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Öğe Determination and evaluation of acidity constants of some imidazole and thiazole linked acetamide compounds(Anadolu University, 2016) Tay, Naime Funda; Duran, Murat; İspir, Cihan; Demirayak, ŞerefIn this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric method. When the molecules possessed different substituents the values of the acidity constants changed from 6.01 to 8.22 for the first protonation and from 3.07 to 4.73 for the second protonation. The first protonation under these circumstances was observed to occur on the nitrogen atom of the 2-mercaptoimidazole ring. The second protonation was observed to occur on the nitrogen atom of the thiazole ring.Öğe Synthesis of some N-[4-(benzothiazole-2yl)phenyl]-2-aryloxyacetamide derivatives and their anticancer activities(Informa Healtcare, 2012) Tay, Naime Funda; Yurttaş, Leyla; Demirayak, ŞerefIn this study, some N-[4-(Benzothiazole-2-yl)phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2-chloroacetamide and different substituent phenol or thiophenol derivatives. The anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, namely 25 and 38, showed notable anticancer activity.Öğe Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds(Walter de Gruyter GmbH, 2022) Tay, Naime Funda; Berk, Barkın; Duran, Murat; Kayagil, İsmail; Yurttaş, Leyla; Biltekin Kaleli, Sevde Nur; Yamaç, Mustafa; Karaduman, Ayşe Betül; Demirayak, ŞerefIn this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were screened with a panel of gram positive/negative bacteria, yeasts, and molds for antimicrobial activity using the disc diffusion method. Then, the minimum inhibitor concentration (MIC) and the minimum bactericidal concentration (MBC) values of active compounds were determined against Micrococcus luteus, Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus using the broth microdilution technique. These compounds were also screened for their inhibitory activities against S. aureus DNA gyrase by supercoiling assay. Furthermore, the crystal structure of S. aureus DNA gyrase B ATPase was subjected to a docking experiment to identify the possible interactions between the most active ligand and the active site. Lastly, the in silico technique was performed to analyze and predict the drug-likeness, molecular and ADME properties of the synthesized molecules.Öğe Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives(Universidade de São Paulo, 2022) Tay, Naime Funda; Duran, Murat; Kayagil, İsmail; Yurttaş, Leyla; Göger, Gamze; Göğer, Fatih; Demirci, Fatih; Demirayak, ŞerefIn this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.Öğe Synthesis, structure elucidation and determination of acid dissociation constant, tautomerism of pyrido [1,2-a] benzimidazole-2,4-dione(University of Istanbul, 2016) Kayağil, İsmail; Tay, Naime Funda; Konak, Hüseyin Yaşar; İspir, Cihan; Demirayak, ŞerefThe first starting material, 1H-2-acetylbenzimidazole, 4, was synthesized by o-phenylenediamine, 1, and lactic acid solution, 2, in hydrochloric acid medium on the first step than, oxidation reaction was performed by CrO3 in acetic acid medium on the second step. The last starting material, ethyl 2-(2-acetylbenzimidazol-1-yl) acetate, 6, was synthesized by using first starting material, 4, ethyl 2-bromoacetate, 5, and K2 CO3 in acetone medium. The target compound, pyrido[1,2-a] benzimidazole-2,4-dione, 7, was synthesized by using the last starting material, 5, in sodium ethoxide medium. The compound, 7, can be found in two forms which are keto and enol which would be evaluated in this study. For the evaluation, it was performed some spectroscopic studies. In addition, it was evaluated experimentally obtained acidity constant, pKa value and tautomeric equilibrium of the compound, 7, by using ultraviolet-visible (UV-Vis) spectrophotometer. All of these studies have shown that the valid form of the compound, 7, is keto form.
