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Öğe A new pathogenic variant in the TRIOBP associated with profound deafness is remediable with cochlear implantation(Karger, 2021) Tekin, Ahmet Mahmut; de Ceulaer, Geert; Govaerts, Paul; Bayazıt, Yıldırım; Wuyts, Wim; van de Heyning, Paul; Topsakal, VedatBackground and Objectives: A rare type of nonsyndromic autosomal recessive hereditary hearing loss is caused by pathogenic mutations in the TRIOBP gene mostly involving exons 6 and 7. These mutations cause hearing loss originating from dysfunction of sensory inner ear hair cells. Of all the affected siblings, 2 brothers and 1 sister, part of an Afghan family, were referred to our clinic for diagnostic workup and candidacy selection for cochlear implantation (CI). Methods: Molecular analysis showed a homozygous c.1342C > T p. (Arg448*) pathogenic variant in exon 7 of the TRIOBP gene (reference sequence NM_001039141.2) in all 3 affected siblings. Clinical audiometry demonstrated profound sensorineural hearing loss in all 3 affected siblings (2 males and 1 female), and they were implanted unilaterally. Results: One month after activation, the pure-tone averages with the CI processor were between 30 and 23 dBHL. Ten months after the first activation of the implant, open-set speech audiometry test could be performed for the first time in the 2 younger CI recipients (S5 and S9), and they could identify up to a maximum 77% phonemes correctly. The oldest brother (S12) could not yet perform open-set speech audiometry at that moment. Conclusions: Implant outcomes are better with normal inner ear anatomy in general. The earlier congenital patients are implanted, the better their outcomes. Here, we demonstrate both statements are true in a homozygous c.1342C > T p. (Arg448*) pathogenic variant in the TRIOBP gene in all 3 affected siblings.Öğe Comparison of fiber delivered CO2 laser and electrocautery in transoral robot assisted tongue base surgery(Springer, 2017) Karaman, Murat; Gün, Taylan; Temelkuran, Burak; Aynacı, Engin; Kaya, Cem; Tekin, Ahmet MahmutTo compare intra-operative and post-operative effectiveness of fiber delivered CO2 laser to monopolar electrocautery in robot assisted tongue base surgery. Prospective non-randomized clinical study. Twenty moderate to severe obstructive sleep apnea (OSA) patients, non-compliant with Continuous Positive Airway Pressure (CPAP), underwent Transoral Robotic Surgery (TORS) using the Da Vinci surgical robot in our University Hospital. OSA was treated with monopolar electrocautery in 10 patients, and with flexible CO2 laser fiber in another 10 patients. The following parameters in the two sets are analyzed: Intraoperative bleeding that required cauterization, robot operating time, need for tracheotomy, postoperative self-limiting bleeding, length of hospitalization, duration until start of oral intake, pre-operative and post-operative minimum arterial oxygen saturation, pre-operative and post-operative Epworth Sleepiness Scale score, postoperative airway complication and postoperative pain. Mean follow-up was 12 months. None of the patients required tracheotomy and there were no intraoperative complications related to the use of the robot or the CO2 laser. The use of CO2 laser in TORS-assisted tongue base surgery resulted in less intraoperative bleeding that required cauterization, shorter robot operating time, shorter length of hospitalization, shorter duration until start of oral intake and less postoperative pain, when compared to electrocautery. Postoperative apnea-hypopnea index scores showed better efficacy of CO2 laser than electrocautery. Comparison of postoperative airway complication rates and Epworth sleepiness scale scores were found to be statistically insignificant between the two groups. The use of CO2 laser in robot assisted tongue base surgery has various intraoperative and post-operative advantages when compared to monopolar electrocautery.Öğe Content analysis of the top 25 most cited articles of the journal of craniofacial surgery with chatgpt-4o(2025) Durna, Yusuf Muhammed; Tekin, Mustafa Said; Duymaz, Yaşar Kemal; Tekin, Ahmet Mahmut; Bahşi, İlhanObjective:Since 1990, the Journal of Craniofacial Surgery has been an important resource for clinicians and basic scientists. The journal addresses clinical practice, surgical innovations, and educational issues. This study aims to evaluate the contribution of these articles to clinical practice innovations and surgical procedures by analyzing the content of the 25 most cited articles published in the journal. It also aims to demonstrate the potential of artificial intelligence tools in academic content analysis.Methods:All articles published in the Journal of Craniofacial Surgery on June 13, 2024, were searched using the Web of Science Database, and the 25 most cited articles were identified. The full texts of these articles were saved in PDF format and metadata were saved as plain text files. Content analysis of these 25 articles was performed using ChatGPT-4o.Results:As a result of the analysis, some articles stood out in terms of clinical importance. It also appeared that ChatGPT could be used to compare multiple articles.Conclusion:In this study, the authors analyzed the content of the 25 most cited articles published in the Journal of Craniofacial Surgery using ChatGPT-4o. These articles were evaluated according to the criteria of innovations in clinical practice and compliance with surgical procedures. This study presents interesting findings in terms of the use of artificial intelligence tools in academic content analysis. The authors thought that this study could be a source of inspiration for future studies.