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    A proposal for improved t-staging of pancreatic ductal adenocarcinoma by using microscopic examination as the basis for determining the size and t-stage
    (Nature Publishing Group, 2020) Baştürk, Olca; Reid, Michelle; Balcı, Serdar; Erbarut Seven, İpek; Saka, Burcu; Pehlivanoğlu, Burçin; Memis, Bahar; Bağcı, Pelin; Adsay, Nazmi Volkan
    Background: Stage remains as the most helpful prognosticator in pancreatic ductal adenocarcinoma (PDAC). However, accurate grossmeasurement of PDAC tumor size, the main stage parameter, is a well-known challenge due to its notoriously ill-defined nature. It hasbeen well documented that there are often satellite microtumor foci beyond the grossly appreciated tumor (PMID: 26832882), which in factmay represent intraparenchymal metastases. This becomes a bigger challenge if the gross room personnel are not experienced enough forthe subtleties of PDAC.
  • Küçük Resim
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    A proposal for improved t-staging of pancreatic ductal adenocarcinoma by using microscopic examination as the basis for determining the size and t-stage
    (Nature Publishing Group, 2020) Baştürk, Olca; Reid, Michelle; Balcı, Serdar; Erbarut Seven, İpek; Saka, Burcu; Pehlivanoğlu, Burçin; Memis, Bahar; Bağcı, Pelin; Adsay, Nazmi Volkan
    Background: Stage remains as the most helpful prognosticator in pancreatic ductal adenocarcinoma (PDAC). However, accurate grossmeasurement of PDAC tumor size, the main stage parameter, is a well-known challenge due to its notoriously ill-defined nature. It hasbeen well documented that there are often satellite microtumor foci beyond the grossly appreciated tumor (PMID: 26832882), which in factmay represent intraparenchymal metastases. This becomes a bigger challenge if the gross room personnel are not experienced enough forthe subtleties of PDAC.
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    Non-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases
    (2020) Taşkın, Orhun; Bellolio, Enrique; Dursun, Nevra; Erbarut Seven, İpek; Roa, Juan C.; Araya, Juan C.; Villaseca, Miguel; Tapia, Oscar; Vance, Courtney; Saka, Burcu; Balcı, Serdar; Bağcı, Pelin; Losada, Hector; Sarmiento, Juan; Memis, Bahar; Pehlivanoğlu, Burçin; Baştürk, Olca; Reid, Michelle D.; Koshiol, Jill; Cheng, Jeanette; Kapran, Yersu; Adsay, Volkan
    There is no systematic histopathologic analysis of non-neoplastic polyps in the gallbladder. In this study, in addition to a computer search for cases designated as "polyp," a systematic review of 2533 consecutive routinely sampled archival and 203 totally submitted prospective cholecystectomies were analyzed for >2?mm polyps (cut-off was based on radiologic sensitivity). A total of 447 non-neoplastic polyps were identified. The frequency was 3% in archival cases and 5% in totally submitted cases. Only 21 (5%) were ?1?cm. The average age was 52 years, and the female to male ratio was 3.1. Two distinct categories were delineated: (1) injury-related polyps (n=273): (a) Fibro(myo)glandular polyps (n=214) were small (mean=0.4?cm), broad-based, often multiple (45%), almost always (98%) gallstone-associated, and were composed of a mixture of (myo)fibroblastic tissue/lobular glandular units with chronic cholecystitis. Dysplasia seen in 9% seemed to be secondary involvement. (b) Metaplastic pyloric glands forming polypoid collections (n=42). (c) Inflammatory-type polyps associated with acute/subacute injury (11 granulation tissue, 3 xanthogranulomatous, 3 lymphoid). (2) Cholesterol polyps (n=174) occurred in uninjured gallbladders, revealing a very thin stalk, edematous cores devoid of glands but with cholesterol-laden macrophages in 85%, and cholesterolosis in the uninvolved mucosa in 60%. Focal low-grade dysplasia was seen in 3%, always confined to the polyp, unaccompanied by carcinoma. In conclusion, non-neoplastic polyps are seen in 3% of cholecystectomies and are often small. Injury-related fibromyoglandular polyps are the most common. Cholesterol polyps have distinctive cauliflower architecture, often in a background of uninjured gallbladders with cholesterolosis and may lack the cholesterol-laden macrophages in the polyp itself. Although dysplastic changes can involve non-neoplastic polyps, they do not seem to be the cause of invasive carcinoma by themselves.