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Öğe An investigation of anthropometric measurements of early adolescents and determination of BMI-for-age-based neck circumference and BMI-for-age-based mid-upper-arm circumference cut-off points(Elsevier, 2022) Mercan, Yeliz; Çakmak Kafadar, Gökçe; Arıkan, Sünbül Hülya; Pancar, NüketBackground & aims: This study aimed to examine the anthropometric measurements of adolescents between the ages of 10 and 13, and to determine the BMI-for-age-based neck circumference (NC) and BMI-for-age-based mid-upper-arm circumference (MUAC) cut-off points for this age group. Methods: This methodological study was conducted with 626 students of early adolescent age in Kirklareli in Turkey. The cut-off values of BMI-for-age-based NC and MUAC were determined by ROC analysis from severe thinness to obesity. The most suitable AUC value was evaluated according to LR(+) and LR(-) and Sensitivity and Specificity were shown. Results: The frequency of severe thinness, thinness, overweight, obese among adolescents was 8.0%, 8.9%, 11.7%, and 16.3%, respectively. WHpR of 14.4% of the adolescents was >= 0.90 in boys and >= 0.85 in girls. According to WHtR, 23.8% had a value of <0.40 and, 17.8% had a value of >= 0.50. BMI-for-age-based NC cut-off points were severe thinness, thinness, overweight, obesity 25.50, 26.50, 29.50, 30.50 cm in girls, respectively; 26.50, 27.50, 30.50, 31.50 cm in boys, respectively. BMI-for-age-based MUAC cut-off points were severe thinness, thinness, overweight, obesity 19.50, 20.50, 24.50, 25.50 cm in girls, respectively; 19.50, 20.50, 25.50, 26.50 cm in boys, respectively. Conclusions: Double burden of malnutrition was identified in early adolescents. The cutoff points for NC and MUAC found in this study showed good specificity to identify double burden of malnutrition in early adolescents and can be used as a reference in especially in cases of insufficient resources or isolated environments.Öğe Effect of boron-based gel on postpartum episiotomy wound healing in primiparous pregnant women(Bayrakol Medical Publisher, 2023) Kanza Gül, Derya; Mercan, YelizAim: The present study aimed to determine the effects of boron-based gel on episiotomy wound healing and episiotomy pain in primiparous women. Material and Methods: This case-time control design, which is one of the hybrid designs included 450 primiparous women who had a normal delivery with episiotomy at Private Nisa Hospital between January 2019 and March 2020. The participants were grouped as 150 women who used the Boron-Based Gel on the postpartum episiotomy site (cases-1), 150 women who used Beta Chlorhexidine Gel (cases-2), and 150 women who refused treatment or did not use any topical gel (controls). Wound healing status was evaluated on days 2, 5-7, and 10-14 after birth along with Redness, Edema, Ecchymosis, Discharge with Approximation (REEDA) Scale, and the pain levels felt in the episiotomy area were evaluated using the Visual Analog Scale (VAS). Results: No statistically significant differences were detected between the three groups in terms of age and other variables (p>0.05). The mean scores of VAS and REEDA on days 2, 5-7, and 10-14 after birth were significantly different in the Boron-Based Gel Group compared to Chlorhexidine Gel and control group (p<0.001). Discussion: It was found that the use of Boron-Based Gel increased episiotomy wound healing and reduced pain at significant levels.Öğe Effect of oral use of various edible oils on wound healing in rats: Randomized controlled experimental study(Istanbul Medipol University, 2022) Çakmak Kafadar, Gökçe; Büyükuslu, Nihal; Kolbaşı, Bircan; Keskin, İlknur; Mercan, YelizThere are various studies showing that oral supplements are shortening or facilitat-ing effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the 7 groups (control, Hypericum perforatum extracts in olive oil, olive, sesame, fish, black seed, sunflower), each has 8 Wistar Albino rats. In the experimental groups, 1.25 mL/kg oral oil was used for 10 days. Macroscopic images of the wound area were taken. Wound healing was evaluated by histological analysis. Collagen III, IL-6, TNF-? and TGF-ß1 density analyzes were performed on the tissue samples. According to macroscopic analysis, wound narrowing is higher in all groups on the 2nd and 4th days than the control group. Histopathological and immunohistochemical analyses of all experimental groups except sunflower oil group revealed better results than control group.Öğe Sıçanlarda oral yağ kullanımının yara iyileşmesi üzerine etkileri(İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022) Çakmak Kafadar, Gökçe; Büyükuslu, Nihal; Mercan, YelizYara iyileşme sürecinde birçok modern ve geleneksel tedavi yöntemi geliştirilmekle birlikte geleneksel tedaviler uygun maliyetli ve erişimi kolaydır. Bu çalışmada, deneysel olarak yara oluşturulan sıçanlarda tüketilebilir çeşitli yağların oral kullanımının yara iyileşmesi üzerindeki makroskopik, histolojik ve immünohistolojik etkilerinin incelenmesi amaçlanmıştır. Çalışma 7 gruptan oluşmaktadır: Kontrol, Hypericum perforatum (Kantaron) zeytinyağı ekstraktı (HPEO), zeytinyağı, susam yağı, balık yağı, çörek otu yağı ve ayçiçek yağı. Her gruba 8 adet Wistar Albino sıçan bulunmaktadır. Deney gruplarında 1,25 mL/kg/gün yağ 10 gün boyunca gavaj yolu ile verilmiştir. Bu süreçte 2 günde bir yara alanlarının makroskopik fotoğraflanması yapılmıştır. Yara iyileşme skorlaması histolojik analiz sonrası yapılmıştır. Yara dokusu örneklerinde Kolojen III, IL-6, TNF-? ve TGF ß1 yoğunluk analizleri incelenmiştir. Makroskopik analizlere göre, yara kapanması 2. ve 4. günlerde tüm deney gruplarında kontrolden daha fazladır. Epidermal dermal rejenerasyon skorlamasında en başarılı gruplar HPEO, zeytinyağı, susam yağı ve çörek otu yağı gruplarıdır skorları sırasıyla 3,3, 3,4 3,4, 3,6 şeklindedir. Granülasyon doku kalınlığı skorlamasında en başarılı gruplar HPEO, zeytinyağı ve susam yağı gruplarıdır skorları sırasıyla 3,3, 3,1, 3,6 şeklindedir. Anjiyogenesiz skorlamasında en başarılı gruplar HPEO ve susam yağı gruplarıdır skorları sırasıyla 3,8, 3,6 şeklindedir. İmmünohistolojik analizler sonucunda tüm gruplar arasında en yüksek Kolajen III yoğunluğu gösteren grup HPEO (48,49±3,33); en düşük IL-6 yoğunluğu gösteren grup balık yağı (11,09±4,92); en yüksek TGF-ß1 yoğunluğu gösteren grup HPEO (47,52±2,45) ve en düşük TNF-? yoğunluğu gösteren grup balık yağıdır (35,55±4,05). Bu çalışma ve literatür incelemesi sonucunda HPEO grubunun yara iyileşmesinde umut vaadeden sonuçları olduğu görülmektedir. Ancak analiz sonuçlarına göre zeytinyağı ve susam yağlarının da yara iyileşmesinde etkili olabileceğini görülmektedir.
