Bölüm "İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı" seçeneğine göre listele
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Öğe Alteration of exon definition causes amelogenesis imperfecta(SAGE Publications Inc., 2020) Kim, Young-jae; Kang, Jenny; Seymen, Figen; Koruyucu, Mine; Zhang, Hong; Kasımo?lu, Yelda; Bayram, Merve; Tuna-İnce, Elif Bahar; Bayrak, Şule; Tüloğlu, Nuray; Hu, Jan C.; Simmer, James P.; Kim, Jung-WookAmelogenesis imperfecta (AI) is a collection of genetic disorders affecting the quality and/or quantity of tooth enamel. More than 20 genes are, so far, known to be responsible for this condition. In this study, we recruited 3 Turkish families with hypomaturation AI. Whole-exome sequence analyses identified disease-causing mutations in each proband, and these mutations cosegregated with the AI phenotype in all recruited members of each family. The AI-causing mutations in family 1 were a novel AMELX mutation [NM_182680.1:c.143T>C, p.(Leu48Ser)] in the proband and a novel homozygous MMP20 mutation [NM_004771.3:c.616G>A, p.(Asp206Asn)] in the mother of the proband. Previously reported compound heterozygous MMP20 mutations [NM_004771.3:c.103A>C, p.(Arg35=) and c.389C>T, p.(Thr130Ile)] caused the AI in family 2 and family 3. Minigene splicing analyses revealed that the AMELX missense mutation increased exonic definition of exon 4 and the MMP20 synonymous mutation decreased exonic definition of exon 1. These mutations would trigger an alteration of exon usage during RNA splicing, causing the enamel malformations. These results broaden our understanding of molecular genetic pathology of tooth enamel formation.Öğe Aquaporin 5 interacts with fluoride and possibly protects against caries(Public Library of Science, 2015) Anjomshoaa, Ida; Briseno-Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernardo; Mereb, Juan; Leite, Aline; Barreta, Priscila; Silva, Thelma; Dizak, Piper; Ruff, Timothy; Patır, Aslı; Koruyucu, Mine; Abbasoğlu, Zerrin; Casado, Priscila; Brown, Andrew; Zaky, Samer; Bayram, Merve; Kuechler, Erika; Cooper, Margaret; Liu, Kai; Marazita, Mary; Tanboğa, İlknur; Granjeiro, Jose; Seymen, Figen; Castilla, Eduardo; Orioli, Ieda; Sfeir, Charles; Owyang, Hongjiao; Buzalaf, Marilia; Vieira, AlexandreAquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interacts with fluoride.Öğe Assessment of dehiscence and fenestration in children and adolescents using cone beam computed tomography(University Library System, University of Pittsburgh, 2021) Akbulut, Aslıhan; Ballı Akgöl, Beyza; Orhan, Kaan; Bayram, MerveObjective: To define the prevalence of dehiscence and fenestration and classify them in terms of the localization of fenestrations in a random sampled group of children and adolescent patients using cone-beam computed tomography (CBCT). Methods: CBCT performed at the Department of Oral and Maxillofacial Radiology of patients referred by the paediatric dentistry clinic were included in this retrospective study. Image evaluations were performed by dentomaxillofacial radiologist (AA, asst. prof.), and these images were examined in three dimensions of the axial, coronal, and sagittal planes. Intraexaminer agreement for the evaluations were found acceptable. The presence/absence of dehiscence and/or fenestration, fenestration's classification type, and localization of defects were recorded. Moreover, the presence/absence of periapical lesion in related root with dehiscence and fenestration was noted. For statistical analysis, The Chi-Square test, Fisher Freeman Halton Test, and Yates' Continuity of Correction were used. Results: 3061 roots in 1801 teeth of 120 cases were analyzed. The mean age was 9.97±2.22 years. Dehiscence was detected in 261(8.5%) roots of 161(8.9%) teeth, and fenestration was detected 63(2%) roots of 36(2%) teeth. The most common