Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model

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dc.authorid0000-0001-7702-2441
dc.authorid0000-0002-6242-3709
dc.contributor.authorEren, Zehra
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorArı, Elif
dc.contributor.authorÇoban, Jale
dc.contributor.authorÇakalağaoğlu, Fulya
dc.contributor.authorÇağlayan, Burak
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorAkdeniz, Tuba
dc.contributor.authorYanıkkaya, Gülderen
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorKantarcı, Gülçin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:54Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000375351200001
dc.descriptionPubMed ID: 26938976
dc.description.abstractBackground: This study aimed at investigating the possible protective effect of erythropoietin beta on experimental diabetic nephropathy (DN) model in rats. Methods: Sprague Dawley rats (n = 32) were allocated into 4 equal groups of 8 each, the control (Group C), diabetes (Group D), erythropoietin beta (Group E), and erythropoietin beta treated DN (Group E + D) groups. Streptozocin (65 mg/kg) was used to induce diabetes in 10-week old rats. Erythropoietin beta was given intraperitoneally at a dose of 500 IU/kg/3 days of a week for 12 weeks. Renal function parameters, intrarenal levels and activities of oxidative stress biomarkers, serum inflammatory parameters and kidney histology were determined. Results: Group E + D had lower mean albumin-to-creatinine ratio (p < 0.001) as well as higher creatinine clearance (p = 0.035) than the diabetic rats (Group D). Intrarenal malondialdehyde levels were significantly lower (p = 0.004); glutathione (GSH) levels (p = 0.003), GSH peroxidase (p = 0.004) and superoxide dismutase (p < 0.005) activities of renal tissue were significantly higher in Group E + D than in Group D. The mean serum levels of interleukin-4 (p < 0.005), interleukin 1 beta (p = 0.012), interferon gamma (p = 0.018) and tumor necrosis factor alpha (p < 0.005) were significantly lower; serum levels of monocyte chemoattractant protein 1 (p = 0.018) was significantly higher in Group E + D when compared to Group D. The mean scores of tubulointerstitial inflammation (p = 0.004), tubular injury (p = 0.013) and interstitial fibrosis (p = 0.003) were also lower in Group E + D when compared to Group D. Conclusion: Our data seem to suggest a potential role of erythropoietin beta for reducing the progression of DN in an experimental rat model. This protective effect is, in part, attributable to the suppression of the inflammatory response and oxidative damage.
dc.identifier.citationEren, Z., Günal, M. Y., Arı, E., Çoban, J., Çakalağaoğlu, F., Çağlayan, B. ... Kantarcı, G. (2016). Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model. Nephron, 132(4), 292-300. https://dx.doi.org/10.1159/000444649
dc.identifier.doi10.1159/000444649
dc.identifier.endpage300
dc.identifier.issn1660-8151
dc.identifier.issn2235-3186
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage292
dc.identifier.urihttps://dx.doi.org/10.1159/000444649
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3485
dc.identifier.volume132
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofNephronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetic Nephropathy
dc.subjectErythropoietin Beta
dc.subjectRat Model
dc.titlePleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model
dc.typeArticle

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