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    Acne in pregnancy: A prospective multicenter, cross-sectional study of 295 patients in Turkey
    (Wiley, 2020) Kutlu, Ömer; Karadağ, Ayşe Serap; Ünal, Emine; Kelekçi, Kıymet Handan; Yalçınkaya İyidal, Ayşegül; Topaloğlu Demir, Filiz; Aksoy, Berna; Çölgeçen, Emine; Tosun, Mustafa; Emre, Selma; Tatlıparmak, Aslı; Demirseren, Duriye Deniz; Kaya Özden, Hatice; Öztürk, Murat; Özlü, Emin; Chen, Wenchieh
    Background There are only a few studies on acne in pregnancy. This study was aimed to investigate the demographic, clinical, and familial characteristics of acne in pregnancy, triggering factors including endocrine diseases, and association of these findings with acne in different trimesters of pregnancy. Methods Pregnant women aged 18 years and older with acne at any stage of pregnancy were consecutively interviewed at the participating centers during the study period from 2016 to 2019. Acne severity was evaluated using the Comprehensive Acne Severity Scale. Results A total of 295 pregnant women with acne were included, with 167 (56.6%) patients showing mild, 87 (29.5%) moderate, six (12.2%) severe, and five (1.7%) very severe acne. Truncal acne was significantly higher in the third trimester than in the other stages (P < 0.001). Onset of acne before pregnancy, prepubertal, pubertal or adult onset, or acne history in previous pregnancies did not influence acne severity in pregnancy. Women with irregular menstruation before pregnancy, polycystic ovary syndrome, hirsutism, and higher body weight index tended to show severe acne in pregnancy. Conclusions Severe acne during pregnancy is generally uncommon, while severity of facial acne, truncal acne, and hirsutism is higher in the third trimester than in other trimesters. Acne in pregnancy shares many characteristics with female adult acne. Substantial changes in different kinds of hormones play a more complex role in acne during pregnancy, but the pathogenesis remains to be determined.
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    Skin manifestations following anti-COVID-19 vaccination: A multicentricstudy from Turkey
    (Wiley, 2023) Topal, İlteriş Oğuz; Tokmak, Aslı; Kurmuş, Gökçe Işıl; Kalkan, Göknur; Demirseren, Düriye Deniz; Tosun, Mustafa; Emre, Selma; Özkök Akbulut, Tuğba; Kaya Özden, Hatice; Koska, Mahmut Can; Külcü Çakmak, Seray; Kutlu, Ömer; Mutlu, Emine; Gür Aksoy, Güneş; Topaloğlu Demir, Filiz; Karadağ, Ayşe Serap
    Purpose: After the emergence of the pandemic caused by the COVID-19 virus, vaccination with various vaccines has started to be implemented across the world. To identify dermatological reactions developing after the COVID-19 vaccines administered in Turkey and determine their clinical features and risk factors that may play a role in their development. Materials and Methods: The study included patients aged ?18 years, who presented to 13 different dermatology clinics in Turkey between July 2021 and September 2021 after developing dermatological reactions following the administration of the COVID-19 vaccine. After providing written consent, the patients were asked to complete a standard survey including questions related to age, gender, occupation, comorbidities, the regular medication used, the onset of cutaneous reactions after vaccination, and localization of reactions. Dermatological reactions were categorized according to whether they developed after the first or second dose of the vaccine or whether they occurred after the inactivated or messenger RNA (mRNA) vaccine. The relationship between dermatological reactions and some variables such as gender and comorbidities was also evaluated. Results: A total of 269 patients [116 women (43.1%), 153 men (56.9%)] were included in the study. It was observed that the dermatological diseases and reactions that most frequently developed after vaccination were urticaria (25.7%), herpes zoster (24.9%), maculopapular eruption (12.3%), and pityriasis rosea (4.5%). The rate of dermatological reactions was 60.6% after the administration of the mRNA vaccine and 39.4% after that of the inactivated vaccine. There was a statistically significantly higher number of reactions among the patients that received the mRNA vaccine (p = 0.001). Conclusion: The most common reactions in our sample were urticaria, herpes zoster, and maculopapular eruption. Physicians should know the dermatological side effects of COVID-19 vaccines and their clinical features.