fenestration type was Type I, followed by Type II and IV. Dehiscence was observed more frequently in primary teeth than permanent teeth, and the difference was statistically significant (p:0.000). Dehiscence and fenestration incidence in maxillary teeth was significantly higher than in the mandibular teeth (pdehiscence:0.000, pfenestration:0.004). Apical lesions were observed more in primary teeth than permanent teeth for both defects. Conclusion: This study concludes that alveolar dehiscence and fenestrations are more common in primary teeth than permanent teeth. Moreover, these defects were detected more for the teeth in the maxilla. Concerning endodontic and orthodontic therapies in maxilla, use of CBCT is useful in determining the region's anatomical structure accurately in suspected cases of child and adolescent patients.Öğe Assessment of the feelings and attitudes of children towards their dentist and their association with oral health(Hindawi Publishing Corporation, 2014) Patır Münevveroğlu, Aslı; Ballı Akgöl, Beyza; Erol, TuğbaThis study assessed the feelings and attitudes of children toward their dentists and their association with oral health. Methods. A questionnaire designed to evaluate the attitudes of children toward dentists and preferences was completed by 200 children and their families. In addition, the children were examined and the World Health Organization (WHO) method was used to obtain dmft and DMFT scores. Results. The mean dmft and DMFT scores were 3.52 ± 2.44 and 1.35 ± 1.29, respectively. Of the children, 92.5% reported that they had visited a dentist before. Of the children who had visited dentists, approximately 71.5% reported that they enjoyed their visits. Of the children, 84% preferred female dentists, 76.5% preferred dentists that wore a colored coat, and 63% preferred a decorated dental clinic over a plain clinic. The mean dmft and DMFT values of children who were afraid of dentists were significantly higher than those of children who were not (P<0.01 and P<0.05, resp.). Conclusion. Children have strong perceptions and preferences regarding the appearance of their dentists and dental clinics. The results of this study might help dentists to improve their delivery of care.Öğe Bir grup çocuk ve ergen hastada konik ışınlı bilgisayarlı tomografi isteme nedenleri: Retrospektif çalışma(Türkiye Klinikleri Yayınevi, 2022) Ballı Akgöl, Beyza; Akbulut, AslıhanAmaç: Bu çalışmanın amacı, İstanbul Medipol Üniversitesi Diş Hekimliği Fakültesi Çocuk Diş Hekimliği ABD’ye başvuran çocuk ve ergen hastalarda teşhis ve tedavi amacıyla istek yapılmış konik ışınlı bilgisayarlı tomografilerin (KIBT) kullanım alanlarının retrospektif ola rak incelenmesidir. Gereç ve Yöntemler: Çalışmaya Temmuz 2011- Ocak 2020 tarihleri arasında muayene edilen, teşhis ve tedavi planlaması için KIBT görüntüleri alınmış olan 6-17 yaş arasındaki sis temik olarak sağlıklı hastalar dâhil edilmiştir. KIBT görüntüleri ağız diş ve çene radyolojisi uzmanı tarafından aksiyel, koronal ve sagittal düzlemde 3 boyutlu olarak incelenmiştir. Hastaların yaş, cinsiyet, sis temik durumları ve KIBT isteme nedenleri kaydedilmiştir. Bulgular: Yaşları 6-17 arasında (ortalama 10,45±2,65) değişen, 106’sı (%56,1) erkek, 83’ü (%43,9) kız olmak üzere toplam 189 çocuğun KIBT gö rüntüleri incelenmiştir. En sık KIBT istenme nedeni süpernümerer diş lerin (%37,2) ve sürme gecikmelerinin (%35,9) değerlendirilmesidir. Çocuk diş hekimliğinde; KIBT’ye kist, süpernümerer diş, sürme ge cikmesi, odontoma, kondense osteit, travma, ankiloz, endodontik cer rahi gibi karmaşık tedavi gerektiren olgularda, doğru teşhis ve tedavi planlaması için başvurulmaktadır. Sonuç: Büyüme ve gelişimi devam eden çocuk hastalarda, yüksek radyoduyarlılıkları nedeniyle teşhis ve tedavi planlamasında yalnızca gerekli olduğu durumlarda KIBT’lere başvurulmalıdır.