal Caffeic Acid
dc.titleNeuroprotective effect of intrastriatal caffeic acid phenethyl ester treatment in 6-oh dopamine model of parkinson's disease in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ayla-Sule-2021.pdf
Boyut:
1.94 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu