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Öğe Abnormalities of cortical sources of resting state alpha electroencephalographic rhythms are related to education attainment in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment(NLM (Medline), 2021) Babiloni, Claudio C.; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Panzavolta, Andrea; Soricelli, Andrea; Nobili, Flavio Mariano; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hano?lu, Lütfü; Yener, Görsev G.; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Glovannl B.; del Percio, ClaudioIn normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.Öğe Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases(Elsevier Science Inc, 2019) Babiloni, Claudio; del Percio, Claudio; Pascarelli, Maria Teresa; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Rizzo, Marco; Ferri, Rafaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Salvetti, Marco; Cipollini, Virginia; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Farotti, Lucia; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lütfü; Yener, Görsev; Emek Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Hampel, Harald; Frisoni, Giovanni B.; de Pandis, Maria Francesca; Bonanni, LauraPrevious evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.Öğe Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases(IOS Press, 2018) Babiloni, Claudio; del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Aarsland, Dag; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Garn, Heinrich; Fraioli, Lucia; Pievani, Michela; Frisoni, Giovanni B.; D'Antonio, Fabrizia; de Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lütfü; Başar, Erol; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Franciotti, Raffaella; Taylor, John Paul; de Pandis, Maria Francesca; Bonanni, LauraThe present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.Öğe Abnormalities of resting-state functional cortical connectivity in patients with dementia due to alzheimer's and lewy body diseases: An EEG study(Elsevier Science Inc, 2018) Babiloni, Claudio; del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Aarsland, Dag; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Garn, Heinrich; Fraioli, Lucia; Pievani, Michela; Frisoni, Giovanni B.; D'Antonio, Fabrizia; de Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lütfü; Bazar, Erol; Yener, Görsev; Emek Savaş, Derya Durusu; Triggiani, Antonio Ivano; Franciotti, Raffaella; Taylor, John Paul; Vacca, Laura; de Pandis, Maria Francesca; Bonanni, LauraPrevious evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values>0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels.Öğe EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel(Elsevier Inc., 2021) Babiloni, Claudio C.; Arakaki, Xianghong; Bonanni, Laura; Buján, Ana; Carrillo, María C.; del Percio, Claudio; Edelmayer, Rebecca M.; Egan, Gary; Elahh, Fanny M.; Evans, Alan Charles; Ferri, Raffaele; Frisoni, Glovannl B.; Güntekin, Bahar; Hainsworth, Atticus Henry; Hampel, Harald; Jeli?, Vesna; Jeong, Jaeseung; Kim, Doh-kwan; Kramberger, Milica Gregori?; Kumar, Sanjeev; Lizio, Roberta; Nobili, Flavio Mariano; Noce, Giuseppe; Puce, Aina; Ritter, Petra; Smit, Dirk J.A.; Soricelli, Andrea; Teipel, S.; Tucci, FedericoVascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8–12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4–8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants’ responses in “oddball” paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as “neural synchronization” biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.Öğe Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms(Elsevier Science Inc, 2019) Babiloni, Claudio; del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentine; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; de Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lütfü; Yener, Görsev; Emek Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; de Pandis, Maria FrancescaWe hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.Öğe Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel(Wiley, 2021) Babiloni, Claudio; Arakaki, Xianghong; Azami, Hamed; Bennys, Karim; Blinowska, Katarzyna; Bonanni, Laura; Bujan, Ana; Carrillo, Maria C.; Cichocki, Andrzej; de Frutos-Lucas, Jaisalmer; del Percio, Claudio; Dubois, Bruno; Edelmayer, Rebecca; Egan, Gary; Epelbaum, Stephane; Escudero, Javier; Evans, Alan; Farina, Francesca; Fargo, Keith; Fernandez, Alberto; Ferri, Raffaele; Frisoni, Giovanni; Hampel, Harald; Harrington, Michael G.; Jelic, Vesna; Jeong, Jaeseung; Jiang, Yang; Kaminski, Maciej; Kavcic, Voyko; Kilborn, Kerry; Kumar, Sanjeev; Lam, Alice; Lim, Lew; Lizio, Roberta; Lopez, David; Lopez, Susanna; Lucey, Brendan; Maestu, Fernando; McGeown, William J.; McKeith, Ian; Moretti, Davide Vito; Nobili, Flavio; Noce, Giuseppe; Olichney, John; Onofrj, Marco; Osorio, Ricardo; Parra-Rodriguez, Mario; Rajji, Tarek; Ritter, Petra; Soricelli, Andrea; Stocchi, Fabrizio; Tarnanas, Ioannis; Taylor, John Paul; Teipel, Stefan; Tucci, Federico; Valdes-Sosa, Mitchell; Valdes-Sosa, Pedro; Weiergraeber, Marco; Yener, Görsev; Güntekin, BaharThe Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and "interrelatedness" rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.