Öğe Candidate gene studies in hypodontia suggest role for FGF3(2013) Vieira, Alexandre Rezende; D'Souza, Rena; Mues, Gabriele; Deeley, Kathleen; Hsin, Hongyuan; Küchler, Erika Calvano; Meira, Raquel; Patır, Aslı; Tannure, Patrícia Nivoloni; Lips, Andrea; Meneghim, Marcelo de Castro; Granjeiro, José Mauro; Seymen, Figen; Modesto, AdrianaIntroduction The majority of tooth agenesis cases are mild (hypodontia) and typically not associated with the gene mutations linked to oligodontia. From this, we hypothesise that most cases of tooth agenesis fit a polygenic mode of inheritance, where several genes with small effects cause a variety of varying phenotypes. Materials and methods In this study, we looked at 18 not typically studied genes in this condition, to ascertain their contribution to hypodontia. Our study subjects consisted of 167 patients with hypodontia and their parents from two cohorts (one from Brazil and one from Turkey). An additional 465 DNA samples (93 cases with hypodontia and 372 controls without family history for tooth agenesis or oral clefts) from Brazil were also available for this study. Ninety-three single nucleotide polymorphisms that maximally represent the linkage disequilibrium structure of the genes for the 18 genes were selected and genotyped using Taqman chemistry. Chi square was used to test if genotype distributions were in Hardy–Weinberg equilibrium, and 24 markers that were in Hardy–Weinberg equilibrium and had allele frequencies higher than 5 % in a panel of 50 CEPH samples were further tested. Association between hypodontia and genetic variants was tested with the transmission disequilibrium test within the programme Family-Based Association Test (FBAT) and by using Chi square and Fisher’s exact tests. Alpha at a level of 0.05 was used to report results.Öğe Characterizing infraocclusion in primary molars: prevalence, accompanying findings, and infraocclusion severity and treatment implications(2024) Ballı Akgöl, Beyza; Üstün, Nilüfer; Bayram, MerveBackground: This manuscript investigates the prevalence, classification, accompanying findings, and treatment modalities associated with infraoccluded primary molars. The aim of this study categorizing primary molars based on the severity of infraocclusion and assessing their respective treatment interventions across different severity groups. Methods: The classification, treatment types, accompanying findings, and the condition of succeeding premolars of infraoccluded molars were documented. Chi-square tests, including Fisher’s Exact Chi-square test, Fisher Freeman Halton Exact Chi-square test, and One Sample Chi-square test, were conducted. The predetermined significance level was less than 0.05. Results: The study population consisted of 3132 subjects aged 3 to 15 years, with a prevalence of 4.3% for infraocclusion. Infraocclusion typically manifests between 6 and 9 years of age and predominantly affects mandibular primary molars. Treatment interventions varied based on infraocclusion severity, with more invasive procedures required for severe cases. Accompanying findings associated with infraocclusion include adjacent teeth tipping, significant deviation in midline shifts towards the affected side and increased caries. Additionally, succeeding premolar agenesis was observed in 2% of infraoccluded molars, with extraction rates higher in cases where the successor tooth was mesially or distally located. Conclusions: The study offers novel insights to dental practitioners concerning the severity and distribution of treatment interventions for infraocclusion. It suggests that more severe cases may necessitate more invasive procedures, with the aim of enhancing patient outcomes through timely intervention and personalized therapeutic strategies.