Bölüm "İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı" seçeneğine göre listele
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Öğe Aesthetic evaluation of free gingival graft applied by partial de-epithelialization and free gingival graft applied by conventional method: A randomized controlled clinical study(Springer, 2023) Naziker, Yonca; Ertuğrul, Abdullah SeçkinObjectiveThe aim of this clinical study was to compare the partially de-epithelialized free gingival grafts (d-FGGs) with the conventional free gingival grafts (FGGs) aesthetically using photographic analysis and Visual Analogue Scale (VAS).Materials and methodsA total of 30 defects were treated in 15 patients with attached gingiva insufficiency. In the split-mouth study, d-FGGs were applied on one side (test group), while FGGs were applied on the contralateral side (control group). Results of clinical periodontal parameters were evaluated in 6-month follow-up, and aesthetic evaluation results were evaluated in 1-, 3-, and 6-month follow-ups.ResultsAmong the periodontal clinical parameters examined, only the keratinized tissue (KT) width was found to be statistically significantly higher in the test group compared to the control group. In the photo analysis evaluation, the Delta E value at the 3rd month was statistically significantly higher in the test group. In VAS evaluation, there was no significant difference between the two groups in the time periods examined.ConclusionPhoto analysis is an objective, sensitive, reproducible, and safe method that can be used in dentistry and medicine by detecting the slightest changes and giving more detailed and superior results than visual evaluation. The d-FGG application could provide acceptable aesthetic results by providing an appearance compatible with the gingival contour and gingiva in the adjacent region in creating keratinized gingiva.Öğe Annexin levels in gcf determine the imbalance of periodontal inflammatory regulation(2024) Yılmaz, Melis; Bal, İpek; Hanlı, Sena; Türkmen, Emrah; Balcı, Nur; Uslu Toygar, HilalObjective: Annexin-1 (ANXA1), a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while annexin-2 (ANXA2) is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease. Methods: Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and the periodontal inflamed surface area (PISA) levels were noted. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the ANXA1, ANXA2 and IL-1β levels. Results: Salivary and serum concentrations of ANXA1 was significantly lower in the periodontitis group than in the control group (respectively, p = 0.0177 and p = < 0.0001). Periodontitis patients demonstrated higher serum ANXA2 and IL-1β concentrations compared to controls (respectively, p = 0.0002 and p = 0.0017). As an inflammatory index; saliva, serum and GCF ANXA1/ANXA2 ratio were significantly lower in the periodontitis group compared to healthy controls. Conclusions: The data suggest that periodontitis is associated with a disruption of the balance between pro-inflammatory mechanisms (ANXA2 and IL-1beta) and inflammation resolution (ANXA1), in parallel with PISA levels. Clinical Trial Registration: ClinicalTrials.gov NCT06554756 (15/08/2024).Öğe Bir diş hekimliği fakültesi öğrencilerinin hepatit B, hepatit C, HIV seroprevalanslarının ve hepatit B enfeksiyonu ile ilgili bilgi düzeyi, tutum ve davranışlarının değerlendirilmesi: Kesitsel klinik araştırma(Turkiye Klinikleri, 2022) Çukurova Yılmaz, Zeynep; Altaş, Nurcan; Gözetici Çil, BurcuHepatit B virüsü (HBV) enfeksiyonu, toplumumuzda yaygın olarak görülen ve dental işlemler yoluyla diş hekimlerinden hastalara ya da hastalardan diş hekimlerine bulaşabilen bir viral enfeksiyondur. Bu çalışmada, diş hekimliği fakültesi 4 ve 5. sınıf öğrencilerinin HBV enfeksiyonu ile ilgili bilgi düzeylerinin, bu konudaki tutum ve davranışlarının değerlendirilmesi amaçlandı. Buna ek olarak, yüksek bulaşıcılık oranına sahip HBV, hepatit C virüsü (HCV) ve insan immün yetmezliği virüsü [human immunodeficiency virus (HIV)] seroprevalansları değerlendirildi. Gereç ve Yöntemler: Bu kesitsel klinik araştırmada, gönüllülere demografik bilgiler, HBV hakkındaki bilgi düzeyleri, tutum ölçeği ve davranış ölçeği olmak üzere 4 bölümden oluşan çevrim içi anket uygulandı. Öğrencilerin HBV, HCV ve HIV seroprevalanslarının değerlendirilmesinde ise ELISA testi kullanıldı. Bulgular: 4. Sınıf öğrencilerinin bilgi düzeyi skorları ile tutum puan ortalamaları arasında istatistiksel olarak anlamlı farklılık gözlendi (p=0,0001). Bilgi düzeyi yüksek olan öğrencilerin tutum puanı ortalamaları, bilgi düzeyi orta olan öğrencilerden istatistiksel olarak anlamlı derecede yüksek bulundu (p=0,0001). 4. Sınıf öğrencilerinden bilgi düzeyi düşük olan öğrencilerin davranış puanı ortalamaları, bilgi düzeyi orta ve yüksek olan öğrencilerden istatistiksel olarak anlamlı derecede düşük bulundu (p=0,012, p=0,001). 5. Sınıf öğrencilerinin ise bilgi düzeyi, tutum ve davranış puan ortalamaları arasında istatistiksel olarak anlamlı farklılık gözlenmedi (p=0,156, p=0,574). Sonuç: HBV genel bilgi seviyesi ve serolojik test sonuçları yeterli düzeyde görünse de kliniğe yeni başlayan 4. sınıf öğrencilerinden HBV enfeksiyonu hakkında bilgi düzeyi düşük olanların tutum ve davranışlarının daha yetersiz olduğu görüldü. Bu sonuç, sürekli enfeksiyon kontrolü eğitiminin gerekliliğini vurgulamaktadır.Öğe Clinical comparisons of different fixed orthodontic retainers(Dental Press International, 2022) Güneş, Recep Onur; Sayar, Gülşilay; Toygar, HilalObjective: The aim of this prospective clinical study was to compare the clinical outcomes of three different fixed lingual retainers, in terms of effects on periodontal health and success rate. Methods: Forty five patients aged 13 to 25 years were randomly assigned into three groups, using bonded upper and lower lingual retainers. The study groups were as follows: Group 1-BondA-Braid®, Group 2-everStick® ORTHO, Group 3-Super-Splint. The follow-up appointments were performed two weeks (Baseline=T0), one month (T1), three months (T2), and six months (T3) after the application of retainers. Plaque Index (PI), Gingival Index (GI), Probing Depth (PD), Bleeding in Probing (BOP) and Retainer Failure were assessed at each appointment. Results: The everStick Ortho group showed significantly lower PI values on the upper-lower lingual side after three (p=0.008) and six (p=0.001) months. The everStick Ortho group had significantly lower upper lingual (GI) levels after six months, and lower lingual side levels after one month. The Super-Splint group showed significantly lower PD values on the upper lingual side after six months. The everStick Ortho group presented significantly lower BOP levels after six months on the upper lingual side. No significant differences between the groups (p>0.05) in terms of retainer failure were found. Conclusions: The everStick Ortho group presented better results in terms of periodontal health. The failure rates of the retainers were similar.Öğe Clinical research clinical performance of posterior indirect resin composite restorations with the proximal box elevation technique: A prospective clinical trial up to 3 years(Quintessence Publishing Co, Inc, 2024) Gözetici Çil, Burcu; Öztürk Bozkurt, Funda; Genç Çalışkan, Gencay; Yılmaz, Burcu; Aksaka, Nurcan; Özcan, MutluPurpose: The study evaluated the clinical performance of partial indirect resin composite (PIRC) restorations with "proximal box elevation" (PBE) placed in molars. Materials and Methods: Sixty-three patients received 80 posterior PIRC (SR Nexco, Ivoclar Vivadent) restorations. Large posterior defects with cuspal loss and deep cervical margins were included in the study. PBE was performed prior to preparation and impression making. Two independent observers evaluated the restorations using the FDI criteria (scores 1-5) for esthetic, functional, and biological properties. Patients were recalled at 6 months and 1, 2, and 3 years. Overall success rates were calculated (Kaplan-Meier analysis) and compared (log-rank tests) according to baseline variables. The impact of the baseline variables on the failure of the restorations was analyzed (multiple proportional Cox regression). Results: Seventy-nine (98.7%), 69 (88.4%), 66 (92.9%), 44 (86.2%) and 45 (91.8%) PIRCs completed their follow up at baseline, 6 months, and 1, 2 and 3 years, respectively. In total, 10 failures were observed: 5 with partial loss, 4 with material chipping, and one with secondary caries, yielding an overall success rate of 87.5% and a survival rate of 93.8%, with a mean observation time of 26.5 +/- 13.6 months. Conclusions: PIRCs with PBE demonstrated a high survival rate and satisfactory esthetic properties. Failure was less likely for PIRC restorations with partial cuspal coverage (onlay) compared to full cuspal coverage (overlay).