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    Correction: The pleiotropic effects of TNF? in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)
    (Nature Publishing Group, 2019) Lee, Eunmi; Ouzounova, Maria D.; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John K.; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan
    Following publication of this article the authors noted that the Acknowledgments section had been omitted. This section should read as follows.
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    Dual function of HSP70 in cytoprotection of tumor cells and generation of immunosuppressive tumor microenvironment
    (American Association for Cancer Research, 2021) Korkaya, Hasan; Köksalar Alkan, Fulya; Ece Arslan, Z.; Altıntaş, Esra; Piranlıoğlu, Raziye; Lee, Eunmi; Wicha, Max S.
    [Abstract Not Available]
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    The pleiotropic effects of TNF alpha in breast cancer subtypes is regulated by TNFAIP3/A20 (vol 38, pg 469, 2018)
    (Nature Publishing Group, 2019) Lee, Eunmi; Ouzounova, Maria; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John Kenneth; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan
    Following publication of this article the authors noted that the Acknowledgments section had been omitted. This section should read as follows.
  • Küçük Resim
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    The pleiotropic effects of TNF? in breast cancer subtypes is regulated by TNFAIP3/A20
    (Nature Publishing Group, 2019) Lee, Eunmi; Ouzounova, Maria; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John Kenneth; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan
    TNF alpha is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNF alpha exerts its diverse effects on breast cancer subtypes remains elusive. Using in vitro assays and mouse xenografts, we show here that TNF alpha contributes to the aggressive properties of triple negative breast cancer (TNBC) cell lines via upregulation of TNFAIP3(A20). In a striking contrast, TNF alpha induces a potent cytotoxic cell death in luminal (ER+) breast cancer cell lines which fail to upregulate A20 expression. Overexpression of A20 not only protects luminal breast cancer cell lines from TNF alpha-induced cell death via inducing HSP70-mediated anti-apoptotic pathway but also promotes a robust EMT/CSC phenotype by activating the pStat3-mediated inflammatory signaling. Furthermore, A20 overexpression in luminal breast cancer cells induces aggressive metastatic properties in mouse xenografts via generating a permissive inflammatory microenvironment constituted by granulocytic-MDSCs. Collectively, our results reveal a mechanism by which A20 mediates pleiotropic effects of TNF alpha playing role in aggressive behaviors of TNBC subtype while its deficiency results in TNF alpha-induced apoptotic cell death in luminal breast cancer subtype.