Öğe Children's dental treatment requirements of first permanent molars with poor prognosis(Springer Heidelberg, 2022) Gürcan, Aliye Tuğçe; Bayram, MerveObjectives This retrospective study aimed to (i) survey the correlation between decayed, missing, filled teeth (DMFT), and presence of first permanent molars (FPMs) with poor prognosis and (ii) evaluate the treatment requirements. Materials and methods Seven hundred seventy-three children with fully erupted FPMs were included in this study. DMFT for the permanent dentition, FPMs, and Global DMFT were evaluated based on clinical and radiographic evaluation. The ratio of deep dentin caries (DDC) and apical lesion presence among FPMs, including treatment requirements, were analysed. Spearman rank correlation coefficient and t tests were used for statistical analysis. Results The caries prevalence was found at 61.4%, where the mean DMFT was calculated as 1.89 +/- 2.15. There was a positive correlation between DMFT values and age (r(s) = 0.27). On the other hand, there was a negative correlation between global DMFT values and age (r(s) = - 0.29). Regarding treatment needs of FPM with poor prognosis, 12.03% of the teeth needed pulpectomy, 8.93% pulpotomy, 8.93% pulp capping, and 5.3% extraction. Having higher DMFT values was correlated significantly (p < 0.01) with the presence of DDC (r(s) = 0.50) and apical lesion (r(s) = 0.34). Susceptibility to DDC and apical lesions was significantly higher at mandible than maxilla (p < 0.01). The correlation was significant between DMFT values and apical lesion presence (p < 0.01). Conclusion The ratio of FPMs with poor prognosis was found high in the study group. Treatment requirements of FPMs increased with age, and pulp interventions often took part in the majority. This study successfully concluded that higher DMFT values were correlated with the presence of DDC and apical lesion.Öğe Clinical and oral findings of a patient with Simpson-Golabi-Behmel syndrome(Springer, 2015) Bayram, Merve; Yıldırım, Mine; Seymen, FigenBackground The Simpson-Golabi-Behmel syndrome (SGBS) is an overgrowth condition characterised by macrosomia, mental deficiency, large head, prominent skull sutures, midface deficiency, hypertelorism, broad nose, wide mouth, macroglossia, malocclusion, highly arched palate, and musculoskeletal and limb abnormalities. The aim of this case report is to present clinical and oral findings of an 8-year-old boy who had been diagnosed with SGBS. Case report This patient had supernumerary nipples on the right side, cubitus valgus webbed fingers, scoliosis, umbilical hernia, a coarse face, macrocephaly, hypertelorism, a short broad nose, a wide mouth, a straight facial profile and hearing loss. The patient also had macroglossia, diastemas, over-retained primary tooth, absent mandibular permanent central incisors, and highly arched palate. Lateral cephalometric analysis revealed a large anterior cranial base, a large maxilla and mandible, a large inferior face height, and skeletal Class III jaw relationship. Follow-up After extraction of the over-retained primary central tooth, a partial prosthesis was fabricated in order to maintain function. The patient has been recalled regularly at 6-month intervals for 2 years. Over the following years the prosthesis was replaced due to facial growth. Conclusion Long term follow-up is essential for the patient with SGBS. Preventive dental care, including oral hygiene instructions, diet counselling and the use of fluoride has been implemented.