Öğe Comparison of fracture resistance of immature sheep teeth using pozzolan MTA-based sealer(Publishing House Bulgarian Academy of Sciences, 2021) Özükoç, Can; Kanat, Aykut; Moubaraki, Babak; Jahandideh, Aslan; Fadhil, Sadeq Mohammed Taqi; Türkmen, EmrahThe aim of this study was to evaluate the influence of pozzolan sealers used for apexification in immature permanent teeth on the root fragility using a performance simulation in sheep teeth in vitro. The fracture resistance of 125 incisor teeth from 38 domestic sheep was evaluated by filling the root canals with AH Plus, ProRoot MTA, and the Biodentine and Pozzolan MTA-based materials EndoSeal MTA and Endocem MTA after performing immature, permanent tooth simulations. The highest fracture resistance was obtained in a negative control group where no treatment was administered. The lowest resistance was found in a positive control group where no canal filling was performed. A significant difference between these groups was found (p < 0.001). The median fracture value of the AH Plus experimental group (934.14 + 95.38 Newtons (N)) was higher than both the Endocem MTA (893.87 +125.41 N) and the EndoSeal MTA groups (869.08 + 91.49 N). However, the differences between these groups were not statistically significant (p > 0.05). The results of the simulations indicate that the Pozzolan MTA-based EndoSeal MTA and Endocem MTA increase the fracture resistance of immature permanent teeth.Öğe Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs(Springer, 2012) Şimşek, Selen Burçak; Çayır Keleş, Gonca; Barış, Sancar; Özkan Çetinkaya, BurcuThe purpose of this study was to compare the effectiveness of mesenchymal stem cells (MSCs) with platelet-rich plasma (PRP) as scaffold and autogenous cortical bone (ACB) graft with and without PRP in the regenerative treatment of class II furcation defects in dogs. The mandibular second, third, and fourth premolars (P2, P3, P4) and maxillary P3 and P4 of both sides in three dogs were selected for experimentation. Class II furcation defects (5 mm in height and 2 mm in depth) were surgically created. Five weeks after the first operation, scaling + root planning (group 1), PRP (group 2), ACB (group 3), combination of ACB/PRP (group 4), and combination of MSCs/PRP (group 5) treatments were performed during open flap debridement. The percentage of cementum and alveolar bone formation was evaluated by histomorphometric analysis after a healing period of 8 weeks. There was new cementum along with periodontal ligament and coronal growth of alveolar bone in all groups. Cementum formation was significantly higher in groups 3, 4, and 5 compared to the control group (P < 0.05) with no significant difference between groups 2, 3, 4, and 5. Alveolar bone formation was similar in all groups (P > 0.05). It can be concluded that periodontal regeneration with complete filling of class II furcation defects with cementum, alveolar bone, and periodontal ligament is obtained 8 weeks after ACB, ACB/PRP, and MSCs/PRP treatments; however, efficacy of none is higher than another.Öğe Could ofloxacin be an alternative to amoxicillin–Metronidazole as an adjunct to non-surgical periodontal therapy?(AVES, 2023) Alkan, Begüm; Altaş, NurcanObjective: The best antibiotic approach for generalized periodontitis remains under debate. Therefore, in this study, the systemic administration of ofloxacin was compared against amoxi cillin–metronidazolein terms of clinical periodontal parameters. Materials and Methods: A prospective, experimental, double-blind, active-controlled, randomized, parallel-grouped, and single-centered clinical trial was carried out at a university hospital in Istanbul, Turkey, between April 2017 and August 2019. Seventy-four patients with generalized periodontitis were randomized into 2 study groups (ofloxacin and amoxicillin–metronidazole groups). Clinical periodontal parameters were recorded at baseline and at 1-, 3-, and 6-month follow-ups following phase 1 periodontal therapy. Changes in clinical periodontal parameters from baseline to 6 months were evaluated and compared between groups. Results: Thirty-eight patients were lost to follow-up and excluded from the analysis. Thirty-six patients completed the study (ofloxacin group, n = 18; amoxicillin–metronidazolegroup, n = 18). The clinical periodontal parameters were significantly reduced in both groups at all time points compared to baseline (P < .05). No significant differences in plaque or gingival indices were observed between the groups at any time point (P > .05). Bleeding on probing at 1 month as well as probing depth and clinical attachment loss at 6 months were significantly lower in the amoxicillin–met ronidazolegroup compared to the ofloxacin group (P < .05). No adverse effects were reported. Conclusion: Systemic ofloxacin administration as an adjunct to non-surgical periodontal therapy showed significant clinical improvement during the first 3 months but was not as effective as amoxicillin–metronidazole at 6 months.