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Öğe A novel biochemical marker for community-acquired pneumonia: Ischemia-modified albumin(W.B. Saunders, 2017) Bolatkale, Mustafa; Düger, Mustafa; Ülfer, Gözde; Can, Çağdaş; Acara, Ahmet Çağdaş; Yiğitbaşı, Türkan; Seyhan, Ekrem Cengiz; Bulut, MehtapIntroduction Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and a leading cause of mortality worldwide. Early diagnosis and the initiation of appropriate antibiotic therapy are essential to reduce pneumonia-related morbidity and mortality. CRP is a well-established biomarker in many clinical settings, but has been traditionally considered not specific enough to be a useful guide in the diagnostic process of pneumonia. There is still a need for more specific and practical markers in CAP for diagnosis. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) levels in the diagnosis of CAP in the Emergency Department. Methods The study included 81 patients admitted with CAP and 81 control patients. Initial hour levels of IMA and CRP were measured. The IMA mean levels were compared between the study and control group. Correlation analyses were performed to investigate the association of serum IMA levels with CRP. Results Mean levels of IMA were 0.532 ± 0.117 IU/ml in the study group and 0.345 ± 0.082 IU/ml in the control group. IMA levels were significantly higher in the study group compared to the control group. The IMA level of 0.442 IU/ml had sensitivity of 75.3% and specificity of 91.3% and was positively correlated with CRP levels (r = 0.506; p < 0.05). Conclusion Blood IMA levels significantly increase in adult patients presenting with CAP. IMA may be considered as a novel biomarker in the diagnosis of CAP.Öğe Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy?(Taylor & Francis, 2015) Önür, Seda Tural; Sökücü, Sinem Nedime; Dalar, Levent; Seyhan, Ekrem Cengiz; Akbaş, Ayşegül; Altın, SedatBackground: The differential diagnostic utilities of the levels of soluble interleukin (IL)-12p40 and the IL-2 receptor in sera and pleural effusions were evaluated in patients with exudative pleural effusions. Methods: We enrolled a total of 120 patients with exudative pleural effusions. The clinical, radiological, and histopathological diagnoses were tuberculous pleurisy in 52, malignant pleurisy in 39, and parapneumonic effusions in 29 patients. Results: We measured serum IL-12p40 and adenosine deaminase (ADA) levels in patients with tuberculous pleurisy and in a control group treated for pleural effusion to determine if such levels were useful in the diagnosis of pleural effusion (p < 0.005). Definite microbiological or histopathological diagnoses of tuberculous pleurisy or pleural effusion were recorded, and we found that ADA and serum soluble IL-2 receptor levels aided in diagnosis (p < 0.001). The levels of ADA and soluble IL-2 in pleural effusions afforded sensitivities and specificities of 84.62% and 82.69% and of 70.59% and 80.88%, respectively. The soluble IL-2 receptor level afforded a sensitivity and specificity of 82.69% and 52.9%. IL-12p40 levels in pleural effusions and sera afforded sensitivities and specifi cities of 80.77% and 80.77% and of 60.29% and 39.71%, respectively. Conclusion: Soluble IL-2 receptor levels in patients with tuberculous pleurisy serve as markers of disease in non-endemic countries, similarly to ADA levels.Öğe Bronchoscopic management of endobronchial lipoma: A case report(Bayçınar Medical Publishing, 2016) Seyhan, Ekrem Cengiz; Özgül, Mehmet Akif; Çetinkaya, Erdoğan; Günlüoğlu, Zeki; Özgül, Güler; Cebeci, GökhanEndobronchial lipomas are very rare tumors. Although surgery may be required in some cases, bronchoscopic removal is the preferred treatment modality. In this article, we present a case of endobronchial lipoma incidentally found after excision of a giant esophagus diverticulum. During follow-up of the patient, a tumor, located in the right lower lobe bronchus, was seen at thorax computed tomography. The tumor was excised via rigid bronchoscopy. This case highlights the effectiveness of rigid bronchoscopy in the management of endobronchial tumors.