Öğe Comparison of fracture resistance of immature sheep teeth using pozzolan MTA-based sealer(Publishing House Bulgarian Academy of Sciences, 2021) Özükoç, Can; Kanat, Aykut; Moubaraki, Babak; Jahandideh, Aslan; Fadhil, Sadeq Mohammed Taqi; Türkmen, EmrahThe aim of this study was to evaluate the influence of pozzolan sealers used for apexification in immature permanent teeth on the root fragility using a performance simulation in sheep teeth in vitro. The fracture resistance of 125 incisor teeth from 38 domestic sheep was evaluated by filling the root canals with AH Plus, ProRoot MTA, and the Biodentine and Pozzolan MTA-based materials EndoSeal MTA and Endocem MTA after performing immature, permanent tooth simulations. The highest fracture resistance was obtained in a negative control group where no treatment was administered. The lowest resistance was found in a positive control group where no canal filling was performed. A significant difference between these groups was found (p < 0.001). The median fracture value of the AH Plus experimental group (934.14 + 95.38 Newtons (N)) was higher than both the Endocem MTA (893.87 +125.41 N) and the EndoSeal MTA groups (869.08 + 91.49 N). However, the differences between these groups were not statistically significant (p > 0.05). The results of the simulations indicate that the Pozzolan MTA-based EndoSeal MTA and Endocem MTA increase the fracture resistance of immature permanent teeth.Öğe Comparison of root canal length measurement methods in primary teeth(University Library System, University of Pittsburgh, 2018) Koruyucu, Mine; Bayram, Merve; Kasımo?lu, Yelda; Seymen, FigenObjectves: The purpose of this study was to evaluate the accuracy of conven5onal radiography, intraoral digital radi- ovisiography and electronic apex locator in determining the working length of root canals in primary teeth (in-vivo) and to compare the results with scanning electron microscopy measurements (ex-vivo). Materials and Methods: This study was conducted on 50 primary molar teeth. Standard endodon7c access cavity prepara7ons were prepared and the actual length was calculated by calibrated inves3gators. Working lengths were determined by using conven5onal radiography, RVG and apex locator in a total of 116 root canals. A;er the extraconal radiog- raphy in determining the working length in primary teeth. Conclusions: The electronic apex locators provide an ac- ceptable level of accuracy in determining root canal length in primary teeth. Clinical Relevance: The purpose of this study was to evaluate the accuracy of conven,onal radiography, intraoral digital radiovisiography and electronic apex locator in determining the working length of root canals in primary teeth and,to compare the results with scanning electron microscopy measurements.Öğe Conservative surgical treatment of the jaw cysts in children: Case study of five patients(Medknow Publications & Media Pvt Ltd, 2017) Gürler, Gökhan; Yılmaz, S.; Delilbaşı, Barış Çağrı; Dilaver, Emrah; Yüzbaşıoğlu, Emir; Patır Münevveroğlu, AslıAims: Conservative treatment of jaw cysts establishes low surgical complication risk and protects vital anatomical structures such as inferior alveolar nerve, maxillary sinus and permanent tooth germs. Marsupialization and decompression have been widely used in children. The aim of this study was to evaluate the results of the conservative treatment of jaw cysts in five children. Materials and Methods: This article presents case series of marsupialization in jaw cysts associated with impacted teeth in five children. A total of nine impacted teeth within the cystic lesions were observed. Results: Complete resolution of all cystic lesions and simultaneous eruption of six impacted teeth within the cyst were managed. The other two teeth were erupted orthodontically and one had to be extracted. Conclusions: Marsupialization is effective for the treatment of cystic lesions in growing patients as it preserves vital anatomical structures and enables eruption of the impacted teeth within the cyst.