Öğe Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms(Frontiers Media S.A., 2023) Lopez, Susanna; del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Padovani, Alessandro; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Babiloni, ClaudioIntroductionGraph theory models a network by its nodes (the fundamental unit by which graphs are formed) and connections. 'Degree' hubs reflect node centrality (the connection rate), while 'connector' hubs are those linked to several clusters of nodes (mainly long-range connections). MethodsHere, we compared hubs modeled from measures of interdependencies of between-electrode resting-state eyes-closed electroencephalography (rsEEG) rhythms in normal elderly (Nold) and Alzheimer's disease dementia (ADD) participants. At least 5 min of rsEEG was recorded and analyzed. As ADD is considered a 'network disease' and is typically associated with abnormal rsEEG delta (<4 Hz) and alpha rhythms (8-12 Hz) over associative posterior areas, we tested the hypothesis of abnormal posterior hubs from measures of interdependencies of rsEEG rhythms from delta to gamma bands (2-40 Hz) using eLORETA bivariate and multivariate-directional techniques in ADD participants versus Nold participants. Three different definitions of 'connector' hub were used. ResultsConvergent results showed that in both the Nold and ADD groups there were significant parietal 'degree' and 'connector' hubs derived from alpha rhythms. These hubs had a prominent outward 'directionality' in the two groups, but that 'directionality' was lower in ADD participants than in Nold participants. DiscussionIn conclusion, independent methodologies and hub definitions suggest that ADD patients may be characterized by low outward 'directionality' of partially preserved parietal 'degree' and 'connector' hubs derived from rsEEG alpha rhythms.Öğe Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease(Elsevier Inc., 2024) Babiloni, Claudio; Noce, Giuseppe; Tucci, Federico; Jakhar, Dharmendra; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; del Percio, ClaudioHere, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources. Results showed substantial (greater than ?10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the PDD group than in the healthy control seniors and the ADD patients. These results suggest that PDD patients show poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. That neurophysiological biomarker may provide an endpoint for (non) pharmacological interventions for improving vigilance regulation in those patients.Öğe qEEG methods to probe abnormal brain rhythms related to quiet vigilance in patients with dementia due to Alzheimer’s, Parkinson’s, and lewy body diseases(Humana Press Inc., 2024) Babiloni, Claudio; Güntekin, Bahar; Yener, Görsev; del Percio, ClaudioHere, we discuss relevant literature findings on abnormal resting-state scalp-recorded electroencephalographic (rsEEG) rhythms in old patients with severe cognitive deficits and disabilities in activities of daily living (i.e., dementia) due to Alzheimer’s (ADD), Parkinson’s (PDD), and Lewy body (DLB) neurodegenerative diseases. Furthermore, we described a modern quantitative EEG (qEEG) methodology to explore those rhythms and related vigilance disorders. The reviewed findings unveil consistent abnormalities in topographic and frequency (most in <12 Hz) features of the rsEEG rhythms recorded in ADD, PDD, and DLB patients, probably reflecting altered neurophysiological oscillatory mechanisms of synchronization and functional connectivity in neural brain populations underpinning the regulation and maintenance of the quiet vigilance. The proposed qEEG methodology showed significant differences in the posterior cortical sources of rsEEG alpha rhythms at individual frequencies among small groups of ADD, PDD, and DLB patients. Although the above abnormalities may have a limited diagnostic value at the individual level, not specifically reflecting the neuropathological processes underlying ADD, PDD, and DLB, they have significant heuristic and clinical relevance. Namely, the rsEEG readouts at the alpha frequencies unveiled the altered neurophysiological oscillatory mechanisms responsible for vigilance disorders in ADD, PDD, and DLB patients and may be used as pathophysiological biomarkers to evaluate the efficacy of (non)pharmacological interventions to treat those disorders. We recommend using the present qEEG methodology in longitudinal rsEEG studies carried out in ADD, PDD, and DLB patients to explore the abnormalities in the rsEEG biomarkers of vigilance dysregulations during the disease progression.