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    Impact of pulsatile flow on vital organ recovery during cardiopulmonary bypass in neonates and infants
    (Wiley-Blackwell, 2016) Ündar, Akif; Wang, Shigang; Palanzo, David; Wise, Robert; Woitas, Karl; Baer, Larry; Kunselman, Allen; Song, Jianxun; Alkan Bozkaya, Tijen; Akçevin, Atıf; Spencer, Shannon; Ağırbaşlı, Mehmet Ali; Clark, Joseph; Myers, John
    Despite advances in surgical techniques and medical management, congenital heart defects still have a significant impact on morbidity, mortality, and healthcare costs. Based on the Society of Thoracic Surgeon’s Fall 2014 database, neonates (0–30 days) have the highest congenital heart surgery mortality rate of 9.6% (9.1–10.1%), while infants (31 days to 1 year) 3.0% (2.8–3.2%) and children (>1 year–18 years) 1.1% (1.0–1.2%) follow over the last 4 years (1). Vital organ injury during and after neonatal and infant cardiopulmonary bypass (CPB) procedures is considered to be a main cause (2–5). The reasons for this are multifactorial. Hundreds of articles have already been published on the major causes including systemic inflammatory response syndrome, deep hypothermic circulatory arrest, ischemia/reperfusion injury, hematocrit levels, degree of hypothermia, pH versus alpha stat strategies, and nonpulsatile versus pulsatile perfusion (6–8). Among them, perfusion mode is still a matter of controversy.
  • Küçük Resim
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    Outcomes of the 10th international conference on pediatric mechanical circulatory support systems and pediatric cardiopulmonary perfusion
    (Blackwell Publishing, 2015) Ündar, Akif; Ravishankar, Chitra; Wang, Shigang; Pekkan, Kerem; Akçevin, Atıf; Luciani, Giovanni Battista
    The 10th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion was held at the Hall of Flags, University of Pennsylvania, Philadelphia, PA, USA, May 28–31, 2014. The overall objective of the meeting has been and still is to bring together internationally known clinicians, bioengineers, and basic scientists involved in research on pediatric mechanical circulatory support (MCS) systems and pediatric cardiopulmonary bypass (CPB) procedures. Primarily, we focus to explicitly describe the problems with current pediatric mechanical circulatory support systems, methods, and techniques during acute and chronic support, and to suggest solutions and future directions for research. Year after year, we not only maintain our primary objective, but also improve by adding several wet-labs with cutting-edge new devices along with in vivo experiments (1–4).