Yazar "Taoufik, Yassine" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    B cells and progressive multifocal leukoencephalopathy: Search for the missing link
    (Frontiers Media, 2015) Durali, Deniz; de Herve, Marie-Ghislaine de Goer; Gasnault, Jacques; Taoufik, Yassine; Lovett-Racke, Amy
    Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe immunodepression, and cases have recently been linked to therapeutic monoclonal antibodies such as natalizumab and also rituximab, which depletes B cells. B cells appear to play a complex role in the pathogenesis of PML. They may act as a viral reservoir and as a vector for viral dissemination in the central nervous system. Anti-JCV antibody responses appear to have a limited effect on JCV replication in the brain. However, accumulating evidence suggests that B cells may considerably influence T cell responses through their cytokine secretion. This immunomodulatory function of B cells may play an important role in the control of JCV infection and in the pathogenesis of PML, including rituximab-induced PML.
  • Küçük Resim
    Öğe
    Follicular CD4 T cells tutor CD8 early memory precursors: An initiatory journey to the frontier of B cell territory
    (Cell Press, 2019) de Herve, Marie-Ghislaine de Goer; Abdoh, Maisa; Jaafoura, Salma; Duralı, Deniz; Taoufik, Yassine
    The early events of CD8 memory generation remain largely unknown. Here we report that as early as 2 days after antigen priming, very earlymemory precursors can be identified by their expression of the chemokine receptor CXCR5. These early precursors, which have an effector phenotype, expand and temporarily migrate to the T-B cell zone junction where they interact with follicular CD4(+) T cells (Tfh). Remarkably, this interaction with Tfh, hitherto considered as exclusive B cell helpers, is required for CD8 memory precursors to become highly competent memory cells. CD40 and interleukin-21 signaling are involved in the help provided to CXCR5(+)CD8memory precursors. This study thus unveils critical early steps in the generation of CD8memory, identifies CXCR5 as the earliest known marker of CD8 memory precursors, suggests a major helper role for Tfh, and points to possible coordination between the pathways of CD8 and B cell memory generation at the T-B-cell zone junction.