Öğe Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease(Oxford University Press Inc., 2023) Babiloni, Claudio; Lopez, Susanna; Noce, Giuseppe; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; Salvatore, Marco; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Massa, Federico; Buttinelli, Carla; Giubilei, Franco; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; D'Antonio, Fabrizia; Bruno, Giuseppe; de Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Yerlikaya, Deniz; Taylor, John Paul; Schumacher, Julia; Mckeith, Ian; Bonanni, Laura; Pantano, Patrizia; Piervincenzi, Claudia; Petsas, Nikolaos; Frisoni, Giovanni B.; del Percio, Claudio; Carducci, FilippoHere we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.Öğe Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study(Oxford University Press Inc, 2022) Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B.; del Percio, ClaudioIn the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.Öğe Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment(IOS Press, 2021) Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; del Percio, ClaudioBackground: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8-13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8-12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with mild cognitive impairment due to Alzheimer's disease (ADMCI). Methods: Clinical and rsEEG datasets in 63 ADMCI and 60 Nold individuals (matched for demography, education, and gender) were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands, as well as fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Results: As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical effects in posterior regions. On the contrary, in relation to the younger ADMCI subgroups, the older one displayed a lesser reduction in those rhythms. Notably, the ADMCI subgroups pointed to similar cerebrospinal fluid AD diagnostic biomarkers, gray and white matter brain lesions revealed by neuroimaging, and clinical and neuropsychological scores. Conclusion: The present results suggest that age may represent a deranging factor for dominant rsEEG alpha rhythms in Nold seniors, while rsEEG alpha rhythms in ADMCI patients may be more affected by the disease variants related to earlier versus later onset of the AD.Öğe Resting state electroencephalographic alpha rhythms predict and are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up(Elsevier, 2023) Babiloni, C.; Noce, G.; del Percio, Claudio; Tucci, F.; Lopez, S.; Ferri, R.; Soricelli, A.; Arnaldi, D.; Giubilei, F.; Stocchi, F.; Güntekin, Bahar; Yener, Görsev; Taylor, J. P.; Pantano, P.; Piervincenzi, Claudia; Nikolaos, Petsas; Frisoni, Giovanni B.; Jakhar, DeepakIntroduction: Patients with Alzheimer’s disease and mild cognitive impairment (ADMCI) suffer not only from severe cognitive deficits and disabilities in daily living but also from vigilance dysregulation reflected by substantial hypersomnolence due to vigilance fluctuations. Therefore, we hypothesized that such vigilance dysregulation in ADMCI patients might be reflected by altered electroencephalographic (rsEEG) rhythms recorded in a resting-state eyes-closed condition in relation to the disease progression at 6-month follow-ups.Öğe What a single electroencephalographic (EEG) channel can tell us about alzheimer's disease patients with mild cognitive impairment(NLM (Medline), 2023) del Percio, Claudio; Lopez, Susanna; Noce, Giuseppe; Lizio, Roberta; Tucci, Federico; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Marizzoni, Moira; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; Babiloni, ClaudioAbnormalities in cortical sources of resting-state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10-20 montage) with 19 scalp electrodes characterized Alzheimer's disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluation of AD progression in large populations with few electrodes in low-cost devices. Here we evaluated whether the above-mentioned abnormalities can be observed from fewer scalp electrodes in patients with mild cognitive impairment due to AD (ADMCI). Clinical and rsEEG data acquired in hospital settings (10-20 montage) from 75 ADMCI participants and 70 age-, education-, and sex-matched normal elderly controls (Nold) were available in an Italian-Turkish archive (PDWAVES Consortium; www.pdwaves.eu). Standard spectral fast fourier transform (FFT) analysis of rsEEG data for individual delta, theta, and alpha frequency bands was computed from 6 monopolar scalp electrodes to derive bipolar C3-P3, C4-P4, P3-O1, and P4-O2 markers. The ADMCI group showed increased delta and decreased alpha power density at the C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels compared to the Nold group. Increased theta power density for ADMCI patients was observed only at the C3-P3 bipolar channel. Best classification accuracy between the ADMCI and Nold individuals reached 81% (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from six posterior bipolar channels characterized ADMCI status. These results may pave the way toward diffuse clinical applications in health monitoring of dementia using low-cost EEG systems with a strict number of electrodes in lower- and middle-income countries.