Öğe Dental management of a patient with nager acrofacial dysostosis(Hindawi Publishing Corporation, 2015) Bozatlıoğlu, Ruhan; Münevveroğlu, AslıNager syndrome is a rare syndrome resulting from developmental abnormalities of the first and second branchial arches. Nager syndrome is rare and mostly sporadic. The main clinical features consist of craniofacial, limb, and musculoskeletal morphogenesis. These findings included malar hypoplasia, maxillomandibular hypoplasia, micrognathia, downslanting palpebral fissures, cleft palate, ear anomalies, hypoplastic thumb, short forearm, proximal radioulnar synostosis, atrial septal defect, lower limb deformities, and flat nasal bridge. The prevalence is unknown; about 100 cases of Nager syndrome have been published up to now. Patients with Nager syndrome are found worldwide among all racial and ethnic groups. Trismus and glossoptosis resulting in oropharyngeal airway narrowing cause life-threatening respiratory distress for patients with Nager syndrome. In this case report, dental rehabilitation of a 10-year-old child with Nager syndrome is presented.Öğe Dental treatment of a child with pallister-killian syndrome(Hindawi Ltd, 2016) Didinen, Serhan; Atabek, Didem; Kip, Gülay; Münevveroğlu Patır, Aslı; Tulunoğlu, ÖzlemThe Pallister-Killian syndrome (PKS) is an extremely rare genetic disorder with an incidence estimated around 1/25000. PKS is a multiple congenital anomaly deficit syndrome caused by mosaic tissue limited tetrasomy for chromosome 12p. The presented report is the first confirmed case with PKS in Turkey. This report focuses on the orofacial clinical manifestations of an 6-year-old boy with PKS who was referred to the Department of Paediatric Dentistry clinic, Gazi University. It has been learned that the PKS was diagnosed 1 year after birth. Due to intellectual disability, it was decided to make the dental treatments under moderate sedation. Although significant tongue thrust and anterior open bite were determined, any oral appliances could not be applied because of the 2 epilepsy seizures in the last 2 years. The aim was to treat decayed teeth and set good oral hygiene in the patient's mouth. Still, there is a probability for epilepsy seizures. If epileptic seizures stop permanently, we can apply an oral appliance to block tongue thrust. The patient is now under control. In cases of systemic and oral findings such as PKS, conducting medical and dental approaches together will increase the life quality of patients.Öğe Effect of three different remineralizing agents on artificial erosive lesions of primary teeth(Wiley, 2022) Üstün, Nilüfer; Güven, YelizBackground This study aimed to investigate the efficacy of three remineralizing agents on dental erosion in primary teeth. Methods Forty primary molars were randomly divided into four groups (n = 10 each): self-assembling peptide (P11-4), casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP), sodium fluoride (NaF) and artificial saliva (AS; control). The erosion-like formation was created by immersing the samples in citric acid (4 x 2 min, pH 2.3) and AS (4 x 2 h, pH 7). The eroded samples were then treated with remineralizing agents and subjected to further erosion consisting of 15 cycles (3x/8-h interval) of immersion in citric acid and AS for 6 s each. Alterations in the mineral content and morphology of the samples were quantified using a microhardness tester and atomic force microscope. Results All agents had a significant remineralization effect on eroded primary tooth enamel. After further erosive challenge, enamel loss in the CPP-ACFP group was found to be significantly lower than in all other groups, and no significant difference was found between the P11-4 and NaF groups. Conclusions This study showed that all tested materials had remineralization ability, and CPP-ACFP had a superior effect in inhibiting enamel loss due to dental erosion in primary teeth.