Öğe Effect of piezoelectric technique on auditory function on postoperative day one in septorhinoplasty surgery(Lippincott Williams & Wilkins, 2018) İlhan, Adem Emre; Durna, Yusuf Muhammed; Tekin, Ahmet Mahmut; Yılmaz, Fahrettin; Yılmaz, Yetkin ZekiAim: To examine the effect of the piezoelectric application used increasingly for osteotomy and correction of nasal dorsum in septorhinoplasty surgeries on early auditory functions. Methods: Our study was conducted after the decision of 10840098604.01.01- E. 9057 taken from Istanbul Medipol University Clinical Research Local Ethics Committee. This study was designed to be prospective, randomized and controlled. Twenty patients between 18 and 50 years of age that piezoelectric technique was used in the study group and 10 patients in the same age range who underwent nasal surgery (endoscopic sinus surgery, septoplasty, lower concha radiofrequency and nasal valve surgery) for any reason in the control group were included in the study. Audiologic functions of the patients in both the groups were assessed by pure audio audiometry, tympanometry and distortion product otoacoustic emission test before the surgery and 24 hours after the surgery. The data obtained were statistically compared using the SPSS 22.0 program and P<0.05 was considered significant. Results: Twenty patients (5 males, 15 females) that piezoelectric (ultrasonics) technique was used during septorhinoplasty in the study group and 10 patients (5 males, 5 females) in the control group were included in the study. In the study and the control groups, preoperative and postoperative air/bone path thresholds at the right and left ears did not differ significantly (P>0.05) at 250, 500, 1000, 2000, 4000, 6000, and 8000Hz. The results of distortion product otoacoustic emission results (signal/noise ratio) obtained postoperativelywere not statistically significant (P>0.05) with the results obtained preoperatively. Conclusion: The results of the study show that the piezoelectric technique used in septorhinoplasty does not cause a negative effect on auditory functions. This study is the first comparative study to investigate the effect of piezoelectric technique used in septorhinoplasty surgery on auditory functions. After further clinical studies performed with well- selected and large patient population, the piezoelectric techniques can be a preferred technique during septorhinoplasty operations.Öğe Effects of rhinoplasty on labyrinthine function(Oxford University Press Inc, 2018) Tekin, Ahmet Mahmut; Soylu, Erkan; Turan Dizdar, Handan; Yılmaz, Fahrettin; Bayazıt, Yıldırım AhmetBackground: Rhinoplasty is a common surgical procedure that is requested and accepted by patients for cosmetic and functional reasons. Osteotomies are performed on nasal bone, maxillary crest, or vomer to fix the deviations of the nasal dorsum or septum. During the percussion of the osteotomes with the surgical mallet, the vibration energy diffuses to the cranium. Auditory and vestibular systems may be affected by these vibrations. Objectives: To assess the effects of rhinoplasty, in which osteotomies were performed using a hammer, on the audiovestibular system. Methods: Thirty adults who underwent rhinoplasty were included in the study group. Ten age and gender matched adults who had nasal surgery without surgical mallet or osteotome served as the control group. The patients in both groups were assessed using pure tone audiometry, tympanometry, distortion product otoacoustic emission testing, and vestibular-evoked myogenic potential, as well as video head impulse tests (vHIT) before the operation and 1 week after the operation. Results: On auditory assessment, there was no significant difference between the study and control groups regarding pure tone thresholds at frequencies of 250Hz to 8 kHz (P> 0.05) as well as otoacoustic emissions. The vestibular assessment performed by using vestibular-evoked myogenic potential and vHIT did not reveal a statistically significant difference between the groups, before surgery or after surgery (P> 0.05). Conclusions: Rhinoplasty appears to be a safe operation in terms of audiovestibular functions, and osteotomy, in which a hammer is usually used, does not have an impact on hearing or balance functions of the ear.