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    A windowing technique for optimal time-frequency concentration and aci rejection in ofdm-based systems
    (Institute of Electrical and Electronics Engineers, 2015) Güvenkaya, Ertu?rul; Şahin, Alphan; Bala, Erdem; Yang, Rui; Arslan, Hüseyin
    In this paper, we introduce a windowing technique, which provides optimal time-frequency containment and maximal adjacent channel interference (ACI) rejection for orthogonal frequency-division multiplexing (OFDM)-based systems. Instead of using a single pulse shape function for all subcarriers, multiple functions are considered in order to maximize the time-frequency containment of the OFDM waveform. The main strategy is to concentrate the spectrum of windowing functions into a given bandwidth while achieving maximum suppression in the out-of-band region. This is achieved by employing prolate-based windowing functions which give optimal spectral concentration for time-limited pulse shapes. The windowing functions are designed per-subcarrier basis in order to exploit available concentration band for each subcarrier. In addition, the proposed concept is considered for the receive filtering in the presence of ACI. It is shown that the optimal spectral concentration property also maximizes ACI rejection for OFDM receivers.
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    Impaired IL-23-dependent induction of IFN-gamma underlies mycobacterial disease in patients with inherited TYK2 deficiency
    (Rockefeller University Press, 2022) Ogishi, Masato; Augusto Arias, Andres; Yang, Rui; Han, Ji Eun; Zhang, Peng; Rinchai, Darawan; Halpern, Joshua; Mulwa, Jeanette; Keating, Narelle; Chrabieh, Maya; Laine, Candice; Seeleuthner, Yoann; Ramirez-Alejo, Noe; Nekooie-Marnany, Nioosha; Guennoun, Andrea; Muller-Fleckenstein, Ingrid; Fleckenstein, Bernhard; Kılıç, Sara Şebnem; Minegishi, Yoshiyuki; Ehl, Stephan; Kaiser-Labusch, Petra; Kendir-Demirkol, Yasemin; Rozenberg, Flore; Errami, Abderrahmane; Zhang, Shen-Ying; Zhang, Qian; Bohlen, Jonathan; Puel, Anne; Jouanguy, Emmanuelle; Pourmoghaddas, Zahra; Bakhtiar, Shahrzad; Willasch, Andre M.; Horneff, Gerd; Llanora, Genevieve; Shek, Lynette P.; Chai, Louis Y. A.; Tay, Sen Hee; Rahimi, Hamid H.; Mahdaviani, Seyed Alireza; Nepesov, Serdar; Bousfiha, Aziz A.; Erdeniz, Emine Hafize; Karbuz, Adem; Marr, Nico; Navarrete, Carmen; Adeli, Mehdi; Hammarstrom, Lennart; Abolhassani, Hassan; Parvaneh, Nima; Al Muhsen, Saleh; Alosaimi, Mohammed F.; Alsohime, Fahad; Nourizadeh, Maryam; Moin, Mostafa; Arnaout, Rand; Alshareef, Saad; El-Baghdadi, Jamila; Genel, Ferah; Sherkat, Roya; Kıykım, Ayça; Yücel, Esra; Keleş, Sevgi; Bustamante, Jacinta; Abel, Laurent; Casanova, Jean-Laurent; Boisson-Dupuis, Stephanie
    Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-alpha/beta (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). Cells homozygous for the common P1104A TYK2 allele have selectively impaired responses to IL-23 (underlying isolated mycobacterial disease). We report three new forms of TYK2 deficiency in six patients from five families homozygous for rare TYK2 alleles (R864C, G996R, G634E, or G1010D) or compound heterozygous for P1104A and a rare allele (A928V). All these missense alleles encode detectable proteins. The R864C and G1010D alleles are hypomorphic and loss-of-function (LOF), respectively, across signaling pathways. By contrast, hypomorphic G996R, G634E, and A928V mutations selectively impair responses to IL-23, like P1104A. Impairment of the IL-23-dependent induction of IFN-gamma is the only mechanism of mycobacterial disease common to patients with complete TYK2 deficiency with or without TYK2 expression, partial TYK2 deficiency across signaling pathways, or rare or common partial TYK2 deficiency specific for IL-23 signaling.
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    Partially overlapping tones for uncoordinated networks
    (Institute of Electrical and Electronics Engineers, 2014) Şahin, Alphan; Bala, Erdem; Güvenç, İsmail; Yang, Rui; Arslan, Hüseyin
    In an uncoordinated network, the link-level performance of a wireless receiver might degrade significantly due to the interference from other transmitters that share the same spectrum. As a solution, in this study, the concept of partially overlapping tones (POT) is introduced. In POT, interference energy observed at a victim receiver is mitigated by partially overlapping the individual subcarriers via an intentional carrier frequency offset between the links. It is argued that the self-interference arising due to the use of POT can be more easily addressed than the dominant other-user interference, potentially yielding higher spectral efficiencies with POT. Using a spatial Poisson point process based framework, a tractable bit error rate analysis is provided to demonstrate potential benefits emerging from POT in system-level scenarios.
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    Time-asymmetric and subcarrier-specific pulse shaping in ofdm-based waveforms
    (Institute of Electrical and Electronics Engineers, 2015) Güvenkaya, Ertu?rul; Bala, Erdem; Yang, Rui; Arslan, Hüseyin
    In orthogonal frequency-division multiplexing (OFDM) systems, suppressing the out-of-band (OOB) emission with pulse shaping comes with a price. The expense emerges in designing the transition between consecutive symbols. The price can be either the reduction of spectral efficiency (SE) with symbol extension for better transition or the introduction of intersymbol and intercarrier interference (ISI and ICI) due to reduced cyclic prefix (CP) size. In this paper, we propose a time-asymmetric and per-subcarrier (per-SC) pulse-shaping method to minimize the introduced interference without sacrificing SE and OOB performances. Although time-asymmetric pulse reduces the interference due to shortened CP by exploiting the asymmetry in channel delay profile, it causes spectral growth. Thus, the time asymmetry of the pulse-shaping function is gradually increased for the inner SCs that have wider spectral room to the OOB region. A generalized Kaiser window with adjustable time asymmetry is introduced to the provided framework. Theoretical and simulation results showed that the proposed technique achieves superior BER performance while achieving the same level of OOB suppression of pulse shaping and SE of plain OFDM.