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  • Küçük Resim Yok
    Öğe
    Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease
    (Oxford University Press Inc., 2023) Babiloni, Claudio; Lopez, Susanna; Noce, Giuseppe; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; Salvatore, Marco; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Massa, Federico; Buttinelli, Carla; Giubilei, Franco; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; D'Antonio, Fabrizia; Bruno, Giuseppe; de Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Yerlikaya, Deniz; Taylor, John Paul; Schumacher, Julia; Mckeith, Ian; Bonanni, Laura; Pantano, Patrizia; Piervincenzi, Claudia; Petsas, Nikolaos; Frisoni, Giovanni B.; del Percio, Claudio; Carducci, Filippo
    Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.
  • Küçük Resim
    Öğe
    Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
    (2024) Babiloni, Claudio; Jakhar, Dharmendra; Tucci, Federico; Del Percio, Claudio; Lopez, Susanna; Soricelli, Andrea; Salvatore, Marco; Ferri, Raffaele; Catania, Valentina; Massa, Federico; Arnaldi, Dario; Famà, Francesco; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; Giubilei, Franco; Yıldırım, Ebru; Hanoğlu, Lütfü; Hünerli, Duygu; Frisoni, Giovanni B.; Noce, Giuseppe
    Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ? ?10% and ?10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups.