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  • Küçük Resim
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    Efficacy and safety profile of COVID-19 vaccine in cancer patients: A prospective, multicenter cohort study
    (Future Medicine Ltd, 2022) Yasin, Ayşe İrem; Göktaş Aydın, Sabin; Sümbül, Bilge; Koral, Lokman; Şimsek, Melih; Geredeli, Çağlayan; Öztürk, Akın; Perkin, Perihan; Demirtaş, Derya; Erdemoğlu, Engin; Hacıbekiroğlu, İlhan; Çakır, Emre; Tanrıkulu, Eda; Çoban, Ezgi; Özçelik, Melike; Çelik, Sinemis; Teker, Fatih; Aksoy, Asude; Fırat, Sedat T.; Tekin, Ömer; Kalkan, Ziya; Türken, Orhan; Öven, Bala Başak; Dane, Faysal; Bilici, Ahmet; Işıkdoğan, Abdurrahman; Şeker, Mesut; Türk, Hacı Mehmet; Gümüş, Mahmut
    Aim: To compare the seropositivity rate of cancer patients with non-cancer controls after inactive SARS-CoV-2 vaccination (CoronaVac) and evaluate the factors affecting seropositivity. Method: Spike IgG antibodies against SARS-CoV-2 were measured in blood samples of 776 cancer patients and 715 non-cancer volunteers. An IgG level >= 50 AU/ml is accepted as seropositive. Results: The seropositivity rate was 85.2% in the patient group and 97.5% in the control group. The seropositivity rate and antibody levels were significantly lower in the patient group (p < 0.001). Age and chemotherapy were associated with lower seropositivity in cancer patients (p < 0.001). Conclusion: This study highlighted the efficacy and safety of the inactivated vaccine in cancer patients. Clinical Trials Registration: ClinicalTrials.gov) Plain language summary Cancer patients are at high risk for infection with SARS-CoV-2 and of developing the associated disease, COVID-19, which therefore puts them in the priority group for vaccination. This study evaluated the efficacy and safety of CoronaVac, an inactivated virus vaccine, in cancer patients. The immune response rate, defined as seropositivity, was 85.2% in the cancer patient group and 97.5% in the control group. The levels of antibodies, which are blood markers of immune response to the vaccine, were also significantly lower in the patient group, especially in those older than 60 years and receiving chemotherapy. These results highlight the importance of determining the effective vaccine type and dose in cancer patients to protect them from COVID-19 without disrupting their cancer treatment.
  • Küçük Resim Yok
    Öğe
    Efficacy of adjuvant capecitabine in residual triple negative breast cancer: a multicenter observational Turkish Oncology Group (TOG) study
    (2024) Şenocak Taşçı, Elif; Kutlu, Yasin; Ölmez, Ömer Fatih; Mutlu, Arda Ulaş; Gündoğdu, Yasemin; Seyyar, Mustafa; Şahin, Elif; Çabuk, Devrim; Majidova, Nargiz; Uğurlu, İrem; Demirci, Ayşe; Aydın, Dinçer; Çavdar, Eyyüp; Bayram, Selami; Yıldırım, Nilgün; Karataş, Fatih; Karakurt Eryılmaz, Melek; Çağlayan, Dilek; Menekşe, Serkan; Kut, Engin; Arak, Hacı; Keser, Murat; Sunar, Veli; Perkin, Perihan; Şakalar, Teoman; Oyan, Başak; Sönmez, Özlem; Özer, Leyla; Yıldız, İbrahim
    Background: Triple negative breast cancer (TNBC) is characterized by high rates of recurrence, especially in patients with residual disease after neoadjuvant chemotherapy (NAC). Capecitabine is being used as standard adjuvant treatment in residual TNBC. We aimed to investigate the real-life data regarding the efficacy of capecitabine in residual TNBC. Design and methods: In this retrospective multicenter study, TNBC patients with residual disease were evaluated. Patients, who received standard anthracycline and taxane-based NAC and adjuvant capecitabine were eligible. Overall survival (OS), disease free survival (DFS) and toxicity were analyzed. Results: 170 TNBC patients with residual disease were included. Of these, 62.9% were premenopausal. At the time of analysis, the recurrence rate was 30% and death rate was 18%. The 3-year DFS and OS were 66% and 74%, respectively. In patients treated with adjuvant capecitabine, residual node positive disease stood out as an independent predictor of DFS (p = 0.024) and OS (p = 0.032). Undergoing mastectomy and the presence of T2 residual tumor was independent predictors of DFS (p = 0.016) and OS (p = 0.006), respectively. Conclusion: The efficacy of capecitabine was found lower compared to previous studies. Selected patients may have further benefit from addition of capecitabine. The toxicity associated with capecitabine was found lower than anticipated.