A model based on random walk with restart to predict circRNA-disease associations on heterogeneous network

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dc.authorid0000-0001-6657-9738
dc.contributor.authorVural, Hüseyin
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorAlhajj, Reda
dc.date.accessioned2020-03-05T11:18:29Z
dc.date.available2020-03-05T11:18:29Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractRecent studies show that circRNAs have critical roles in many biological processes. Knowing the associations between circRNAs and diseases may contribute to the understanding of the mechanism of circRNAs and to the diagnostic and therapeutic methods of diseases at the molecular level. A small number of computation models have been developed to estimate CircRNA-disease associations. Therefore, in this study, a computational model has been developed. Similarity matrices have been obtained for circRNA and disease respectively by applying gaussian on the data obtained from the circRNADisease database. Then, random walk with restart algorithm applied on the combined matrices. The AUC value was obtained by 5-fold cross validation is 0.861 and this demonstrates the reliability of the model.
dc.identifier.citationVural, H., Kaya, M. C. ve Alhajj, Reda S. (2019). A model based on random walk with restart to predict circRNA-disease associations on heterogeneous network. IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM) içinde (929-932. ss.). Vancouver, Canada, 27-30 August 2019. http://doi.org/10.1145/3341161.3343514
dc.identifier.doi10.1145/3341161.3343514
dc.identifier.endpage932
dc.identifier.isbn9781450368681
dc.identifier.scopusqualityN/A
dc.identifier.startpage929
dc.identifier.urihttp://doi.org/10.1145/3341161.3343514
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5000
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAssociation for Computing Machinery
dc.relation.ispartofIEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCircRNA-Disease Association
dc.subjectPrediction
dc.subjectRandom Walk
dc.titleA model based on random walk with restart to predict circRNA-disease associations on heterogeneous network
dc.typeConference Object

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