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    Abnormalities of cortical sources of resting state alpha electroencephalographic rhythms are related to education attainment in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
    (NLM (Medline), 2021) Babiloni, Claudio C.; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Panzavolta, Andrea; Soricelli, Andrea; Nobili, Flavio Mariano; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hano?lu, Lütfü; Yener, Görsev G.; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Glovannl B.; del Percio, Claudio
    In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
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    Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases
    (Elsevier Inc., 2022) Babiloni, Claudio; Lorenzo, Ivan; Lizio, Roberta; Lopez, Susanna; Tucci, Federico; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Taylor, John Paul; Schumacher, Julia; McKeith, Ian; Frisoni, Giovanni B.; De Pandis, Maria Francesca; Bonanni, Laura; Percio, Claudio Del; Noce, Giuseppe
    Please modify the Abstract as follows:Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to the eyes-open condition may differ in patients with dementia due to Lewy Bodies (DLB) and Alzheimer's disease (ADD) as a functional probe of the dominant neural synchronization mechanisms regulating the vigilance in posterior visual systems.We used clinical, demographical, and rsEEG datasets in 28 older adults (Healthy), 42 DLB, and 48 ADD participants. The eLORETA freeware was used to estimate cortical rsEEG sources.Results showed a substantial (> -10%) reduction in the posterior alpha activities during the eyes-open condition in 24 Healthy, 26 ADD, and 22 DLB subjects. There were lower reductions in the posterior alpha activities in the ADD and DLB groups than in the Healthy group. That reduction in the occipital region was lower in the DLB than in the ADD group.These results suggest that DLB patients may suffer from a greater alteration in the neural synchronization mechanisms regulating vigilance in occipital cortical systems compared to ADD patients.
  • Küçük Resim Yok
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    Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
    (Oxford University Press Inc, 2022) Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B.; del Percio, Claudio
    In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.
  • Küçük Resim Yok
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    Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
    (IOS Press, 2021) Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; del Percio, Claudio
    Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8-13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8-12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with mild cognitive impairment due to Alzheimer's disease (ADMCI). Methods: Clinical and rsEEG datasets in 63 ADMCI and 60 Nold individuals (matched for demography, education, and gender) were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands, as well as fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Results: As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical effects in posterior regions. On the contrary, in relation to the younger ADMCI subgroups, the older one displayed a lesser reduction in those rhythms. Notably, the ADMCI subgroups pointed to similar cerebrospinal fluid AD diagnostic biomarkers, gray and white matter brain lesions revealed by neuroimaging, and clinical and neuropsychological scores. Conclusion: The present results suggest that age may represent a deranging factor for dominant rsEEG alpha rhythms in Nold seniors, while rsEEG alpha rhythms in ADMCI patients may be more affected by the disease variants related to earlier versus later onset of the AD.