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  • Küçük Resim
    Öğe
    Chemopreventive effects of hydatid disease on experimental breast cancer
    (Asian Pacific Organization for Cancer Prevention, 2015) Altun, Ahmet; Saraydın, Serpil Ünver; Soylu, Sinan; İnan, Deniz Şahin; Yastı, Çınar; Özdenkaya, Yaşar; Köksal, Binnur; Düger, Cevdet; İşbir, Cemil; Turan, Mustafa
    Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.
  • Küçük Resim
    Öğe
    Liver resection with a new technique
    (Sivas Cumhuriyet Üniversitesi, 2014) Turan, Mustafa; Karadayı, Kürşat; Şen, Metin; Yastı, Çınar; Soylu, Sinan; Özdenkaya, Yaşar; Düger, Cevdet; İşbir, Cemil
    Aim. In this retrospective study, we scrutinized the patients in whom we had used Radio- Frequency (RF) technique in liver resection procedures. Methods. In this retrospective study, indications for liver resection were malignant tumors in 17 (Elective cases) and 6 patients with trauma etiology (Emergency cases). Results. Left lateral segmentectomy (segments II-III) was done in 9 patients. Segment VI resection was performed in 4 patients. Non-anatomical (wedge) resections were done in 10 patients. The average time necessary for transection of the liver parenchyma was 34±5 min. in Elective group and 37±5min. in Emergency group. Average blood loss was 32±5 mL in Elective group and 89±8 mL in Emergency group. In the postoperative period, we did not see any subcapsular or perihepatic hematoma responsible for delayed hemorrhage. No signs of infectious disease or abscesses were observed. Conclusion. This RF assisted technique is effective in bloodless liver resections.