Öğe Dental and periodontal health status of subjects with sickle cell disease(Elsevier, 2011) Güzeldemir, Esra; Uslu Toygar, Hilal; Boğa, Can; Cilasun, ÜlkemBackground/purpose: Sickle cell disease (SCD) is a chronic, hereditary, autosomal recessive disorder. The pathophysiology of SCD is thought to result from polymerization of hemoglobin S in red blood cells under hypoxic conditions, which results in vaso-occlusion. The aim of this study was to determine the periodontal and dental health status of patients with SCD. Materials and methods: Fifty-five SCD patients and 41 healthy individuals were evaluated. Detailed medical and dental histories were taken, and a record made of dental status (missing teeth, restorations, impacted teeth, root canal treatment), periodontal status [plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP)], alveolar bone level (ABL), mandibular cortex index, and bone quality index. Results: Two hundred and six teeth were missing, and a total of 195 teeth had restorations. Between-group differences existed for the PI, GI, and BOP; these variables were higher in patients than in the healthy individuals (P < 0.0001). No between-group differences existed for PD. In patients, there was a positive correlation between PD and BOP (P < 0.0001; r = 0.657), PD and GI (P = 0.02; r = 0.299), PD and PI (P = 0.01; r = 0.343); BOP and GI (P < 0.0001; r = 0.503), BOP and PI (P < 0.0001; r = 0.496); and GI and PI (P = 0.003; r = 0.388). The ABL in patients was found to be similar to that of the general population with an unknown periodontal condition. Conclusion: No clinical periodontal disease or attachment loss was detected in patients. However the PI, GI, and BOP were significantly higher in patients with SCD, which may reflect an as yet undefined variable response to microbes. There were no significant differences, however, in pocket depth between the two groups. Therefore we are unable to confirm any significant relationship between SCD and periodontal diseases. Oral health is not a major concern for SCD patients. The reason for this finding may be the potentially severe complications of SCD, which mean that oral and dental problems are not major concerns for this particular group of patients.Öğe Dental implantların osseointegrasyon sürecinin farklı mobilite ölçüm yöntemleri ve klinik parametreler kullanılarak karşılaştırmalı olarak değerlendirilmesi(İstanbul Medipol Üniversitesi Diş Hekimliği Fakültesi, 2017) Uzunoğlu, Süleyman; Uslu Toygar, HilalDental implantların osseointegrasyon sürecinin farklı mobilite ölçüm yöntemleri ve klinik parametreler kullanılarak karşılaştırmalı olarak değerlendirilmesi. Çalışmamızın amacı; rezonans frekans analizi, elektromekanik yöntem (Periotest) ve bazı klinik parametreler kullanılarak implantların stabilitesine etki eden faktörlerin osseointegrasyon süreci içerisinde değerlendirilmesidir. Çalışmaya; sistemik bir rahatsızlığı bulunmayan, periodontal olarak sağlıklı, belirlenen boy ve çapta implant uygulanabilecek yeterli alıcı kemiğe sahip 28 hasta kabul edilmiştir. Üst çeneye 22, alt çeneye 39 adet olmak üzere toplam 61 adet Bredent SKY® implant yerleştirilmiştir. Uygulanan implantların çapları sırasıyla 3.5, 4.0 ve 4.5 mm, boyları ise; 10 ve 12 mm'dir. Pre-operatif değerlendirme amacıyla panoramik radyografi ve CBCT kullanılmıştır. Kemik yoğunluğu değerlendirmesi için CBCT'de elde edilen PU değerleri kaydedilmiştir. Bu değerler; operasyon esnasında, 1.hafta, 4.hafta ve 12.haftalarda yapılan stabilite ölçümleriyle (Osstell ISQ-Periotest) karşılaştırılmıştır. Aynı zamanda yapışık dişeti genişliği, sondlamada kanama, cep derinliği, dişeti kalınlığı ve krestal kemik rezorbsiyonu gibi periodontal parametrelerin değerlendirilmesi yapılmıştır. Sonuçlara bakıldığında; Osstell ISQ ve Periotest tüm ölçüm zamanlarında benzer yanıtlar vermiştir. Alt çeneye yerleştirilen implantların ISQ değerleri tüm ölçüm zamanlarında üst çene ISQ değerlerinden yüksek, PTV değerleri de tüm zamanlarda alt çenede daha düşük görülse de çeneler arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. Osstell ISQ ve Periotest cihazlarıyla yapılan tüm ölçüm zamanları arasında istatistiksel olarak anlamlı bir fark görülmüş, en