Öğe Effects of surface preparation with sodium hypochlorite on shear bond strength and residual adhesive of orthodontic brackets on primary and permanent teeth(Ankara University, 2022) Arslan, Can; Üstün, Nilüfer; Cesur, EmreObjective: To investigate the effects of surface preparation with sodium hypochlorite (NaOCl) on bracket shear bond strength and amount of residual adhesive on primary and permanent teeth. Materials and Methods: 24 permanent premolars, 12 in each group (groups I and III), and 24 primary molars, 12 in each group (groups II and IV) were included. In group I and II, 37% phosphoric acid was applied to the tooth surfaces, without using any other agent. In Group III and IV, 5.25% NaOCl was first applied. Following washing and drying, surface roughening was performed with phosphoric acid. The shear bond strengths (SBS) of the brackets bonded to the tooth surfaces was measured. After debonding, the base of each bracket was examined for adhesive remnant index (ARI) scores. Results: There were no statistically significant differences in SBS values between primary and permanent teeth with and without preparation with NaOCl(P>0.05). Mean SBS(18.55±14.98 MPa) was higher in permanent premolars subjected to surface deproteinization with NaOCl (group III) when compared with other groups, but the difference was not significant. There was no significant difference in ARI scores between the groups. Conclusions: The bond strength of orthodontic brackets or the distribution of ARI scores were similar between groups with and without NaOCl pretreatment. Hence, it can be concluded that conventional bonding procedures applied without any additional preparation to primary teeth are sufficient and the debonding of brackets didn’t cause any harm to enamel surfaces.Öğe Enamel formation genes influence enamel microhardness before and after cariogenic challenge(Public Library Science, 2012) Shimizu, Takehiko; Ho, Bao; Deeley, Kathleen; Briseno-Ruiz, Jessica; Faraco, Italo Medeiros; Schupack, Brett Ian; Brancher, Joäo Armando; Pecharki, Giovana Daniela; Küchler, Erika Calvano; Tannure, Patrícia Nivoloni; Lips, Andrea; Vieira, Thays Cristinedos Santos; Patır, Aslı; Yıldırım, Mine; Poletta, Fernando Adrián; Mereb, Juan Carlos; Resick, Judith M.; Brandon, Carla A.; Orioli, Ieda M.; Castilla, Eduardo Enrique; Marazita, Mary Louise; Seymen, Figen; Costa, Marcelo Costra; Granjeiro, José Mauro; Trevilatto, Paula Cristina; Vieira, Alexandre RezendeThere is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity.Öğe Er:YAG lazer ya da geleneksel yöntem ile hazırlanmış sınıf V kavitelerde akışkan kompozitlerin kenar uyumlarının araştırılması(Yeditepe Üniversitesi Rektörlüğü, 2021) Üstün, Nilüfer; Güven, Yeliz; Dinçer, Asiye Nur; Tuna İnce, Elif Bahar; Özel, EmreAmaç: Bu çalışmanın amacı, Er:YAG lazer ya da yüksek hızlı döner aletler ile kavite hazırlığı yapılan ve üç farklı akışkan kompozit materyali kullanılarak gerçekleştirilen sınıf V restorasyonlarda kenar mikrosızıntılarının incelenmesidir. Gereç ve Yöntem: Bu in-vitro çalışmada, toplam 33 adet üçüncü büyük azı dişlerinin bukkal ve lingual yüzeylerinde Er:YAG lazer ya da frez kullanılarak sınıf V kaviteler hazırlanan örnekler altı gruba (n=11) ayrıldı ve üretici firmanın talimatlarına uygun olarak üç farklı akışkan kompozit ile restore edildi. Grup 1: Lazer ile hazırlık (lh)+Estelite Flow Quick High flow (EF); Grup 2: lh+G-aenial Flo (GF); Grup 3: lp+Herculite XRV Ultra Akış (HF); Grup 4: Frez ile hazırlık (fh)+EF; Grup 5: fh+GF; Grup 6: fh+HF. Isısal çevrim uygulanmasının ardından örnekler %0,5 metilen mavisi solüsyonunda 24 saat süresince bekletildi. Boya penetrasyonu sonucu oluşan mikrosızıntı, stereomikroskop altında x40 büyütme ile incelendi. Verilerin analizinde Kruskal Wallis ve Mann-Whitney U testleri kullanıldı (p<0,05). Bulgular: Grup 3’te oluşan mikrosızıntı düzeyi grup 2’ye göre istatistiksel açıdan anlamlı derecede düşük bulunurken (p:0,042), diğer gruplar arasındaki mikrosızıntı düzeylerinde anlamlı bir farklılık saptanmadı. Gruplardaki gingival ve oklüzal yüzeyler karşılaştırıldığında mikrosızıntı düzeyleri arasında istatistiksel olarak anlamlı bir farklılık bulunmadı (p<0,05). Sonuç: Sınıf V kavite hazırlığında yüksek hızlı döner alet ya da Er:YAG lazer uygulaması ve bu kavitelerin restorasyonlarında farklı akışkan kompozit materyallerinin kullanılması, oklüzal ve gingival kenarlarda oluşan mikrosızıntı düzeyini etkilememektedir.