Öğe Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients(J-Stage, 2015) Günlüoğlu, Gülşah; Seyhan, Ekrem Cengiz; Kazancıoğlu, Rumeyza; Günlüoğlu, Zeki; Şimşek Veske, Nurdan; Ertan Yazar, Esra; Altın, SedatObjective Patients undergoing haemodialysis for chronic renal failure-hemodialysis (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. Methods The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using QuantiFERON-TB Gold In Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. Results TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (kappa=1). Conclusion Blood IP-10 level, which can be measured simply, provides results equivalent to IGRAs for the diagnosis of LTBI in CRF-HD patients.Öğe Diagnostic value and safety of medical thoracoscopy in the management of exudative pleural effusion(Turkish Respiratory Soc, 2016) Özgül, Mehmet Akif; Çetinkaya, Erdoğan; Tanrıverdi, Elif; Çotuk, Mustafa; Acat, Murat; Gül, Şule; Seyhan, Ekrem Cengiz; Omaygenç, Derya Özden; Akın, Hasan; Abbaslı, Kenan; Onaran, HilalObjective: Medical thoracoscopy is a minimally invasive procedure that is performed by experienced pulmonologists under local anesthesia and conscious intravenous sedation. It allows direct observation and evaluation of the pleural space. Our aim is to evaluate the diagnostic efficacy and safety of this procedure while presenting our results of medical thoracoscopy performed by rigid thoracoscopy in our clinic. Methods: Thirty-seven patients who had gone thorough medical thoracoscopy between March 2011 and August 2014 were evaluated retrospectively. Results: Of these 37 patients, 26 were male and the average age was 50.94 +/- 15.38 years. Fourteen patients had right-sided pleural effusion, whereas 23 had left-sided pleural effusion. Closed pleural biopsy was performed previously in 16 patients with no diagnostic results. In 36 patients (97.3%), a specific diagnosis was achieved. One patient, diagnosed as lymphocytic pleuritis by medical thoracoscopy, underwent decortication and the pathology was consistent with biphasic malignant pleural mesothelioma. Another patient, diagnosed as chronic nonspecific pleuritis with medical thoracoscopy, underwent decortication and the diagnosis was fibrinous pleuritis characterized by extensive fibrosis. Three patients had expansion defects during the post-operative period. Hemothorax occurred in one patient that died of respiratory failure on day 34 of hospitalization. The median length of stay in the hospital after the procedure was 5 days (1-34). Conclusion: Medical thoracoscopy is a secure procedure with high diagnostic value in the management of exudative pleural effusion.Öğe Does ischemia-modified albumin level predict severity of obstructive sleep apnea?(Springer, 2021) Düger, Mustafa; Seyhan, Ekrem Cengiz; Günlüoğlu, Mehmet Zeki; Bolatkale, Mustafa; Özgül, Mehmet Akif; Turan, Demet; Uğur, Efsun; Ülfer, GözdeObjective and aim Ischemia-modified albumin (IMA) is a newly recognized marker of chronic inflammation used to evaluate oxidative stress status in patients with various diseases. We explored the possible relationship between IMA levels and obstructive sleep apnea (OSA). Methods In this retrospective study, 169 of 216 sequential patients being evaluated for suspicion of OSAS met inclusion criteria. Polysomnography confirmed OSA in 86 patients (51%) while 81 patients (49%) without OSA were categorized as control subjects. All study participants were tested for blood IMA level, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) level, and red blood cell distribution width (RDW). Results The serum IMA level was significantly higher in patients with OSAS than controls (p = 0.008). The serum IMA level increased significantly as OSAS severity increased (r = 0.50, p < 0.001) and was positively correlated with the AHI (r = 0.41, p < 0.001), CRP level (r = 0.31, p = 0.004), body mass index (r = 0.24, p = 0.022), RDW (r = 0.31, p = 0.03), oxygen desaturation index (ODI) (r = 0.22, p = 0.02), and negatively correlated with