Assessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus

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dc.contributor.authorDinçgez Çakmak, Burcu
dc.contributor.authorDündar, Betül
dc.contributor.authorKetenci Gençer, Fatma
dc.contributor.authorYıldız, Durkadın Elif
dc.contributor.authorBayram, Feyza
dc.contributor.authorÖzgen, Gülten
dc.contributor.authorAydın Boyama, Burcu
dc.date.accessioned2019-12-20T06:43:42Z
dc.date.available2019-12-20T06:43:42Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractPurpose: VAP-1 plays a crucial role in inflammation, oxidative stress and endothelial dysfunction which are main pathophysiologic mechanisms for gestational diabetes. We aimed to determine serum VAP-1 levels, assess its diagnostic value and correlation with clinical parameters in gestational diabetes. Methods: A total of 60 pregnant women with gestational diabetes and 75 healthy pregnant women between 24-28th gestational weeks between January-June 2017 were included. Pregnant women were screened for gestational diabetes by two-step protocol. Demographic, clinical and laboratory parameters of patients were recorded. VAP-1 was measured using an enzyme-linked immunosorbent assay method. Results: Gestational diabetes group had higher fasting and postprandial glucose, HbA1c, neutrophil-to-lymphocyte-ratio, platelet-to-lymphocyte-ratio, plateletcrit and C-reactive protein. Furthermore, VAP-1 levels were higher in gestational diabetes (3.35 +/- 1.52 vs 2.2 +/- 0.74; p < 0.001). VAP-1 levels >2.315 could predict gestational diabetes with a sensitivity of 70% and specificity of 65.3%. VAP-1 was correlated with clinical follow-up parameters such as fasting glucose (r = 0.473, p < 0.001), postprandial glucose (r = 0.416, p < 0.001), HbA1c (r = 0.462, p < 0.001) and inflammatory biomarkers such as platelet-to-lymphocyte-ratio (r = 0.254, p = 0.04), neutrophil-to-lymphocyte-ratio (r = 0.375, p = 0.003) and C-reactive protein (r = 0.306, p = 0.017). Conclusions: Elevated VAP-1 levels in gestational diabetes correlated with clinical follow-up and inflammatory markers may suggest the pathogenetic role of VAP-1 in gestational diabetes. Hence, we think that VAP-1 could be a promising marker for the prediction of gestational diabetes.
dc.identifier.citationDinçgez Çakmak, B., Dündar, B., Ketenci Gencer, F., Yıldız, D. E., Bayram, F. Özgen, G. ve Aydın Boyama, B. (2019). Assessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus. Biomarkers, 24(8), 750-756. https://doi.org/10.1080/1354750X.2019.1684562
dc.identifier.doi10.1080/1354750X.2019.1684562
dc.identifier.endpage756
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue8
dc.identifier.scopusqualityQ2
dc.identifier.startpage750
dc.identifier.urihttps://doi.org/10.1080/1354750X.2019.1684562
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4574
dc.identifier.volume24
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd.
dc.relation.ispartofBiomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEndothelial Dysfunction
dc.subjectGestational Diabetes
dc.subjectMellitus
dc.subjectInflammation
dc.subjectOxidative Stress
dc.subjectVascular Adhesion Protein-1
dc.titleAssessment of relationship between serum vascular adhesion protein-1 (VAP-1) and gestational diabetes mellitus
dc.typeArticle

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