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Öğe Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats(Brazilian Society of Urology, 2015) Ötünçtemur, Alper; Özbek, Emin; Çakır, Süleyman Sami; Dursun, Murat; Çekmen, Mustafa Baki; Polat, Emre Can; Özcan, Levent; Somay, Adnan; Özel Özbay, NurverIntroduction: Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats. Materials and Methods: 32 rats divided four groups. Group 1 was control, group 2 was sham, group 3 was rats with UUO and group 4 was rats with UUO which were given montelukast sodium (oral 10 mg/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide(NO), malondialdehyde(MDA) and reduced glutathione(GSH) levels were determined in the other part of kidneys. Urea-creatinine levels were investigated at blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA). Results: There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing for tubular necrosis and fibrosis in group 4(p<0.005). Also, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in group 3 compared the other groups(p<0.005). Conclusion: We can say that montelukast prevent kidney damage with antioxidant effect, independently of NO.Öğe Pomegranate extract attenuates unilateral ureteral obstruction-induced renal damage by reducing oxidative stress(Medknow Publications, 2015) Ötünçtemur, Alper; Özbek, Emin; Çakır, Süleyman Sami; Polat, Emre Can; Dursun, Murat; Çekmen, Mustafa Baki; Somay, Adnan; Özel Özbay, NurverAims: Ureteral obstruction may cause permanent kidney damage at late period. We know that the pomegranate extract (PE) play a strong role on removal of free oxygen radicals and prevention of oxidative stress. In the current study study, we evaluated the effect of PE on kidney damage after unilateral ureteral obstruction (UUO). Settings and Design: A total of 32 rats were divided into four groups. Group 1 was a control, Group 2 was a sham, Group 3 was rats with UUO and Group 4 was rats with UUO that were given PE (oral 100 L/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Subjects and Methods: Tubular necrosis, mononuclear cell infiltration, and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide (NO), malondialdehyde (MDA), and reduced glutathione (GSH) levels were determined in the other part of kidneys. Statistical Analysis Used: Statistical analyses were performed by the Chi-square test and one-way analysis of variance. Results: There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis, mononuclear cell infiltration and fibrosis in Group 3, and there was significantly decreasing for tubular necrosis, mononuclear cell infiltration and fibrosis in Group 4 (P < 0.005). Furthermore, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in Group 3 compared the other groups (P < 0.005). Conclusions: We think that the PE prevents kidney damage by decreasing oxidative stress in kidney.Öğe Relationship between histopathological features of aspirated thrombi and long-term left ventricular function in patients with ST-segment elevation myocardial infarction(Turkish Society of Cardiology, 2020) Omaygenç, Mehmet Onur; Doğan, Cem; Somay, Adnan; Karaca, Oğuz; Bakal, Ruken Bengi; Teber, Mehmet Kamil; Hatipoğlu, Suzan; Bayram, Zübeyde; Kaymaz, Cihangir; Özdemir, NihalObjective: This study was an investigation of the severity ofinflammation (SOI) in aspirated material and thrombus age toexamine any association with pre-discharge and long-term leftventricular (LV) function after ST-elevation myocardial infarction (STEMI).Methods: The study group comprised 25 patients with STEMIfrom whom an occlusive thrombus was aspirated from the infarct-related artery with a 7-F catheter. The SOI in the aspirate was determined according to the mean leukocyte countin 5 high-power magnification fields and graded as mild in thepresence of ?100 leukocytes per field or significant if therewere >100 leukocytes per field. The thrombi were categorizedas fresh or lytic/organized (L/O) using predefined criteria.Echocardiographic assessment was performed prior to discharge and at 1 year. Adverse left ventricular remodeling (LVR)was defined as a 20% increase in LV end-diastolic volume incomparison with baseline values.Results: LVR was observed in 8 patients. The mean leukocytecount of the aspirate (127.5±86.0 vs 227.2±120.7; p=0.026)and frequency of significant inflammation (35% vs 75%;p=0.046) were significantly higher in the group with LVR. Theserum high-sensitivity C-reactive protein (hsCRP) level wassignificantly correlated with the leukocyte count of the aspirate (r=0.532; p=0.006). An L/O thrombus was related to betterpre-discharge and long-term LV volumes and ejection fractionvalues compared with a fresh thrombus.Conclusion: A significant increase in the leukocyte count inthe aspirate and a fresh thrombus might predict long-term LVfunctional deterioration irrespective of the clinical and procedure-related characteristics. In addition, serum markers of inflammation, like hsCRP, might also reflect the intensity of thelocal inflammatory response at the site of occlusion.Öğe The comparison of GLUT-4 and nNOS expression in diabetic and non-diabetic patients with BPH/LUTS(Springer, 2015) Ötünçtemur, Alper; Beşiroğlu, Hüseyin; Dursun, Murat; Özcan, Levent; Polat, Emre Can; Somay, Adnan; Özbay, Nurver; Özer, Kutan; Özbek, EminThe aim of this study was to compare glucose transporter-4 (GLUT-4) and neuronal nitric oxide synthase (nNOS) expression in diabetic and non-diabetic patients who underwent TUR-P or transvesical prostatectomy with the diagnosis of BPH. Thirty diabetic patients with an average age of 58 and 30 non-diabetic patients with that of 56 were included in the study. T-PSA, IPSS, Q max value and prostate volume were compared between the two groups. The stromal and glandular staining scores of GLUT-4 and nNOS expression were compared. Student's t test and Mann-Whitney U test were used for statistical analysis. There was no statistically significant difference in terms of age, IPSS, Qmax and PSA. Patients with diabetes had larger prostate volumes (p = 0.02). Mean GLUT-4 glandular total scores in diabetic and non-diabetic patients were 3.36 +/- A 1.21 and 2.1 +/- A 1.39, respectively, whereas stromal total scores were 3.63 +/- A 1.12 and 2.46 +/- A 1.33, and they were both statistically significant (p = 0.028 and p = 0.032, respectively). Glandular total nNOS scores in diabetic and non-diabetic patients were 4.53 +/- A 1.0 and 2.80 +/- A 1.12, while stromal total scores were 1.76 +/- A 1,0 and 2.30 +/- A 1.08 and they were found to be statistically significant (p = 0.0001 and p = 0.037, respectively). GLUT-4 expression was found higher in prostatic tissue of the patients with diabetes mellitus. The expression value of nNOS was higher in the glandular area in diabetic patients, while stromal area expression score was higher in non-diabetic patients. Although our findings indicate important results, carefully designed further studies are needed to better comprehend the role of GLUT-4 and NOS pathways in BPH/LUTS pathophysiology.