the hemoglobin concentration (r = - 0.28, p = 0.04) and minimum hemoglobin oxygen saturation (SpO2) (r = - 0.25, p = 0.02). Receiver operator curve (ROC) analysis showed that the optimal serum IMA, CRP, RDW, and NLR values were not different for predicting OSAS diagnosis (areas under the curves (AUC) = 0.62, 0.59, 0.60, and 0.43, respectively). However, the serum IMA level was superior in reflecting OSAS severity (AUC = 0.78) compared to CRP, RDW, and NLR values (AUC = 0.61, 0.53, and 0.51, respectively) (all p < 0.001). Conclusion Like other markers of inflammation, blood IMA levels were significantly elevated in patients with OSA. However, blood IMA level was a better predictor of disease severity than the other markers.Öğe DR-70, A promising biomarker for the detection of lung cancer>(European Respiratory Society Journals Ltd, 2021) Özgül, Güler; Koç, Aysu Sinem; Turan, Demet; Küçük, Suat Hayri; Özsoy, Şule; Baydili, Kürşad Nuri; Güler, Eray Metin; Özgül, Mehmet Akif; Eğri Kansu, Zeynep; Seyhan, Ekrem CengizIntroduction: Lung cancer is characterized by an aggressive phenotype with a high mortality rate, early metastasis, and proliferation rate. Treatment options and prognosis differ significantly at each stage. Various noninvasive imaging studies and invasive tests are available. However, the diagnosis of the disease is in the late stage. Therefore, it is essential to find biomarkers for the early detection of lung cancer. Material and Methods: Between 2018 and 2020, 73 lung cancer patients and 71 healthy volunteers with the same demographic characteristics were included in our study. DR-70 level was measured by a photometric method in serum samples taken from all volunteers. Results: A total of 144 volunteers (110 male, 34 female) were included in the study. DR-70 levels in the lung cancer group (2.53±2.64 µg/mL) were found to be statistically significantly higher than the healthy control group (0.56±1.23 µg/mL). Clinical sensitivity and specificity of DR-70 for lung cancer were found to be 87.67% and 88.73%. Conclusion: In patients with lung cancer, the high sensitivity and specificity DR-70 can be a biomarker for rapid diagnosis from the blood. Compared with other tumor biomarkers, DR-70 seems to have a better sensitivity and specificity in the diagnosis of lung cancer.Öğe DR-70: A promising biomarker for the detection of lung cancer(Verduci Publisher, 2021) Özgül, Güler; Koç, Aysu Sinem; Turan, Demet; Küçük, Suat Hayri; Özsoy, Şule; Baydili, Kürşad Nuri; Güler, Eray Metin; Özgül, Mehmet Akif; Eğri Kansu, Zeynep; Seyhan, Ekrem CengizObjective: Lung cancer (LC) is characterized by an aggressive phenotype with a high mortality rate, early metastasis, and proliferation rate. Treatment options and prognosis differ significantly at each stage. Despite the availability of multiple imaging studies and invasive procedures, the disorder is diagnosed at an advanced stage. Therefore, it is essential to find biomarkers for the early detection of LC. Patients and Methods: Between 2018 and 2020, 73 LC and 71 control with the same demographic characteristics were included in our study. DR-70 level was measured by a photometric method in serum samples taken from all subjects. Results: A total of 144 subjects (110 male, 34 female) was included in the study. DR-70 levels in the LC group (2.53 +/- 2.64 mu g/mL) were found to be statistically significantly higher than the control group (0.56 +/- 1.23 mu g/mL). Clinical sensitivity and specificity of DR-70 for LC were found to be 87.67% and 88.73%. Conclusions: The high sensitivity and specificity of DR-70 can be used as a biomarker for rapid diagnosis in patients with LC. Compared with other tumor biomarkers, DR-70 seems to have a better sensitivity and specificity in the diagnosis of LC.