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Öğe Comparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology(W.B. Saunders, 2024) Kuzucular, Elif; Özden, Ferhat; Müezzinoğlu, BaharBackground: Cervical cancer is a global public health problem with high mortality. Advances in screening programs for cervical cancer are considered key to eliminate cervical cancer. We aimed to examine the contribution of cell block analysis to the detection of epithelial cell abnormalities in cervical smear samples. Methods: A total of 559 patients with suspected cervical pathology were examined, and their samples were analyzed by both liquid-based cytology (LBC) and cell blocks. The biopsy results of 149 out of the 559 patients were obtained. Results: Of the 50 patients who were identified as HSIL by biopsy, only 12 were diagnosed as HSIL by the LBC method, 22 as LSIL, 12 as ASCUS, and 4 as ASC-H (p < 0.001). With the cell block analysis, results for these patients were: 20 HSIL, 17 LSIL, 7 NILM, 4 ‘unsatisfactory’, and 2 ASC cases (p < 0.001). LBC detected only 1 of the 10 patients with biopsy-diagnosed tumors, while 7 of these were defined as HSIL, 1 as ASCUS and 1 as AGC. The results of cell block analysis in patients with biopsy-diagnosed tumors were as follows: 7 HSIL, 1 tumor, 1 ASC and 1 LSIL. Conclusions: Cell block analysis might be superior to LBC in terms of diagnostic accuracy in cervical pathologies, particularly in the detection of HSIL. However, both methods were similarly poor in diagnosing tumors. Cell blocks may improve diagnostic accuracy and can be a complementary method to LBC, while having the advantage of revealing histological architecture.Öğe Evaluation of mismatch repair status in colorectal carcinoma(Springer, 2022) Yılmaz Erözbek, Sıla; Bayramoğlu, Zeynep; Kuzucular, Elif; Özden, Ferhat[Abstract Not Available]Öğe Histopathological evaluation of gastrointestinal stromal tumours(Springer, 2022) Bayramoğlu, Zeynep; Yılmaz Erözbek, Sıla; Kuzucular, Elif; Özden, Ferhat[Abstract Not Available]Öğe Leukocytoclastic vasculitis after COVID-19 vaccination(Wiley, 2022) Altun, Ece; Kuzucular, ElifLeukocytoclastic vasculitis (LCV) is the vasculitis of small vessels. In this report, we describe a 38-year-old male patient who presented to our outpatient clinic with a 1-week history of rash on his lower extremities that had started 4 days after receiving the Pfizer-BioNTech SARS-CoV-2 vaccine. A diagnosis of LCV was made based on clinical and histopathological findings. The patient was treated with antihistamines and prednisolone, after which improvement was observed in the lesions. With this paper, we aim to raise awareness concerning the possibility of LCV development after COVID-19 vaccination.Öğe Mismatch repair status and PDL-1 expression in gastric carcinoma(Springer, 2022) Bayramoğlu, Zeynep; Yılmaz Erözbek, Sıla; Kuzucular, Elif; Özden, Ferhat[Abstract Not Available]
