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    Acromegaly is associated with a distinct oral and gut microbiota
    (Springer, 2022) Şahin, Serdar; Gündoğdu, Aycan; Nalbantoğlu, Ufuk; Kadıoğlu, Pınar; Karaca, Züleyha; Hacıoğlu, Ayşa; Urhan, Muhammed Emre; Ünlühızarcı, Kürşad; Demir, Ahmet Numan; Hora, Mehmet; Durcan, Emre; Elbüken, Gülşah; Dökmetaş, Hatice Sebile; Zuhur, Sayid Shafi; Keleştemur, Fahrettin
    Purpose Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Methods Oral and fecal samples were collected from patients with newly diagnosed acromegaly without comorbidities and from healthy controls. The composition of the microbiota was analyzed. The general characteristics, oral and stool samples of the patients and healthy control subjects were compared. The changes in microbiota composition in both habitats, their correlations and associations with IGF-1 were statistically observed using machine learning models. Results Fifteen patients with newly diagnosed acromegaly without comorbidities and 15 healthy controls were included in the study. There was good agreement between fecal and oral microbiota in patients with acromegaly (p = 0.03). Oral microbiota diversity was significantly increased in patients with acromegaly (p < 0.01). In the fecal microbiota, the Firmicutes/Bacteroidetes ratio was lower in patients with acromegaly than in healthy controls (p = 0.011). Application of the transfer learned model to the pattern of microbiota allowed us to identify the patients with acromegaly with perfect accuracy. Conclusions Patients with acromegaly have their own oral and gut microbiota even if they do not have acromegaly-related complications. Moreover, the excess IGF-1 levels could be correctly predicted based on the pattern of the microbiome.
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    Gut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional study
    (Springer, 2021) Hacıoğlu, Ayşa; Gündoğdu, Aycan; Nalbantoğlu, Ufuk; Karaca, Züleyha; Urhan, Muhammed Emre; Şahin, Serdar; Dökmetaş, Hatice Sebile; Kadıoğlu, Pınar; Keleştimur, Fahrettin
    Purpose Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly. Method Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index. Results Seven patients (three male, four female) with a mean age of 48 +/- 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group. Conclusion The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.