Öğe Endobronchial management of an endobronchial hamartoma(Türkiye Klinikleri, 2019) Seyhan, Ekrem Cengiz; Günlüoğlu, Mehmet Zeki; Düger, Mustafa; Özgül, Mehmet Akif; Çalış, Elif; Özöver, İremEndobronchial hamartoma (EH) is a rare benign tumor of the bronchial tree. This tumor can obstruct the bronchus or cause bleeding. The treatment method is chosen according to location and extent of the tumor. Endobronchial hamartoma can be resected via bronchoscopic approach; surgical therapy, is alternative only for cases where the tumor cannot be resected completely through endoscopy, or if irreversible pulmonary changes secondary to obstruction of the bronchus occurred. We herein describe a 52-year-old female presented with progressive dyspnea and treated with diagnosis of asthma. In this patient, EH which is located in the left main lobe bronchus was found in radiologic assement. Bronchoscopy revealed a broad-based mass obstructing the bronchus. The tumor was resected after coagulation of the tumor with argon plasma coagulation, by the rigid bronchoscope. Pathologic diagnosis was reported as EH. This report highlights the success of rigid bronchoscopic approach in the management of EH.Öğe Endotracheal ectopic parathyroid adenoma mimicking asthma(W.B. Saunders Ltd, 2014) Özgül, Mehmet Akif; Seyhan, Ekrem Cengiz; Özgül, Güler; Çetinkaya, Erdog?n; Büyükkale, Songül; Ünver, Nurcan; Çakır, Tansel; Sayar, AdnanPrimary benign tumors of the trachea are uncommon. These tumors may cause tracheal occlusion and lead to a misdiagnosis of asthma. Ectopic parathyroid adenoma (EPA) can be seen anywhere between the mandibular angle and the mediastinum. The distal part of the trachea is a rare location for EPA, and EPA obstructing the endotracheal lumen has not been reported in the literature. We herein describe a 52-year-old female with a several-year history of asthma treatment who presented with progressive dyspnea. Computed tomography revealed a mass that was obstructing the tracheal lumen. Total mass excision was performed via endobronchial treatment, and pathologic examination revealed EPA.Öğe Evaluation of pre and post-treatment positron emission tomogtaphy findings in small cell lung cancer(Wiley-Blackwell, 2014) Özgül, Güler; Toru, Ümran; Özgül, Mehmet Akif; Acat, Murat; Seyhan, Ekrem Cengiz; Annakkaya, Ali Nihat; Özkan, Sibel Ayşıl; Çetinkaya, Erdoğan[Abstract Not Available]Öğe Immunoglobulin G4-related lung disease presenting with a mediastinal mass(Turkiye Klinikleri Publisher, 2022) Oğuztürk, Gülçehre; Günlüoğlu, Mehmet Zeki; Seyhan, Ekrem CengizImmunoglobulin G4-related disease (IgG4-RD) is a recently identified systemic disease characterized by increased IgG4 level in serum and plasma cell infiltration resulting in “storiform fibrosis”. Although lung involvement is rare, clinical presentation is highly variable, including mediastinal lymphadenopathy, interstitial pneumonia, and pleural effusion. Glucocorticoid therapy is accepted as the mainstay treatment in IgG4-RD. Here, we present an IgG4-related lung disease (IgG4-RLD) case who was admitted to the hospital with chest pain; found out to have a mediastinal mass. IgG4-RLD was diagnosed based on histopathological features and a high blood IgG4 level. The patient’s steroid therapy was effective and there were no steroid-related side effects.Öğe Ischemia modified albumin in patients with obstructive sleep apnea syndrome(European Respiratory Society Journals Ltd, 2018) Seyhan, Ekrem Cengiz; Düger, Mustafa; Bolatkale, Mustafa; Eğri Kansu, Zeynep; Aynacı, Engin[Abstract Not Available]Öğe Mean platelet volume as an inflammation marker in active pulmonary tuberculosis(BioMed Central Ltd., 2014) Günlüoğlu, Gülşah; Ertan Yazar, Esra; Şimşek Veske, Nurdan; Seyhan, Ekrem Cengiz; Altın, SedatBackground: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined. Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated. Results: The MPV was 7.74 ± 1.33/µL in the PTB group and 8.20 ± 1.13/µL in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease. Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable.Öğe Predictive value of the tuberculin skin test and QuantiFERON-tuberculosis Gold In-Tube test for development of active tuberculosis in hemodialysis patients(Medknow Publications, 2016) Seyhan, Ekrem Cengiz; Günlüoğlu, Gülşah; Günlüoğlu, Mehmet Zeki; Tural, Seda; Sökücü, SinemBackground: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis infection (LTBI) compared with the general population. QuantiFERON-TB Gold (QFT-G) for LTBI detection is more promising than tuberculin skin test (TST) in HD patients. AIM: In our study, we evaluated the value of the TST and QFT-G In-Tube (QFG-IT) test in the development of active tuberculosis (TB), in the HD patients, and in healthy controls. Methods: The study enrolled 95 HD patients and ninety age-matched, healthy controls. The TST and QFG-IT were performed. All the subjects were followed up 5 years for active TB disease. Results: Compared to the healthy controls, a high prevalence of LTBI was found in the HD patients by QFG-IT (41% vs. 25%). However, no significant difference was detected by TST (32% vs. 31%). Four HD patients and one healthy control progressed to active TB disease within the 5-year follow-up. For active TB discovered subjects, QFG-IT was positive in all, but TST was positive in two (one patient and one healthy control). In HD patients; sensitivity, specificity, positive and negative predictive values of QFG-IT, and TST for active TB was 100% and 25%, 62% and 67%, 10%, and 3%, and 100% and 95%, respectively. Receiver operating curve analysis revealed that the results are significantly different (P = 0.04). Conclusion: QFG-IT test is a more useful diagnostic method than TST for detecting those who will progress to active TB in HD patients.Öğe Primary pulmonary synovial sarcoma: A very rare presentation(Hindawi Publishing Corporation, 2014) Seyhan, Ekrem Cengiz; Sokucu, Sinem Nedime; Günlüoğlu, Gülşah; Şimşek Veske, Nurdan; Altın, SedatSynovial sarcoma (SS) is a rare tumor originating from mesenchymal tissue and accounting for approximately 5–10% of all soft tissue sarcomas. A rare case of primary pulmonary SS in an asymptomatic 18-year-old man admitted to our hospital for investigation of a 6 × 6.5 cm, oval-shaped, well-delineated pleural based peripheral mass in the left lower lobe in his thorax CT is presented. Left lower lobectomy was done. Immunohistochemically, tumor cells were positive for cytokeratin, epithelial membrane antigen (EMA), and vimentin so that the histopathological diagnosis was compatible with biphasic spindle cell type SS in the lung.Öğe Pulmonary artery aneurysm ruptured into bronchus in a patient with Behçet's disease(Elsevier Doyma, 2017) Seyhan, Ekrem Cengiz; Günlüoğlu, Mehmet Zeki; Cengiz, ErolA 54-year-old man diagnosed with Behc ? et’s Disease (BD) 5 yearspreviously at another hospital was admitted to our center withmassive hemoptysis. The chest X-ray showed bilobular, smoothedged opacity localized in the left hilar and paracardiac regionthat not conceal heart contours (Fig. 1a, arrow).Öğe Red blood cell distribution width in patients with chronic obstructive pulmonary disease and healthy subjects(Elsevier Doyma Sl., 2017) Özgül, Güler; Seyhan, Ekrem Cengiz; Özgül, Mehmet Akif; Günlüoğlu, Mehmet ZekiBackground Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease (CVD). Red blood cell distribution width (RDW) is accepted as a powerful predictor of outcomes in patients with CVD. Aims To study RDW in patients with COPD, and to compare the value of this measurement with clinical, echocardiographic, nutritional and laboratory status. Secondly, we aimed to determine the effect of smoking on RDW values in healthy subjects. Methods One hundred and seventy-five patients with stable COPD and 210 healthy controls were enrolled in the study. Demographic, clinical, nutritional status, echocardiographic, and laboratory characteristics, RDW values were recorded and compared. Results RDW values were higher in the COPD group than in controls (15±2.3% vs 13.8±2.5%, p<0.001). In COPD patients, RDW levels positively correlated with CRP levels (r=0.27, p<.001), albumin levels (r=0.23, P=.04), right ventricular dysfunction (RVD) (r=0.24, P=.001), pulmonary hypertension (PAH) (r=0.1, P=.02), and presence of CVD (r=0.24, P=.02). In multivariable logistic regression suggested that presence of CVD (4.3; 95% CI: 1.3–11; P=.01), and presence of RVD (3.1; 95% CI: 1.7–8.3; P=.02) were independently related to elevated RDW levels in COPD patients. In the healthy population, correlations analysis showed only a significant correlation between RDW and cigarette smoking years (r=0.57, p<.001). Conclusion RDW is independently associated with CVD and RVD in patients with COPD. In the healthy population, RDW is also associated with smoking status.