düşük ortalama ISQ ve en yüksek ortalama PTV değeri 4.haftada elde edilmiştir. PU değerleri ile başlangıç ve 12.hafta ISQ değerleri arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur. Ancak PU değerleri ile PTV değerleri arasında ilişki saptanmamıştır. İmplantların stabiliteleri çaplara göre değerlendirildiğinde; ISQ değerlerinde 3.5 mm çapındaki implantlar ile 4.0 ve 4.5 mm çapındaki implantlar arasında istatistiksel olarak anlamlı bir fark tespit edilmiştir. İmplantların stabiliteleri boylara göre değerlendirildiğinde; her iki ölçüm yönteminde de 10 mm ve 12 mm boyundaki implantlar arasında anlamlı bir fark bulunmamıştır. Çevresinde 2 mm'nin altında yapışık dişeti bulunan grupta sadece sondlamada kanama ortalamaları anlamlı düzeyde yüksek tespit edilmiştir.Öğe Dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDSCs), and periodontal ligament stem cells (PDLSCs) isolation, characterization and the effectiveness of allantoin as bioactive molecule for dental regeneration(2025) Mutlu Özçınar, Betül; Özükoç, Can; Türkmen, Emrah; Çakır, RabiaIntroduction: Dental stem cells are valuable tools in regenerative medicine due to their pluripotency and self-renewal properties. This study aimed to investigate the effects of allantoin (Al) on Dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDSCs), and periodontal ligament stem cells (PDLSCs) regarding cytotoxicity, proliferation, wound healing, and osteogenic differentiation. Methods: Human dental stem cells were isolated from three dental tissues using the explant culture method and cultured in DMEM-F12 medium supplemented with 15 % fetal bovine serum (FBS) and antibiotics. The cytotoxicity and proliferation of allantoin were assessed using the XTT cell viability assay at concentrations ranging from 0.25 to 5 mg/mL. Wound healing was evaluated through a scratch assay at 1 mg/mL, and osteogenic differentiation was assessed using Alizarin Red S staining at 0.5 mg/mL and 1 mg/mL. Results: Al exhibited no cytotoxic effects across the tested concentrations. It enhanced cell proliferation, particularly in SHEDSCs at 5 mg/mL. DPSCs also showed significant improvement in wound healing in the scratch assay. At 1 mg/mL, Al inhibited osteogenic differentiation in DPSCs and PDLSCs, as indicated by reduced mineralization. Conclusion: Al shows potential as a non-cytotoxic agent for enhancing the proliferation of dental stem cells, especially SHEDSCs. However, its limited effect on wound healing of SHEDSCs and PDLSCs and inhibition of osteogenic differentiation at higher concentrations suggest that further optimization is required for its application in bone regeneration. Statement of Clinical Relevance: Evaluation of the effects of plant-based therapeutic compounds on various types of dental stem cells may have the potential to increase the success of stem cell-based therapies in clinical applications in regenerative dentistry.Öğe Dental students' and dental school graduates' practical skills: An international survey of perceptions of national dental associations in europe(Quintessence Publishing Co Ing, 2024) Wolf, Thomas Gerhard; Dianiskova, Simone; Cavalle, Edoardo; Aliyeva, Rena; Cagetti, Maria-Grazia; Campus, Guglielmo; Deschner, James; Forna, Norina; İlhan, Duygu; Saag, MarePurpose: Dental students learn knowledge and practical skills to provide oral health care to the population. Practical skills must be maintained or continuously developed throughout a professional career. This cross-sectional survey aimed to evaluate the perception of practical skills of dental students and dental-school graduates by national dental associations (NDAs) in Materials and Methods: A questionnaire of 14 items collected information on pre-/postgraduate areas. Results: A total of 25 countries participated (response rate: 69.4%), with 80.0% having minimum requirements for practical skills acquisition and 64.0% starting practical training in the 3rd year of study. In countries where clinical practical work on patients begins in the 2nd year of study, practical skills of graduates are perceived as average, starting in the 3rd year of study as mainly good, starting in the 4th as varying widely from poor to very good. In total, 76.0% of respondents feel that improvements are needed before entering dental practice. Improvements could be reached by treating more patients in dental school (32.0%), increasing the quantity of clinical training (20.0%), or having more clinical instructors (12.0%). In 56.0% of the countries, it is possible to open one's own dental practice immediately after graduation, and in 16.0%, prior vocational training is mandatory. Conclusions: All participating countries in the ERO-FDI zone reported practical training in dental school, most starting in the 3rd year of study. The perception of practical skills of dental students and dental-school graduates among NDAs is very heterogeneous. Reasons for the perceived deficiencies should be further explored.