Irisin immunostaining characteristics of breast and ovarian cancer cells

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dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorÇelik, Önder
dc.contributor.authorAydın, Süleyman
dc.contributor.authorÖzercan, Hanifi
dc.contributor.authorAcet, Mustafa
dc.contributor.authorAydın, Yalçın
dc.contributor.authorArtaş, Gökhan
dc.contributor.authorTürk, Ahmet
dc.contributor.authorYardım, Meltem
dc.contributor.authorOzan, Gonca
dc.contributor.authorYalçın, Mehmet Hanifi
dc.contributor.authorKocaman, Nevin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:05Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000386769600007
dc.descriptionPubMed ID: 27545213
dc.description.abstractTo determine expression pattern of irisin in tissues obtained from human ovarian cancer, breast cancer, and cervix cancer. Tissue samples obtained from subjects with breast cancer, ovarian cancer cervix cancer, simple endometrial hyperplasia, complex atypical endometrial hyperplasia. At least five sections from each subject were immunohistochemically stained with irisin antibody, and H-score method was used to evaluate irisin intensity. Tissues obtained from healthy breast tissues, proliferative phase endometrium adenomyosis and benign ovarian tumors were accepted as control. Irisin activity was not detected in control breast tissues significantly increased irisin staining was detected in invasive lobular, intraductal papillary, invasive ductal, invasive papillary, and mucinous carcinomas compared to control tissues. Also, significantly increased irisin immunoreactivity was detected in both ovarian endometriosis and mucinous carcinomas compared to benign tumors. However irisin staining was not observed at the papillary carcinoma of the ovary while sections obtained from simple and complex atypical endometrial hyperplasia, and cervix carcinoma demonstrated irisin immunoreactivity. Increased irisin immunoreactivity in tissues obtained from breast, ovary, cervix carcinomas, and endometrial hyperplasia suggest critical role of this peptide during carcinogenesis.
dc.identifier.citationKuloğlu, T., Çelik, Ö., Aydın, S., Özercan, H., Acet, M., Aydın, Y. ... Kocaman, N. (2016). Irisin immunostaining characteristics of breast and ovarian cancer cells. Cellular And Molecular Biology, 62(8), 40-44. https://dx.doi.org/10.14715/cmb/2016.62.8.7
dc.identifier.doi10.14715/cmb/2016.62.8.7
dc.identifier.endpage44
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue8
dc.identifier.scopusqualityQ3
dc.identifier.startpage40
dc.identifier.urihttps://dx.doi.org/10.14715/cmb/2016.62.8.7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2142
dc.identifier.volume62
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIrisin
dc.subjectBreast Cancer
dc.subjectOvarian Cancer
dc.subjectCervix Cancer
dc.subjectEndometrial Hyperplasia
dc.titleIrisin immunostaining characteristics of breast and ovarian cancer cells
dc.typeArticle

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