Öğe Evaluation of a less invasive cochlear implant surgery in OPA1 mutations provoking deafblindness(NLM (Medline), 2023) Tekin, Ahmet Mahmut; Baelen, Hermine; Heuninck, Emilie; Bayazıt, Yıldırım Ahmet; Mertens, Griet; Rompaey, Vincent van; Heyning, Paul van de; Topsakal, VedatCochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires revision surgery every 20 to 25 years, and thus placement should be minimally invasive. Furthermore, failed reimplantation surgery will have more impact on a deafblind person. In this context, we assessed the safety of minimally invasive robotically assisted cochlear implant surgery (RACIS) for the first time in a deafblind patient. Standard pure tone audiometry and speech audiometry were performed in a patient with deafblindness as part of this robotic-assisted CI study before and after surgery. This patient, with an optic atrophy 1 (OPA1) (OMIM#165500) mutation consented to RACIS for the second (contralateral) CI. The applicability and safety of RACIS were evaluated as well as her subjective opinion on her disability. RACIS was uneventful with successful surgical and auditory outcomes in this case of deafblindness due to the OPA1 mutation. RACIS appears to be a safe and beneficial intervention to increase communication skills in the cases of deafblindness due to an OPA1 mutation. The use of RACIS use should be widespread in deafblindness as it minimizes surgical trauma and possible failures.Öğe Evaluation of sexual functions in patients with chronic suppurative otitis media(Istanbul University Press, 2018) Çalım, Ömer Faruk; Altın, Gökhan; Güzelburç, Vahit; Yılmazer, Rasim; Keleş, Ahmet; Tekin, Ahmet Mahmut; Soylu, ErkanObjectives: The aim of this study is to evaluate sexual function scores in patients with chronic suppurative otitis media.Patients and Methods: A total of 35 patients (20 male, 15 female) who had purulent discharge in one or both ears for at least threemonths and were diagnosed with chronic otitis media were included in the study group, while 30 volunteers (15 males, 15 females)who had no problem with their ears were included in the control group. Patients and controls underwent otolaryngology and urologyexaminations; female participants were asked to fill the female sexual function index and male participants were asked to accomplishthe international index of erectile function. Pure tone audiometry, tympanometry and speech discrimination tests were applied on allparticipants.Results: A significant difference was found between patients and controls in terms of scores for the subscales sexual desire(p=0.044), erectile function (p=0.012), and overall satisfaction (p=0.002) of the international index of erectile function in males.No significant difference was found between both groups in terms of other subscale scores (p>0.05). A significant difference wasfound (p<0.05) between patients and controls in terms of scores for the subscales orgasm (p=0.004), satisfaction (p=0.007), desire(p=0.020), arousal (p=0.002), and lubrication (p=0.015) in the female sexual function index. No significant difference was found(p>0.05) between both groups only in the subscale pain (p=0.450).Conclusion: Chronic otitis media also negatively affected sexual function scores and it should also be examined from this aspect.Öğe Evaluation of the postoperative cutaneous findings in rhinoplasty patients(2017) Üstüner, Pelin; Tekin, Ahmet Mahmut; Soylu, ErkanAim: This study aimed to evaluate the post—operative presence, clinical severity and course of acne vulgaris and seborrheic dermatitis among rhinoplasty patients. Material and Method: Fifty-six patients who were planned to have rhinoplasty were administered either pored or non-pored plaster cast for one week in the postoperative period.The patients in the rhinoplasty group were randomizedinto four groups according to the application of pored or nonpored plaster cast and adhesive strips for further one-week. Forty patients that had undergone closed technique-septoplasty were included in the control group. The self-assessments of the patients in the rhinoplasty and septoplasty groups were recorded in terms of acne,seborrhea and erythema via visual analog scale (VAS). The clinical severity of acne vulgaris andseborrheic dermatitis were compared via Global Acne Grading Score (GAGS) and Seborrheic Dermatitis Area and Severity Index (SDASI) in both groupsat postoperative months 1, and 6. Results: In the rhinoplasty group, the VAS acne, VAS seborrhea, VAS erythema, GAGS, and SDASI values increased significantly at postoperative month and decreased significantly at postoperative month compared to the pre-operative values. At all visits, the GAGS values of patients that had undergone rhinoplasty were found statistically significantly higher than those that had received septoplasty. At postoperative month 6, the GAGS values were significantly decreased in the group treated with non-pored plaster cast and adhesive strips for one more week. The SDASI values statistically significantly decreased only in the group treated with pored plaster cast. However, at all visits, the mean values of GAGS and SDASI were similar in the four rhinoplasty groups according to the different types of plaster cast duration of nasal bandages. Conclusion: We concluded that in post-rhinoplasty patients, the plaster cast type and duration of nasal bandage application do not affect the severity of acne vulgaris and seborrheic dermatitis.