Öğe Does anxiety have an impact on temporomandibular disorders? A study in a Turkish sample by using specific questionnaires(2024) Akbulut, Aslıhan; Kurt, Hanefi; Uslu Toygar, Hilal; Yıldırım, ErolObjective: The aim of the study is to verify the impact of anxiety on temporomandibular disorders (TMD) by using specific questionnaires in a Turkish sample. Methods: This survey was conducted on 292 patients with a mean age of 38.59 ± 10.38 using Helkimo index, Oral Health Impact Profile (OHIP-14), and State Trait Anxiety Inventory (STAI). Spearman Correlation and Fisher Freeman Halton analyses were used for the statistical analysis. Results: There was no statistically significant difference between the Helkimo anamnestic dysfunction (HAD) levels in terms of OHIP-14 total scores or STAI state scores. There was, however, a statistically positive correlation between STAI state and OHIP-14 total values at 18.4%, a positive correlation between the STAI trait and OHIP-14 total values at 29.8%. Conclusion: No significant correlation was observed between OHIP-14 total scores, STAI state scores, and HAD levels. Therefore, this study did not find a significant relationship between TMDs and anxiety.Öğe Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study(John Wiley and Sons Inc, 2023) Önder, Canan; Akdoğan, Nihan; Kurgan, Şivge; Balcı, Nur; Serdar, Ceyhan Ceran; Ceran Serdar, Ceyhan; Serdar, Muhittin Abdulkadir; Günhan, MeralObjectivesThe aim of this study was to identify the effects of smoking and periodontal inflammation on tryptophan-kynurenine metabolism as well as the correlation between these findings and clinical periodontal parameters. BackgroundIt has been shown that the tryptophan amino acid's primary catabolic pathway, the kynurenine pathway (KP), may serve as a key biomarker for periodontal disease. Although there are studies investigating the effect of smoking on KYN-TRP metabolism, the effect of smoking on periodontal disease through KP has not been revealed so far. MethodsThe salivary and serum samples were gathered from 24 nonsmoker (NS-P) stage III, grade B generalized periodontitis and 22 smoker (S-P) stage III, grade C generalized periodontitis patients, in addition to 24 nonsmoker (NS-C) and 24 smoker (S-C) periodontally healthy control individuals. Saliva and serum IL-6, kynurenine (KYN), and tryptophan (TRP) values, and KYN/TRP ratio were analyzed by liquid chromatography-mass spectrometry. Clinical periodontal measurements were recorded. ResultsSalivary TRP values were significantly higher in both periodontitis groups than control groups (p < .05). Salivary KYN values were highest in NS-P group (p < .05). Salivary KYN values did not differ significantly between periodontitis groups (p = .84). Salivary KYN/TRP ratio was significantly lower in NS-P group compared to other groups (p < .001). Serum TRP value is higher in S-P group than other groups; however, significant difference was found in S-C group (p < .05). Serum KYN values were significantly lower in smokers than nonsmokers. Serum KYN/TRP ratio is higher in NS-P group. NS-P group has the highest salivary IL-6 levels, NS-C group has the lowest values (p < .05). ConclusionsOur results point out that smoking exacerbates inflammation in the periodontium and increases TRP destruction and decreases IDO activity by suppressing KP in serum. As a result, kynurenine and its metabolites may be significant biomarkers in the link between smoking and periodontal disease.