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    Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
    (Wiley, 2021) Özkur, Ezgi; Karadağ, Ayşe Serap; Üstüner, P.; Aksoy, Bülent; Esme, Pelin; Çalışkan, E.; Akoğlu, Gülşen; Kalkan, Gülhan; Demirseren, Duriye Deniz; Polat, Mualla; Özden, Müge Güler; Kılınç, Fadime; Yalçınkaya İyidal, Ayşegül; Kıvanç Altunay, İlknur; Türkmen, Meltem; Uğurer, Ece; Baysak, Sevim; Fettahlıoğlu Karaman, Bilge; Mammadli, Kifayat; Baykal Selçuk, Leyla; Türkoğlu, Zülal; Atçı, Tolgahan; Didar Balcı, Didem; Özsoy Adışen, Esra; Temel, Berkay; Aktan, Serhat; Gelincik Kaçar, Nida; Gündüz, Kamer; Türel Ermertcan, Aylin; Özdemir, Mustafa; Ünal Çakıter, Alkım; Çölgeçen, Emine; Uçmak, Derya; Kelekçi, Handan Kıymet; Ataseven, Arzu; Durmaz, Koray; Kaya Özden, Hatice; Engin, Berat; Özbek Yazıcı, Sercan; Alpsoy, Erkan
    Background Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.
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    Habits of using social media and the internet in psoriasis patients
    (Mattioli 1885, 2022) Kayıran, Melek Aslan; Karadağ, Ayşe Serap; Oğuz Topal, İlteriş; Özsoy Adışen, Esra; Kılıç, Sevilay Oğuz; Keskin, Nuray; Polat, Asude Kara; Cemil, Bengü Çevirgen; Polat, Mualla; Yılmaz, Oğuz; Ayvaz, Hilal; Topalo?lu Demir, Filiz; Sarıkaya Solak, Sezgi; Uçmak, Derya; Gürel, Mehmet Salih Alih; Aytekin, Sema; Polat Ekinci, Algün; Bölük, Kübra Nursel; Şendur, Neslihan; Akbulut, Tuğba Özkök; Öztürk, Günseli; Acar, Ayda; Alpsoy, Erkan
    Introduction: Psoriasis significantly affects the patients quality of life, which often leads patients to seek online information about this disease. Objectives: To explore the habits of patients with psoriasis related to their use of social media (SM) and the internet to obtain information about their disease. Methods: 1,520 patients completed the survey and the Dermatology Life Quality Index (DLQI) questionnaire. The Psoriasis Area Severity Index scores (PASI) and clinical data of the patients were recorded by their physicians. Results: Of the 1,114 patients that reported using SM and internet, 48.38% regularly and 31.14% sometimes resorted to obtain information about psoriasis. The use of SM and internet for psoriasis was statistically significantly higher among young people (P = 0.000), those with university or higher education (P = 0.009), higher DLQI (P = 0.000) and PASI (P = 0.011) scores, facial (P = 0.050), scalp (P = 0.032), hand (P = 0.048), genital (P = 0.001) and inverse (P = 0.000) involvement, and arthralgia/arthritis (P = 0.006). The participants mostly used the Google (86%) and Facebook (41%). More than half of the participants (62.8%) expected dermatologists to inform society that psoriasis is not contagious. Conclusions: Internet and SM being widely available and offering substantial information to be easily accessed make it very attractive for patients to use these platforms to investigate diseases, including psoriasis. If what is presented on SM conflicts with what the physician says, patients mostly trust the latter, but at the same time, they tend not to share the results of their online inquiries with their physicians.
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    Patient use of complementary and alternative medicine for psoriasis vulgaris and factors believed to trigger the disease: A multicenter cross-sectional study with 1621 patients
    (Mattioli 1885, 2022) Aslan Kayıran, Melek; Karadağ, Ayşe Serap; Topal, İlteriş Oğuz; Emre, Selma; Adışen, Esra; Kılıç, Sevilay; Keskin, Nuray; Kara Polat, Asude; Çevirgen Cemil, Bengü; Polat, Mualla; Yılmaz, Oğuz; Ayvaz, Hilal; Topaloğlu Demir, Filiz; Sarıkaya Solak, Sezgi; Uçmak, Derya; Aytekin, Sema; Gürel, Mehmet Salih; Polat Ekinci, Algün; Bölük, Kübra Nursel; Şendur, Neslihan; Özkök Akbulut, Tuğba; Öztürk, Günseli; Erbaş, Ayda; Alpsoy, Erkan
    Introduction: Due to the chronic recurrent nature of psoriasis vulgaris (PV) and lack of definitive treatment for the disease, patients often resort to alternative treatments. Physicians seem to have low awareness of this issue. Objectives: To elicit the perceptions of 1,621 PV patients on complementary and alternative medicine (CAM) and examine factors reported to worsen PV. Methods: The patients sociodemographic characteristics, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), disease duration, and severity were recorded, and the patients CAM use was questioned in detail. The patients were also asked about factors that worsened PV and their experiences with a gluten-free diet. Results: Of the patients, 56.51% had used CAM. The mean age, illness duration, PASI scores and DLQI of those using CAM were significantly higher. CAM use was significantly higher in those with facial, genital involvement, and arthralgia/arthritis. The patients mostly referred to CAM when PV became severe (46.4%). Of the CAM users, 45.52% used herbal topicals. The physicians of 67.03% did not inquire whether they used CAM. Of the participants, 37.73% considered that stress worsened their disease. Gluten-free diet did not affect PV symptoms in 52.22%. Conclusions: Patients CAM use is often overlooked by dermatologists. Our results showed that more than half the patients used CAM and did not share this information with their physicians. Therefore, the awareness of physicians should be increased and patients should be asked about the use of CAM and directed to the appropriate medical treatment options by physicians.