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  • Küçük Resim
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    Gastric cancer prevention from the point of helicobacter
    (AVES, 2014) Balaban, Yasemin Hatice; Şimşek, Halis; Tatar, Gonca
    When the first cancer estimates of world were made in 1975, gastric cancer (GC) was the most common neoplasm, making 70% of the total. Although its rate decreased to 6.8% in 2012, it is still the fifth most common malignancy after cancers of the lung, breast, colo-rectum, and prostate and the third leading cause of cancer death in both sexes worldwide (8.8%, 723,000 deaths) (1). Proximal (cardia) and distal (non-cardia) gastric adenocarcinomas have different epidemiological and clinical features. Although there is an increase in proximal GCs, most of the GCs are still distally located, and intestinal-type. H. pylori is an established trigger of gastric carcinogenesis; reversibility of precancerous conditions, including intestinal metaplasia (IM), after eradication treatment is a hot topic for research. Therefore, we read with great interest the study by Galiatsatos P et al. (2) on the sensitivity of gastric biopsy for H. pylori detection in the presence of IM. The data have once again emphasized the importance of using non-invasive tests and histopathology together in the presence of gastric IM.
  • Küçük Resim
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    Iron overload and insulin resistance in a sample of Turkish patients with non-alcoholic steatohepatitis
    (Galenos Yayınevi, 2015) Gökcan, Hale; H. Balaban, Yasemin; Şimşek, Halis; Yılmaz, Engin; Gedikoğlu, Gökhan; Hasçelik, Gülşen; Tatar, Gonca
    Aim: We investigated the role ofthe H63D mutation on the development of hepatic iron overload and hepatic injury in non-alcoholic Steatohepatitis patients and its association with insulin resistance and metabolic alterations. Material and Methods: Thirty-two patients with NASH, who were diagnosed at Hacettepe University Gastroenterology Outpatient Clinic depending on clinic and laboratory findings, were included into study. Metabolic syndrome was sought. Waist hip ratio and body mass index were calculated. H63D gene mutation, iron level at serum and liver biopsy specimens and histopathologic exam on liver biopsy specimens were studied in study group. Fasting and post-prandial blood sugar, lipid profile, 75-gr-glucose tolerance test and HOMA insulin resistance were measured to document the insulin resistance and metabolic syndrome. Results: Thirty-two patients with mean body mass index was 28.1 kg/m2i3,3 were included in study. Hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, insulin resistance were found at 25 %, 37 %, 56 %, 28 and 39 %, respectively. Serum ferritin and transferrin saturation values were within normal limits in all but except patients. Hepatic iron concentration was 1600ug in 12 (41%) of patients. H63D mutation was homozygote in (3%) and heterozygote 12 (40%) patients. Therefore the H63D allele frequencies were 3.3% for homozygous, 20% for heterozygous and as total 23.4%. The patients with H63D mutation had normal serum and tissue iron parameters. There was no statistically significant relationship between H63D mutation and histopathological findings. Two hour blood sugar levels were higher in Stage patients than in Stage patients (p=0.05), and also higher in Class patients than in Class S3 patients (p=0.05). Conclusion: The H63D mutation did not affected either serum iron parameters or histopathology. However, the insulin resistance was related with fibrosis in non-alcoholic steatohepatitis patients.