Öğe Effect of non-surgical periodontal treatment on lipoxin A4 levels in periodontitis patients(Academic Publishing House, 2022) Türkmen, Emrah; Gökmenoğlu, Ceren; Kara, Cankat; Öngöz Dede, Figen; Erbak Yılmaz, Huriye; Çanakçı, VarolThe aim of this study was to determine the lipoxin A4 (LXA4) in gingival crevicular fluid (GCF) and saliva in chronic periodontitis (CP) patients before and after non-surgical periodontal treatment (NSPT). A total of twenty subjects, ten patients with CP and ten healthy individuals were included in this study. Clinical measurements, GCF and saliva samples were obtained at the beginning and one month after NSPT. GCF and salivary LXA4 were investigated by ELISA. Salivary LXA4 were significantly higher in CP than in healthy subjects (p [removed] 0.05). GCF LXA4 were lower in CP and decreased after NSPT, but these differences were not significant (p > 0.05). However, GCF LXA4 in post-treatment CP group were significantly lower than in healthy subjects (p < 0.05). Negative correlation was found between probing depth and GCF LXA4 in CP group (r = ?0.717; p < 0.05). Within the limitations of this study, LXA4 might have a potential role in both the pathogenesis of periodontitis and the healing process.Öğe Effect of repolishing on the surface roughness and color stability of air-abraded resin composites(2022) Altaş, Nurcan; Aydınoğlu, Aysu; Gözetici Çil, Burcu; Keleşoğlu, Ergün; Sağır, Kadir; Hazar Yoruç, Afife BinnazAim: Air powder polishing (APP) can cause roughness on composite surfaces, and consequently the color change that occurs over time affects the aesthetic negatively. Here, we aim to investigate the effect of repolishing on the roughness and discoloration of resin composites after APP to avoid its negative effects for the first time. Methodology: A total of 39 composite discs were randomly allocated into three groups: Group I: Control (n = 13), Group II: Air Powder Polished (n = 13), and Group III: Air Powder Polished + Re-polished (n = 13). Color and surface roughness of the discs were measured before and after immersion in coffee for 1 week. Color was measured using a colorimeter (CR-400, Konica Minolta, Osaka, Japan), and roughness was measured using a surface roughness analyzer (SJ-400, Mitutoyo, Japan). Results: All specimens in the groups, except those in Group III, showed significant changes in roughness, and all materials showed significant color changes after immersion in the coffee relative to the baseline. There was no statistically significant difference between the groups in terms of roughness and color. Conclusion: In this study, we showed that repolishing after APP does not significantly improve the color stability and roughness of the composite restorations.Öğe Effects of amoxicillin on gingival biopsies and oral smears: A cross-sectional study(Wolters Kluwer Medknow Publications, 2021) Alkan, Begüm; Köroğlu, PınarBackground: Antibiotic use in research volunteers partaking in dental studies varies widely, as inclusion and exclusion criteria used in participant selection lack strict rules. Aim: We aimed to investigate the most appropriate ending time of amoxicillin therapy in healthy subjects before their recruitment and participation in oral histology trials. A cross-sectional design study was conducted in Istanbul, Turkey, between October 2018 and June 2019. Subjects and Methods: Study participants who had undergone a previous course of amoxicillin were divided into three groups according to the amount of time since their last antibiotic dose: group I, within 1 month; group II, within 4-6 months; and group III, within 7-12 months. Periodontal parameters were measured, and smear samples were obtained from buccal mucosa and keratinized gingiva. Gingival biopsies were taken from the upper premolars. Genetic damage and histopathological damage were analyzed with Feulgen reaction and with hematoxylin-eosin staining. Data were analyzed using the Mann-Whitney U, Kruskal-Wallis, and the Pearson Chi-square tests. Results: There were no significant differences in the periodontal parameters and sociodemographic characteristics between the groups (P > 0.05). Higher genetic and histopathological damage scores were observed in group I, which were significantly different compared to the other groups (P < 0.05). No significant differences were observed between groups II and III (P > 0.05). Conclusions: When selecting healthy participants for oral histology trials, at least 3 months should pass after the final dose of amoxicillin is taken to avoid negative effects on gingival tissue and smear samples.Öğe Effects of exercise on periodontal parameters in obese women(NLM (Medline), 2020) Alkan, Begüm; Güzeldemir Akçakanat, Esra; Odabaş Özgür, Bahar; Özgür, T.; Demirdizen Taşkıran, Ayla; Kır, Hale Maral; Alpay, Numan; Çaycı Akkan, EceBackground: Several studies have demonstrated an association between obesity, periodontitis, and exercise. Aims: This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). The study sample comprised of 15 patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Subjects and Methods: Med Calc was used for statistical analysis. Results: After exercise, a significant decrease in BMI and a significant increase in VO2max were observed in both groups. A significant decrease in probing depth and clinical attachment loss, serum leptin, GCF tumor necrosis factor-?