Öğe Global research on hereditary hearing impairment over the last 40 years: A bibliometric study(Aves, 2021) Tekin, Ahmet Mahmut; Bahşi, İlhan; Bayazıt, Yıldırım Ahmet; Topsakal, VedatBACKGROUND: Research on hereditary hearing impairment has had several boosts to identify deafness-causing genes. The number of studies regarding the diagnosis and treatment modalities of hereditary hearing impairment is enormous and increasing; however, little or no research has been conducted for evaluating the development of scientific output and trends in the field. Here, we provide a comprehensive overview of centers that focus their research on hereditary hearing impairment and their scientific output. METHODS: Bibliometric analysis of the publications related to hereditary hearing impairment published between 1980 and 2019 were used in this study, which were also indexed in Web of Science database. RESULTS: The highest number of scientific articles on hereditary hearing impairment came from the United States, and it was also the most cited country. The University of Iowa is a leading center in the domain of hereditary hearing impairment in the world over the last 40 years. Fudan University, Central South University, and Harvard Medical School are also institutions that have had a focus on hereditary hearing impairment. CONCLUSIONS: There is a progressive increase in scientific papers on hereditary hearing impairment over the last 40 years that we have found in our bibliometric study. We identified key centers in the scientific research on hereditary hearing impairment in the world and also key journals that focus on hereditary hearing impairment. This information can facilitate new researchers in this field to seek collaboration with experienced partners, better synthesize the orientation and boundaries of the subject, and find target journals. Ultimately, we provided a certain benchmark value for key centers that perhaps should have a more prominent role in constructing experimental research or even clinical guidelines.Öğe Multiple metastatic giant cell carcinoma ex pleomorphic adenoma leading to respiratory failure in the head and neck region(2016) Yılmaz, Fahrettin; Altın, Gökhan; Tekin, Ahmet Mahmut; Türkmen, İlknur; Çakır, AslıCarcinoma ex pleomorphic adenoma is a rare tumor that results from the carcinomatous transformation of a primer or recurrent pleomorphic adenoma. A 75-year-old male patient presented with a solid mass in his neck and respiratory failure. The patient had a 20-year history of this disease. A clinical examination revealed a solid and fixed mass with a number of lobules that fully pervaded the 2nd region on the left side of the neck, arising from the left parotid. Facial nerve functions were good. Furthermore, solid and mobile masses were identified in the frontal region, below the scalp, in the auricle of the left ear and the in left superficial layer of the sternocleidomastoid muscle. An oropharynx examination revealed that the left tonsil region had passed to the midline of the neck, pushing the uvula under the effect of the mass. In an MRI of the neck, the image involved the masticatory and parapharyngeal area that filled in the left parotid on the skull base, narrowed the Rosenmuller fossa on the left superior and obliterated significantly the air lumen on the oropharynx level. The mass extended to the hyoid bone in the caudal and to the bottom of skinto-skin in parotid region. The measurable size of the mass was 9 x 10 cm. The patient underwent a total parotidectomy and a left neck dissection in surgery, and in addition, other masses in the neck and the head were excised.Öğe Recovery of tinnitus and sensorineural hearing loss due to lysis of arachnoid adhesions in the posterior cranial fossa: Is there a novel etiology in neurotological disorders?(Aves, 2017) Cevizci, Raşit; Dilci, Alper; Tekin, Ahmet Mahmut; Bayazıt, YıldırımWe reported the recovery of sensorineural hearing loss and tinnitus in a 22-year-old man after complete removal of intracranial portion of jugular foramen schwannoma via the retrosigmoid approach. The aim of this case report was to present the excision of a large jugular foramen schwannoma via the retrosigmoid approach and to describe the improvement of sensorineural hearing loss related to arachnoid inflammations due to chronic arachnoiditis after suboccipital craniectomy. The recovery of sensorineural hearing loss and tinnitus after release of arachnoid adhesions may indicate the clinical significance of these adhesions or arachnoiditis, which should also be considered and investigated in the etiology of other neurotological diseases.Öğe Sensorineural hearing loss in the opposite ear following head trauma(2016) Tekin, Ahmet Mahmut; Soylu, Erkan; Altın, Gökhan; Yılmaz, Fahrettin; Haberal Can, İlknurSensorineural hearing loss following the head traumais one of the most common complications that mightoccur. Although radiological evidence that presents thelabyrinth damage as sensorineural hearing loss in somepatients complaining of these symptoms after thetrauma; cannot be determined. The underlyingmechanism is commonly assumed to be the concussionof the labyrinth that is frequently seen in headtraumas. In this paper, we would like to presentdouble?sided tinnitus and hearing loss that developedafter the head trauma due to the concussion of thelabyrinth in the opposite ear without temporal bonefractures.
