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Öğe Accelerated long-term forgetting after amygdalohippocampectomy in temporal lobe epilepsy(Elsevier, 2020) Polat, Burcu; Helvacı Yılmaz, Nesrin; Mantar, Nagihan; Çadırcı, Fadime; Sitrava, Sevilay; Ozmansur, Elif Nurdan; Uzan, Mustafa; Özkara, Çiğdem; Hano?lu, LütfüAim of the study: Temporal lobe epilepsy (TLE) has been associated with the phenomenon of accelerated long-term forgetting (ALF). In this study, we aimed to demonstrate the effect of surgery on the ALF phenomena thus contributing to potential explanation of the causal mechanism.Materials and methods: We evaluated 51 patients with TLE related to hippocampal sclerosis who had amygdalohippocampectomy and had remained seizure-free after surgery. A control group consisted of 24 healthy individuals. All were given a verbal learning test assessing recall after 30 min, 1 week and 6 weeks.Results: In our study, the Left-TLE (L-TLE) group showed a statistically significant reduction in the performance at all assessment intervals from 30 min to 1 week compared to the Right-TLE and control groups regarding verbal learning memory test (VLMT) as well as for logical memory. The forgetting rates in the VLMT from 30 min to 1 week were not statistically significantly different between all 3 groups. The logical memory test results equally showed no statistically significant difference in the forgetting rates for the 3 groups between 30 min and 1 week.Conclusions and clinical implications: These results may support ongoing debates assuming the initial low performance in the memory of L-TLE patients to be directly related with left hippocampal-temporal tissue loss irrespective of epileptic activity. The discovery of the ALF phenomenon explains that standard memory tests are unable to detect memory loss in some patients who are experiencing a significant level of problems with forgetfulness in their daily lives.Öğe Accelerated long-term forgetting, subjective memory complaints and depression in medial temporal lobe epilepsy(Wiley-Blackwell, 2012) Yağcı, Selin; Uzan, Mustafa; Hanoğlu, Lütfü; Özkara, Çiğdem[Abstract Not Available]Öğe Relationship between the wada test and preoperative/postoperative memory in mesial temporal lobe epilepsy patients(Kare Publishing, 2013) Hanoğlu, Lütfü; Helvacı Yılmaz, Nesrin; Özkara, Çiğdem; Polat, Burcu; Demirci, Sema; Uzan, MustafaObjectives: To study the correlation between Wada memory test and neuropsychometric tests which were applied preoperatively to mesial temporal lobe epilepsy patients associated with hippocampal sclerosis (MTLE-HS) who had undergone selective amygdalohippocampectomy and find out the effects of early onset epileptic seizures on atypical memory dominance. Methods: Drug-resistant 27 patients (16 left, 11 right MTLE-HS) had video EEG, cranial MRI and Wada test preoperatively. Weschler visual subtest and verbal memory processing tests were applied to all patients before surgery and the first year after the operation. Results: The number of left hemisphere memory dominant patients was 6 (22.2%) and the number of atypical memory dominant patients was 21 (77.8%) according to the Wada test. There was a significant difference between the two groups when compared for epileptic seizure onset age; (p=0.042), and also a significant diffference when compared for HS (right/left) side (p=0.002). When we analyzed the correlation between preoperative and postoperative verbal and nonverbal tests and left memory Wada dominance; in verbal memory processing tests ‘delayed recall’ scores between groups were significant (p=0.042), on the other hand in patients with atypical memory dominance ‘total learning’ scores between groups were significant (p<0.001). Conclusion: As a result, we found that the earlier the onset of seizures, the more atypical the memory dominance (right or bilateral). The Wada test was effective for assessing verbal memory; on the other hand, it was inadequate for assessing visual memory dominance. If the scores of ‘delayed recall’ in verbal memory were high in the patients with typical verbal dominance and ‘total learning’ scores in the patients with atypical verbal dominance, the scores also tended to rise after the operation.Öğe Temporal lob epilepside lateralize edici bulgu olarak materyal spesifik bellek bozukluğu(Kare Publishing, 2014) Hanoğlu, Lütfü; Şengül, Hakan Serdar; Erbayat, Ebru; Özmansur, Elif Nurdan; Keskinkılıç, Cahit; Demirci, Sema; Polat, Burcu; Yılmaz, Nesrin; Uzan, Mustafa; Özkara, ÇiğdemAmaç: Belleğin materyal spesifik özelliği ile verbal bellek sol, nonverbal bellek de sağ temporal bölge ile ilişkilendirilir. Bu çalışmada hastaların bireysel olarak cerrahi öncesi dönemde verbal ve nonverbal bellek işlevleri incelenmiştir. Gereç ve Yöntem: İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi’nde temporal lob epilepsisi (TLE) tanısı almış ve cerrahi tedaviye hazırlanmış toplam 137 hastada, (70 erkek ve 67 kadın) verbal ve nonverbal bellek testlerinin sonuçları nöbetlerin başladığı taraf (sağ, n=73, sol, n=56 veya iki taraflı n=8) ile olan ilişkileri bakımından incelenmiştir. Verbal bellek için sözel bellek süreçleri testi (SBST) ve nonverbal bellek işlevleri için Wechsler Memory Scale görsel alt test (WMS/G) testleri uygulanmıştır. Bulgular: Sol TLE’li hastaların %44.6’sı, sağ TLE’li hastaların ise %5.5’i materyal spesifik bellek bozukluğu göstermiştir. Hastaların büyük çoğunluğunda hem verbal, hem de nonverbal bellek testleri normal sınırlar içerisinde izlenmiştir (sol TLE %28.6/sağ TLE %50.7). Ayrıca hem verbal, hem de nonverbal belleğin etkilendiği, “global” bir etkilenme de oldukça sık izlenmiştir (sol TLE %21.4/sağ TLE %17.8). Sol TLE’li hastalarda sağ temporal loba atfedilen nonverbal bellekte düşük performans gösteren hasta sayısı az (%5.4) iken sağ TLE’li hastalarda bu oran oldukça yüksektir (%26). Sonuç: Bireysel değerlendirmede sağ TLE’li hastalarda karşı tarafa ait materyal spesifik bellekte düşük performans izlenmesi materyal spesifite teorisinin gözden geçirilmesini gerektirir.