(TNF-?) and leptin, and a significant increase in GCF resistin were observed in the CP group. A significant decrease in serum TNF-? and leptin levels and a significant increase in serum resistin and GCF TNF-?, leptin, resistin, and adiponectin levels were observed in the NP group. Significant correlations between bleeding on probing and levels of interleukin-1? and leptin in GCF were observed in the CP group. Conclusions: This study showed that regular exercise exerts different impacts with respect to clinical and biochemical aspects of periodontal and systemic conditions in obese women.Öğe Evaluation of adipokine levels in obese women with periodontitis: A cohort study(Mosher and Linder, Inc, 2021) Alkan, Begüm; Güzeldemir Akçakanat, EsraPurpose: To evaluate the inflammation-related adipokine levels in the body fluids of obese female participants with and without periodontitis using healthy participants as a control group. Methods: A cohort design study was carried out at Kocaeli University between December 2014 and June 2015. The study sample comprised 25 obese female participants with periodontitis (Group 1), 31 obese female participants without periodontitis (Group 2), and 15 lean female participants with healthy periodontium (Group 3), from whom body mass index, clinical periodontal parameters were measured, and serum, saliva, and gingival crevicular fluid (GCF) samples were collected. The three groups' periodontal parameters and adipokine levels were evaluated and compared, and the primary outcome was the difference in local and systemic adipokine levels between the study groups. Results: In the participants' serum samples, tumor necrosis factor-alpha (TNF-alpha) and leptin levels were lower, whereas adiponectin levels were significantly higher in Group 3 than in the obese groups (P<0.05). In the participants' saliva samples, interleukin-1 beta, TNF-alpha, and resistin levels were lowest in Group 3, but adiponectin was lowest in Group 2 (P< 0.05). In the participants' GCF samples, interleukin-113, resistin, and adiponectin levels were higher in Group 1 (P< 0.05). This study showed that the amounts of the adipokines could differ in serum, saliva, and GCF samples from obese female participants with and without periodontitis and from lean female participants with healthy periodontium. CLINICAL SIGNIFICANCE: Periodontal diseases in different severities can affect overall health by altering the amounts of adipokines (IL-1 beta, TNF-alpha, leptin, resistin, and adiponectin) in serum, saliva, and GCF of obese female patients. Clinicians should be aware that periodontal disease can alter inflammatory adipokine levels and may affect other treatment outcomes in obese female patients.Öğe Evaluation of the working posture and upper extremity musculoskeletal complaints among dentistry students(Cetus Publishing, 2022) Altaş, Nurcan; Çukurova Yılmaz, Zeynep; Uzun, Erdem VeliObjective: The prevalence of musculoskeletal disorders (MSDs) among dentists is high and adversely affects the quality of life. In this study, we aimed to evaluate musculoskeletal complaints, working postures, and the risk of MSDs among dentistry students across different departments. Methods: 180 dentistry students were divided into six groups according to their departments. For evaluation of the musculoskeletal complaints, we used the standardized Nordic musculoskeletal disorders questionnaire. The working postures and the potentiality of MSDs were evaluated using the ‘Rapid Upper Limb Assessment’ (RULA). Results: We found that 92.8% of the students had musculoskeletal pain during the last 12 months, and the highest prevalence of symptoms was reported for the neck (68.3%) and the upper back (62.2%). The mean RULA score of the students was 5.02 ± 1.31, indicating a high risk of MSDs. The highest RULA mean score was in the pedodontics group. Conclusion: Our study found a high prevalence of musculoskeletal complaints and high RULA scores among all the dentistry students. Therefore, ergonomic solutions should be developed to regulate their working postures according to the relevant department to prevent future disorders and if necessary, students should encourage to seek professional medical help.
