Yazar "Mammadov, Elkhan" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The predictive importance of body mass index on response to neoadjuvant chemotherapy in patients with breast cancer
    (Karger, 2023) Emirzeoğlu, Levent; Arıcı, Serdar; Şahin, Ahmet Bilgehan; Ocak, Birol; Ak, Naziye; Ay, Seval; Mammadov, Elkhan; Turna, Hande; Bilici, Ahmet
    Purpose: The aim of the study was to investigate the effects of body mass index (BMI) on the response to neoadjuvant chemotherapy (NACT) in Turkish patients with local and locally advanced breast cancer. Methods: The pathological responses for the breast and axilla were assessed according to the Miller-Payne grading (MPG) system. Tumors were grouped into molecular phenotypes and classified as response rates according to the MPG system after the completion of NACT. A 90% or greater reduction in tumor cellularity was considered a good response to treatment. Additionally, patients were grouped according to BMI into <25 (group A) and ?25 (group B). Results: In total, 647 Turkish women with breast cancer were included in the study. In the univariate analysis, age, menopause status, tumor diameter, stage, histological grade, Ki-67, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, and BMI were assessed to determine which of these factors were associated with a ?90% response rate. Stage, HER2 positivity, triple-negative breast cancer (TNBC; ER-negative, PR-negative, and HER2-negative breast cancer), grade, Ki-67 levels, and BMI were found to be the statistically significant factors for a ?90% response rate. In the multivariate analysis, grade III disease, HER2 positivity, and TNBC were found to be the factors associated with a high pathological response. Meanwhile, hormone receptor (HR) positivity and a higher BMI were associated with a decreased pathological response in patients receiving NACT for breast cancer. Conclusion: Our results show that a high BMI and HR positivity are associated with a poor response to NACT in Turkish patients with breast cancer. The findings presented in this study may guide novel studies to examine the NACT response in obese patients with and without insulin resistance.
  • Küçük Resim
    Öğe
    Triple-negative breast cancer presented with metastasis to the heart as first sign of recurrence
    (Wiley, 2021) Bayramgil, Ayberk; Bilici, Ahmet; Hamdard, Jamshid; Açıkgöz, Özgür; Şeker, Mehmet; Kılıçaslan, Fethi; Köksal, Cengiz; Büyükpınarbaşılı, Nur; Mammadov, Elkhan; Göktaş Aydın, Sabin; Ölmez, Ömer Fatih; Yıldız, Özcan
    A 34-year-old woman had a history of breast cancer and underwent a right-sided nipple-sparing mastectomy and axillary dissection in 2014. She was staged as pT2N2aM0, IIIA, and the histopathological type was TNBC, grade 3. Ki-67 index was 35%-40%. The patient received four cycles of adjuvant dose-dense doxorubicin and cyclophosphamide followed by four cycles of docetaxel. Radiotherapy to her chest wall and regional lymph node was performed with 60 Gy in 30 fractions as adjuvant therapy, and she was followed without any recurrence until February 2019.