Öğe Erken çocukluk döneminde travmatik diş yaralanmalarının, maloklüzyonların ve diş çürüğünün ağız sağlığı ile ilişkili yaşam kalitesi üzerine etkisi(Selcuk University, 2021) Gürcan, Aliye Tuğçe; Koruyucu, Mine; Bayram, Merve; Seymen, FigenAmaç: Bu çalışmanın amacı, travmatik diş yaralanmalarının (TDY) ve diş çürüğünün okul öncesi çocukların Ağız Sağlığı ile İlişkili Yaşam Kalitesi (OHRQoL) üzerindeki etkisini değerlendirmektir. Gereç ve Yöntemler: Ağız Sağlığı ile İlişkili Yaşam Kalitesini ölçmek için 206 okul öncesi çocuğun velisine 13 soruluk Erken Çocukluk Çağı Ağız Sağlığı Etki Ölçeği (ECOHIS) uygulanmıştır. Çocukların travmatik diş yaralanmaları, diş çürüğü (dmft skorları) ve ön bölge maloklüzyon özelliklerine bakılmıştır. Bulgular: Çocukların yaş ortalaması 4.09 ± 0.97 bulunmuştur. Diş çürüğü, Ağız Sağlığı ile İlişkili Yaşam Kalitesi üzerinde olumsuz bir etki göstermiştir. Diş çürüğü; Ağız Sağlığı ile İlişkili Yaşam Kalitesi ortalaması, semptomları, fonksiyonu, psikolojisi, ailesel sıkıntı ve aile fonksiyon alanları üzerinde olumsuz bir etki göstermiştir. Ön bölgede maloklüzyon varlığı sadece sosyal etkileşim alanı üzerinde olumsuz bir etki göstermiştir. Komplike travmatik diş yaralanmaları, komplike olmayan travmatik diş yaralanmalarına göre semptomlar açısından daha olumsuz bir etki göstermiştir. Sonuç: Travmatik dental yaralanma ve maloklüzyon gözlenen dişin varlığı, okul öncesi çocukların Ağız Sağlığı ile İlişkili Yaşam Kalitesi üzerinde yalnızca çocuk alanında olumsuz bir etkiye sahiptir; ancak, diş çürüğü, hem çocuk alanında hem aile alanında Ağız Sağlığı ile İlişkili Yaşam Kalitesi ile güçlü bir ilişkiye sahiptir.Öğe Estetik restoratif materyallerin cila işlemlerinden sonra yüzey yapısının sem ile incelenmesi(Atatürk Üniversitesi, 2012) Yıldırım, Mine; Patır, Aslı; Seymen, Figen; Gençay, KorayAmaç: Bu çalışmanın amacı, ışıkla polimerize olan iki farklı cam iyonomer materyali ile iki farklı posterior bölge kompozit materyalinin yüzey özelliklerini cila işlemleri uygulandıktan sonra analiz etmektir. Gereç-Yöntem: Boyutları 2mmX5mm olan silindir şeklindeki kalıplara her malzemeden 8’er örnek olacak şekilde tabakalama yöntemi ile numuneler yerleştirilmiş ve polimerizasyon sağlanmıştır (n:32). Aynı gün içerisinde numunelerin üzerine ayrı ayrı, sadece Sof-Lex disk (1), sadece cila lastikleri (2), Sof- Lex disk ve cila lastikleri (3), strip band (kontrol) (4) ile cila uygulanmıştır. Yüzey özellikleri SEM ile değerlendirilmiştir. Bulgular: Posterior bölge kompozit materyali olan Filtek Silorane, Filtek Supreme XT’den daha düzenli yüzey yapısı gösterirken, ışıkla polimerize olan cam iyonomerlerden Ketac Nano, Vitremerden daha düzenli yüzey yapısı göstermiştir. Düzenli yüzey yapısı, Filtrek Silorane için sırasıyla grup (3),(1),(2),(4) ile cilalandığında belirgin olarak görülmüştür. Ketac Nano için tüm gruplarda düzenli yüzey yapısı grup (3),(2),(4),(1) ile bitirme ve cila işlemi tamamlandığında görülmüştür. Sonuç: Kompozit materyallerinden Filtek Silorane, Filtek Supreme XT’den daha düzenli yüzey yapısı gösterirken, cam iyonomer materyallerinden Ketac Nano, Vitremerden daha düzenli yüzey yapısı göstermektedir. SEM analizlerine göre, en iyi cilalı yüzey Sof-lex disk ve ardından cila lastikleri kullanıldığında sağlanabilinmektedir.
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