Öğe The effect of pet/ct-derived parameters on the prediction of survival in lung cancer patients(2024) Şimşek Veske, Nurdan; Ceran, İbrahim Fatih; Günlüoğlu, Gülşah; Günlüoğlu, Mehmet Zeki; Seyhan, Ekrem Cengiz; Bolat, Erkut; Sökücü, Sinem Nedime; Altın, SedatBackground: The ability to predict the survival of patients with non-small cell lung cancer (NSCLC) can provide a basis for individualized treatment and follow-up. Determination of positron emission tomography/computed tomography (PET/CT) parameters, i.e., maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), may improve predictions of survival for NSCLC patients. Objectives: To determine the relationship between the PET/CT-derived parameters SUVmax, SUVmean, MTV, and TLG and survival in NSCLC patients. Patients and Methods: Patients with NSCLC diagnosed at our clinic between January 2019 and October 2020 were evaluated retrospectively using data obtained from the electronic database. The study population consisted of 132 patients over 18 years of age who had a PET/CT scan before receiving any treatment for NSCLC. During their initial PET/CT evaluation, SUVmax, SUVmean, MTV, and TLG were calculated. Correlations between the variables were analyzed using Spearman’s correlation test, and the associations of the variables with patient survival were determined using the Cox proportional hazards regression model. Results: The overall 2-year survival rate of the patients was 36.6%. In the univariate analysis, MTV and TLG, but not SUVmax or SUVmean, were significantly associated with survival (P = 0.8, P = 0.003, and P = 0.045, respectively). In the multivariate analysis, MTV was related to a higher risk of death in patients with adenocarcinoma, lymph node involvement, or distant metastasis. By contrast, TLG was associated with a lower risk of death in patients with adenocarcinoma (ACA) or distant metastasis. Conclusion: Among the parameters obtained in PET/CT studies, SUVmax and SUVmean were not related to the survival of patients with NSCLC. However, MTV was associated with a higher risk of death, while TLG was associated with a lower risk of death in patients with adenocarcinoma or distant metastasis. Further studies with larger samples are needed to validate these results.Öğe The maximum standardized FDG uptake on PET-CT in patients with non-small cell lung cancer(Biomed Central Ltd, 2013) Özgül, Mehmet Akif; Kırkıl, Gamze; Seyhan, Ekrem Cengiz; Çetinkaya, Erdoğan; Özgül, Güler; Yüksel, MahmutBackground: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomography integrated positron emission tomography and tumor size, lymph node metastasis, and distant metastasis in patients with NSCLC. Methods: The records of 151 NSCLC patients (139 male, 12 female; mean age 59.60 years) were evaluated retrospectively. Results: Forty-one cases were adenocarcinomas; 45 squamous cell carcinomas; and 65 unspecified NSCLC. When the cases were categorized according to tumor size (group 1, <= 3 cm; group 2, > 3 and >= 5 cm; group 3, > 5 cm), the maximum standardized uptake value (SUVmax) was significantly lower in groups 1 and 2 compared with group 3 (p = 0.006 for each). Considering all cases, tumor SUVmax was not correlated with age, gender, or histopathological type. Lymph node metastases were pathologically proven in 24 cases: 24% of these were adenocarcinomas, 6% squamous cell carcinomas, and 16% unspecified NSCLC. Neither lymph node involvement nor distant metastases were correlated with tumor SUVmax, although lymph node size was positively correlated with lymph node SUVmax (r = 0.775; p < 0.001). Conclusions: SUVmax was significantly associated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases.
